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10 kHz stimulation as rescue therapy for spinal cord stimulation trial failure or loss of efficacy: A retrospective study.

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Title: 10 kHz stimulation as rescue therapy for spinal cord stimulation trial failure or loss of efficacy: A retrospective study.
Authors: Buonanno, Pasquale, Servillo, Giuseppe, Visser‐Vandewalle, Veerle, Matis, Georgios
Source: Pain Practice. Jul2024, Vol. 24 Issue 6, p845-851. 7p.
Subjects: Pain measurement, Chronic pain, Morphine, Treatment effectiveness, Retrospective studies, Pain threshold, Pain management, Medical records, Acquisition of data, Pain, Neural stimulation, Health outcome assessment, Spinal cord, Lumbar pain
Geographic Terms: Germany
Abstract: Introduction: Spinal cord stimulation (SCS) is currently used for the management of pain of different origin, and since its inception, many waveforms have been developed. Some patients experience no pain relief already during SCS trial, while other patients go through a loss of efficacy due to habituation after a variable period of satisfying pain control. Our retrospective study represents the first report exploring the potential role of 10 kHz stimulation as rescue therapy for patients who did not benefit not only from conventional stimulation but even from other waveforms during SCS trial or follow‐up. Methods: This study was conducted in Germany; we retrospectively enrolled patients with no pain relief during SCS trial or with loss of efficacy of other waveforms over time; and we recorded visual analogic scale (VAS), Oswestry Disability Index (ODI), and daily opioid consumption expressed as morphine milligram equivalents (MME), right before and 12 months after the switching to 10 kHz simulation. Results: The rate of successful switching to 10 kHz stimulation was comparable in patients enrolled during the SCS trial and during the follow‐up (43% vs. 40%, respectively); notably, the highest rate of failed rescue was recorded in case of persistent spinal pain syndrome (PSPS) II. Patients who responded to the switching showed a significant improvement in VAS and ODI after 12 months of treatment compared to baseline (3.6 ± 1.0 vs. 8.2 ± 0.9, p < 0.00001 and 34.0 ± 7.8 vs. 64.3 ± 8.7, p < 0.0001, respectively), whereas there was no reduction in the consumption of opioids in terms of MME (3 (0–16) vs. 5 (0–8.75), p = 0.1003). Conclusions: Rescue therapy with 10 kHz stimulation could be an important strategy to avoid SCS explant in both patients non‐responsive during trial or experiencing a loss of efficacy during the years with other waveforms. [ABSTRACT FROM AUTHOR]
Copyright of Pain Practice is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: 10 kHz stimulation as rescue therapy for spinal cord stimulation trial failure or loss of efficacy: A retrospective study.
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  Data: &lt;searchLink fieldCode=&quot;JN&quot; term=&quot;%22Pain+Practice%22&quot;&gt;Pain Practice&lt;/searchLink&gt;. Jul2024, Vol. 24 Issue 6, p845-851. 7p.
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  Data: Introduction: Spinal cord stimulation (SCS) is currently used for the management of pain of different origin, and since its inception, many waveforms have been developed. Some patients experience no pain relief already during SCS trial, while other patients go through a loss of efficacy due to habituation after a variable period of satisfying pain control. Our retrospective study represents the first report exploring the potential role of 10 kHz stimulation as rescue therapy for patients who did not benefit not only from conventional stimulation but even from other waveforms during SCS trial or follow‐up. Methods: This study was conducted in Germany; we retrospectively enrolled patients with no pain relief during SCS trial or with loss of efficacy of other waveforms over time; and we recorded visual analogic scale (VAS), Oswestry Disability Index (ODI), and daily opioid consumption expressed as morphine milligram equivalents (MME), right before and 12 months after the switching to 10 kHz simulation. Results: The rate of successful switching to 10 kHz stimulation was comparable in patients enrolled during the SCS trial and during the follow‐up (43% vs. 40%, respectively); notably, the highest rate of failed rescue was recorded in case of persistent spinal pain syndrome (PSPS) II. Patients who responded to the switching showed a significant improvement in VAS and ODI after 12 months of treatment compared to baseline (3.6 &#177; 1.0 vs. 8.2 &#177; 0.9, p &lt; 0.00001 and 34.0 &#177; 7.8 vs. 64.3 &#177; 8.7, p &lt; 0.0001, respectively), whereas there was no reduction in the consumption of opioids in terms of MME (3 (0–16) vs. 5 (0–8.75), p = 0.1003). Conclusions: Rescue therapy with 10 kHz stimulation could be an important strategy to avoid SCS explant in both patients non‐responsive during trial or experiencing a loss of efficacy during the years with other waveforms. [ABSTRACT FROM AUTHOR]
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  Data: &lt;i&gt;Copyright of Pain Practice is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder&#39;s express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.&lt;/i&gt; (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=178395254
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        Value: 10.1111/papr.13369
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        Text: English
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      – SubjectFull: Pain measurement
        Type: general
      – SubjectFull: Chronic pain
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      – SubjectFull: Morphine
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      – SubjectFull: Retrospective studies
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      – SubjectFull: Neural stimulation
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      – SubjectFull: Health outcome assessment
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      – SubjectFull: Spinal cord
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      – SubjectFull: Lumbar pain
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      – SubjectFull: Germany
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      – TitleFull: 10 kHz stimulation as rescue therapy for spinal cord stimulation trial failure or loss of efficacy: A retrospective study.
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              Text: Jul2024
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              Y: 2024
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