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The olfactory network of larval Xenopus laevis regenerates accurately after olfactory nerve transection.

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Title: The olfactory network of larval Xenopus laevis regenerates accurately after olfactory nerve transection.
Authors: Hawkins, Sara J. (AUTHOR), Gärtner, Yvonne (AUTHOR), Offner, Thomas (AUTHOR), Weiss, Lukas (AUTHOR), Maiello, Guido (AUTHOR), Hassenklöver, Thomas (AUTHOR), Manzini, Ivan (AUTHOR)
Source: European Journal of Neuroscience. Jul2024, Vol. 60 Issue 1, p3719-3741. 23p.
Subjects: Olfactory nerve, Xenopus laevis, Olfactory receptors, Stem cells, Epithelial cells, Olfactory bulb
Abstract: Across vertebrate species, the olfactory epithelium (OE) exhibits the uncommon feature of lifelong neuronal turnover. Epithelial stem cells give rise to new neurons that can adequately replace dying olfactory receptor neurons (ORNs) during developmental and adult phases and after lesions. To relay olfactory information from the environment to the brain, the axons of the renewed ORNs must reconnect with the olfactory bulb (OB). In Xenopus laevis larvae, we have previously shown that this process occurs between 3 and 7 weeks after olfactory nerve (ON) transection. In the present study, we show that after 7 weeks of recovery from ON transection, two functionally and spatially distinct glomerular clusters are reformed in the OB, akin to those found in non‐transected larvae. We also show that the same odourant response tuning profiles observed in the OB of non‐transected larvae are again present after 7 weeks of recovery. Next, we show that characteristic odour‐guided behaviour disappears after ON transection but recovers after 7–9 weeks of recovery. Together, our findings demonstrate that the olfactory system of larval X. laevis regenerates with high accuracy after ON transection, leading to the recovery of odour‐guided behaviour. [ABSTRACT FROM AUTHOR]
Copyright of European Journal of Neuroscience is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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Items – Name: Title
  Label: Title
  Group: Ti
  Data: The olfactory network of larval Xenopus laevis regenerates accurately after olfactory nerve transection.
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  Data: <searchLink fieldCode="AR" term="%22Hawkins%2C+Sara+J%2E%22">Hawkins, Sara J.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Gärtner%2C+Yvonne%22">Gärtner, Yvonne</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Offner%2C+Thomas%22">Offner, Thomas</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Weiss%2C+Lukas%22">Weiss, Lukas</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Maiello%2C+Guido%22">Maiello, Guido</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Hassenklöver%2C+Thomas%22">Hassenklöver, Thomas</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Manzini%2C+Ivan%22">Manzini, Ivan</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22European+Journal+of+Neuroscience%22">European Journal of Neuroscience</searchLink>. Jul2024, Vol. 60 Issue 1, p3719-3741. 23p.
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  Data: <searchLink fieldCode="DE" term="%22Olfactory+nerve%22">Olfactory nerve</searchLink><br /><searchLink fieldCode="DE" term="%22Xenopus+laevis%22">Xenopus laevis</searchLink><br /><searchLink fieldCode="DE" term="%22Olfactory+receptors%22">Olfactory receptors</searchLink><br /><searchLink fieldCode="DE" term="%22Stem+cells%22">Stem cells</searchLink><br /><searchLink fieldCode="DE" term="%22Epithelial+cells%22">Epithelial cells</searchLink><br /><searchLink fieldCode="DE" term="%22Olfactory+bulb%22">Olfactory bulb</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Across vertebrate species, the olfactory epithelium (OE) exhibits the uncommon feature of lifelong neuronal turnover. Epithelial stem cells give rise to new neurons that can adequately replace dying olfactory receptor neurons (ORNs) during developmental and adult phases and after lesions. To relay olfactory information from the environment to the brain, the axons of the renewed ORNs must reconnect with the olfactory bulb (OB). In Xenopus laevis larvae, we have previously shown that this process occurs between 3 and 7 weeks after olfactory nerve (ON) transection. In the present study, we show that after 7 weeks of recovery from ON transection, two functionally and spatially distinct glomerular clusters are reformed in the OB, akin to those found in non‐transected larvae. We also show that the same odourant response tuning profiles observed in the OB of non‐transected larvae are again present after 7 weeks of recovery. Next, we show that characteristic odour‐guided behaviour disappears after ON transection but recovers after 7–9 weeks of recovery. Together, our findings demonstrate that the olfactory system of larval X. laevis regenerates with high accuracy after ON transection, leading to the recovery of odour‐guided behaviour. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of European Journal of Neuroscience is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1111/ejn.16375
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        Text: English
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      – SubjectFull: Olfactory nerve
        Type: general
      – SubjectFull: Xenopus laevis
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      – SubjectFull: Olfactory receptors
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      – SubjectFull: Stem cells
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      – TitleFull: The olfactory network of larval Xenopus laevis regenerates accurately after olfactory nerve transection.
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              M: 07
              Text: Jul2024
              Type: published
              Y: 2024
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