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There is no association between serum endotoxin levels and inflammation in asthma.

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Title: There is no association between serum endotoxin levels and inflammation in asthma.
Authors: Candan, Ozlem (AUTHOR), Toptas, Tayfur (AUTHOR), Demir, Semra (AUTHOR), Erdenen, Fusun (AUTHOR)
Source: Journal of Asthma. Aug2024, Vol. 61 Issue 8, p883-888. 6p.
Subjects: Endotoxins, Asthma, Gram-negative bacteria, Lipopolysaccharide structure, Pulmonary function tests, Wheeze
Abstract: Endotoxin, in lipopolysaccharide structure (LPS), is the main component of the outer membrane of gram negative bacteria. LPS levels were associated with inflammatory disease. Asthma is a chronic inflammatory disease involving many different cell types and cellular elements. The association between LPS serum levels and the asthma is not well known. The aim of this study was to investigate the association between the LPS serum levels and the severity of asthma, demographic data and laboratory parameters. The study included 67 patients aged >18 years with a diagnosis of asthma, and 15 healthy volunteers with no history of chronic disease as a control group. The Asthma Control Test (ACT), Respiratory Function Tests (RFTs), fractional exhaled nitric oxide (FeNO), and endotoxin levels were measured and compared between the groups. The endotoxin measurements were performed using the ELISA method. The mild-moderate asthma group included 33 patients and the severe asthma group, 34 patients. The endotoxin level was measured as 17.78 (range 3.59 to 304.55) EU/ml in the patient group and 15 (range 4.01 to 74.06) EU/ml in the control group with no statistically significant difference determined between the groups. In the subgroups, the endotoxin level was measured as 15.21 (range 3.69 to 304.55) EU/ml in the mild-moderate group and 14.46 (range 3.59 to 278.86) EU/ml in the severe asthma group with no statistically significant difference determined between the groups. The results of this study showed no relationship between serum endotoxin level and asthma or asthma severity. [ABSTRACT FROM AUTHOR]
Copyright of Journal of Asthma is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: There is no association between serum endotoxin levels and inflammation in asthma.
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  Data: <searchLink fieldCode="AR" term="%22Candan%2C+Ozlem%22">Candan, Ozlem</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Toptas%2C+Tayfur%22">Toptas, Tayfur</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Demir%2C+Semra%22">Demir, Semra</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Erdenen%2C+Fusun%22">Erdenen, Fusun</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Journal+of+Asthma%22">Journal of Asthma</searchLink>. Aug2024, Vol. 61 Issue 8, p883-888. 6p.
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  Data: <searchLink fieldCode="DE" term="%22Endotoxins%22">Endotoxins</searchLink><br /><searchLink fieldCode="DE" term="%22Asthma%22">Asthma</searchLink><br /><searchLink fieldCode="DE" term="%22Gram-negative+bacteria%22">Gram-negative bacteria</searchLink><br /><searchLink fieldCode="DE" term="%22Lipopolysaccharide+structure%22">Lipopolysaccharide structure</searchLink><br /><searchLink fieldCode="DE" term="%22Pulmonary+function+tests%22">Pulmonary function tests</searchLink><br /><searchLink fieldCode="DE" term="%22Wheeze%22">Wheeze</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Endotoxin, in lipopolysaccharide structure (LPS), is the main component of the outer membrane of gram negative bacteria. LPS levels were associated with inflammatory disease. Asthma is a chronic inflammatory disease involving many different cell types and cellular elements. The association between LPS serum levels and the asthma is not well known. The aim of this study was to investigate the association between the LPS serum levels and the severity of asthma, demographic data and laboratory parameters. The study included 67 patients aged >18 years with a diagnosis of asthma, and 15 healthy volunteers with no history of chronic disease as a control group. The Asthma Control Test (ACT), Respiratory Function Tests (RFTs), fractional exhaled nitric oxide (FeNO), and endotoxin levels were measured and compared between the groups. The endotoxin measurements were performed using the ELISA method. The mild-moderate asthma group included 33 patients and the severe asthma group, 34 patients. The endotoxin level was measured as 17.78 (range 3.59 to 304.55) EU/ml in the patient group and 15 (range 4.01 to 74.06) EU/ml in the control group with no statistically significant difference determined between the groups. In the subgroups, the endotoxin level was measured as 15.21 (range 3.69 to 304.55) EU/ml in the mild-moderate group and 14.46 (range 3.59 to 278.86) EU/ml in the severe asthma group with no statistically significant difference determined between the groups. The results of this study showed no relationship between serum endotoxin level and asthma or asthma severity. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Journal of Asthma is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1080/02770903.2024.2311233
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      – Code: eng
        Text: English
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        PageCount: 6
        StartPage: 883
    Subjects:
      – SubjectFull: Endotoxins
        Type: general
      – SubjectFull: Asthma
        Type: general
      – SubjectFull: Gram-negative bacteria
        Type: general
      – SubjectFull: Lipopolysaccharide structure
        Type: general
      – SubjectFull: Pulmonary function tests
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      – SubjectFull: Wheeze
        Type: general
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      – TitleFull: There is no association between serum endotoxin levels and inflammation in asthma.
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            NameFull: Candan, Ozlem
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            NameFull: Toptas, Tayfur
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            NameFull: Demir, Semra
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            NameFull: Erdenen, Fusun
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            – D: 01
              M: 08
              Text: Aug2024
              Type: published
              Y: 2024
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              Value: 61
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