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Estrogen signalling and Alzheimer's disease: Decoding molecular mechanisms for therapeutic breakthrough.

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Title: Estrogen signalling and Alzheimer's disease: Decoding molecular mechanisms for therapeutic breakthrough.
Authors: Rishabh (AUTHOR), Rohilla, Manni (AUTHOR), Bansal, Seema (AUTHOR), Bansal, Nitin (AUTHOR), Chauhan, Samrat (AUTHOR), Sharma, Sheenam (AUTHOR), Goyal, Navjyoti (AUTHOR), Gupta, Sumeet (AUTHOR)
Source: European Journal of Neuroscience. Jul2024, Vol. 60 Issue 1, p3466-3490. 25p.
Subjects: Estrogen receptors, Alzheimer's disease, Hormone therapy, Insulin-like growth factor receptors, Brain-derived neurotrophic factor, Somatomedin C, Calcium channels
Abstract: In females, Alzheimer's disease (AD) incidences increases as compared to males due to estrogen deficiency after menopause. Estrogen therapy is the mainstay therapy for menopause and associated complications. Estrogen, a hormone with multifaceted physiological functions, has been implicated in AD pathophysiology. Estrogen plays a crucial role in amyloid precursor protein (APP) processing and overall neuronal health by regulating various factors such as brain‐derived neurotrophic factor (BDNF), intracellular calcium signalling, death domain‐associated protein (Daxx) translocation, glutamatergic excitotoxicity, Voltage‐Dependent Anion Channel, Insulin‐Like Growth Factor 1 Receptor, estrogen‐metabolising enzymes and apolipoprotein E (ApoE) protein polymorphisms. All these factors impact the physiology of postmenopausal women. Estrogen replacement therapies play an important treatment strategy to prevent AD after menopause. However, use of these therapies may lead to increased risks of breast cancer, venous thromboembolism and cardiovascular disease. Various therapeutic approaches have been used to mitigate the effects of estrogen on AD. These include hormone replacement therapy, Selective Estrogen Receptor Modulators (SERMs), Estrogen Receptor Beta (ERβ)‐Selective Agonists, Transdermal Estrogen Delivery, Localised Estrogen Delivery, Combination Therapies, Estrogen Metabolism Modulation and Alternative Estrogenic Compounds like genistein from soy, a notable phytoestrogen from plant sources. However, mechanism via which these approaches modulate AD in postmenopausal women has not been explained earlier thoroughly. Present review will enlighten all the molecular mechanisms of estrogen and estrogen replacement therapies in AD. Along‐with this, the association between estrogen, estrogen‐metabolising enzymes and ApoE protein polymorphisms will also be discussed in postmenopausal AD. [ABSTRACT FROM AUTHOR]
Copyright of European Journal of Neuroscience is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Estrogen signalling and Alzheimer's disease: Decoding molecular mechanisms for therapeutic breakthrough.
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  Data: <searchLink fieldCode="AR" term="%22Rishabh%22">Rishabh</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Rohilla%2C+Manni%22">Rohilla, Manni</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Bansal%2C+Seema%22">Bansal, Seema</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Bansal%2C+Nitin%22">Bansal, Nitin</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Chauhan%2C+Samrat%22">Chauhan, Samrat</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Sharma%2C+Sheenam%22">Sharma, Sheenam</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Goyal%2C+Navjyoti%22">Goyal, Navjyoti</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Gupta%2C+Sumeet%22">Gupta, Sumeet</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22European+Journal+of+Neuroscience%22">European Journal of Neuroscience</searchLink>. Jul2024, Vol. 60 Issue 1, p3466-3490. 25p.
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  Data: <searchLink fieldCode="DE" term="%22Estrogen+receptors%22">Estrogen receptors</searchLink><br /><searchLink fieldCode="DE" term="%22Alzheimer's+disease%22">Alzheimer's disease</searchLink><br /><searchLink fieldCode="DE" term="%22Hormone+therapy%22">Hormone therapy</searchLink><br /><searchLink fieldCode="DE" term="%22Insulin-like+growth+factor+receptors%22">Insulin-like growth factor receptors</searchLink><br /><searchLink fieldCode="DE" term="%22Brain-derived+neurotrophic+factor%22">Brain-derived neurotrophic factor</searchLink><br /><searchLink fieldCode="DE" term="%22Somatomedin+C%22">Somatomedin C</searchLink><br /><searchLink fieldCode="DE" term="%22Calcium+channels%22">Calcium channels</searchLink>
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  Label: Abstract
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  Data: In females, Alzheimer's disease (AD) incidences increases as compared to males due to estrogen deficiency after menopause. Estrogen therapy is the mainstay therapy for menopause and associated complications. Estrogen, a hormone with multifaceted physiological functions, has been implicated in AD pathophysiology. Estrogen plays a crucial role in amyloid precursor protein (APP) processing and overall neuronal health by regulating various factors such as brain‐derived neurotrophic factor (BDNF), intracellular calcium signalling, death domain‐associated protein (Daxx) translocation, glutamatergic excitotoxicity, Voltage‐Dependent Anion Channel, Insulin‐Like Growth Factor 1 Receptor, estrogen‐metabolising enzymes and apolipoprotein E (ApoE) protein polymorphisms. All these factors impact the physiology of postmenopausal women. Estrogen replacement therapies play an important treatment strategy to prevent AD after menopause. However, use of these therapies may lead to increased risks of breast cancer, venous thromboembolism and cardiovascular disease. Various therapeutic approaches have been used to mitigate the effects of estrogen on AD. These include hormone replacement therapy, Selective Estrogen Receptor Modulators (SERMs), Estrogen Receptor Beta (ERβ)‐Selective Agonists, Transdermal Estrogen Delivery, Localised Estrogen Delivery, Combination Therapies, Estrogen Metabolism Modulation and Alternative Estrogenic Compounds like genistein from soy, a notable phytoestrogen from plant sources. However, mechanism via which these approaches modulate AD in postmenopausal women has not been explained earlier thoroughly. Present review will enlighten all the molecular mechanisms of estrogen and estrogen replacement therapies in AD. Along‐with this, the association between estrogen, estrogen‐metabolising enzymes and ApoE protein polymorphisms will also be discussed in postmenopausal AD. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of European Journal of Neuroscience is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Text: English
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        StartPage: 3466
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      – SubjectFull: Alzheimer's disease
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      – SubjectFull: Hormone therapy
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      – SubjectFull: Insulin-like growth factor receptors
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      – SubjectFull: Brain-derived neurotrophic factor
        Type: general
      – SubjectFull: Somatomedin C
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      – SubjectFull: Calcium channels
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              M: 07
              Text: Jul2024
              Type: published
              Y: 2024
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