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Atypical neurocognitive functioning in children and adolescents with obsessive–compulsive disorder (OCD).

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Title: Atypical neurocognitive functioning in children and adolescents with obsessive–compulsive disorder (OCD).
Authors: Uhre, Camilla Funch, Ritter, Melanie, Jepsen, Jens Richardt Møllegaard, Uhre, Valdemar Funch, Lønfeldt, Nicole Nadine, Müller, Anne Dorothee, Plessen, Kerstin Jessica, Vangkilde, Signe, Blair, Robert James, Pagsberg, Anne Katrine
Source: European Child & Adolescent Psychiatry. Jul2024, Vol. 33 Issue 7, p2291-2300. 10p.
Subjects: Diagnosis of obsessive-compulsive disorder, Research funding, Executive function, Cognitive processing speed, Descriptive statistics, Decision making, Multivariate analysis, Analysis of variance, Case-control method, Intelligence tests, Short-term memory, Pathological psychology, Cognition, Adolescence, Children
Abstract: Atypical neurocognitive functioning has been found in adult patients with obsessive–compulsive disorder (OCD). However, little work has been done in children and adolescents with OCD. In this study, we investigated neurocognitive functioning in a large and representative sample of newly diagnosed children and adolescents with OCD compared to non-psychiatric controls. Children and adolescents with OCD (n = 119) and non-psychiatric controls (n = 90) underwent psychopathological assessment, intelligence testing, and a neurocognitive test battery spanning cognitive flexibility, planning and decision-making, working memory, fluency, and processing speed. The MANOVA main effect revealed that children and adolescents with OCD performed significantly worse than the control group (p <.001, η p 2 = 0.256). Atypical patient performance was particularly found for indices of cognitive flexibility, decision-making, working memory, and processing speed. We found no evidence of differences in planning or fluency. Moreover, we found no significant associations between neurocognitive performance and OCD symptom severity or comorbidity status. Our results indicate that children and adolescents with OCD show selective atypical neurocognitive functioning. These difficulties do not appear to drive their OCD symptoms. However, they may contribute to lifespan difficulties and interfere with treatment efficacy, an objective of our research currently. [ABSTRACT FROM AUTHOR]
Copyright of European Child & Adolescent Psychiatry is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Atypical neurocognitive functioning has been found in adult patients with obsessive–compulsive disorder (OCD). However, little work has been done in children and adolescents with OCD. In this study, we investigated neurocognitive functioning in a large and representative sample of newly diagnosed children and adolescents with OCD compared to non-psychiatric controls. Children and adolescents with OCD (n = 119) and non-psychiatric controls (n = 90) underwent psychopathological assessment, intelligence testing, and a neurocognitive test battery spanning cognitive flexibility, planning and decision-making, working memory, fluency, and processing speed. The MANOVA main effect revealed that children and adolescents with OCD performed significantly worse than the control group (p &lt;.001, η p 2 = 0.256). Atypical patient performance was particularly found for indices of cognitive flexibility, decision-making, working memory, and processing speed. We found no evidence of differences in planning or fluency. Moreover, we found no significant associations between neurocognitive performance and OCD symptom severity or comorbidity status. Our results indicate that children and adolescents with OCD show selective atypical neurocognitive functioning. These difficulties do not appear to drive their OCD symptoms. However, they may contribute to lifespan difficulties and interfere with treatment efficacy, an objective of our research currently. [ABSTRACT FROM AUTHOR]
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  Data: &lt;i&gt;Copyright of European Child &amp; Adolescent Psychiatry is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder&#39;s express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.&lt;/i&gt; (Copyright applies to all Abstracts.)
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        Value: 10.1007/s00787-023-02301-w
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      – Code: eng
        Text: English
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      – SubjectFull: Diagnosis of obsessive-compulsive disorder
        Type: general
      – SubjectFull: Research funding
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      – SubjectFull: Executive function
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      – SubjectFull: Cognitive processing speed
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      – SubjectFull: Descriptive statistics
        Type: general
      – SubjectFull: Decision making
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      – SubjectFull: Multivariate analysis
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              Text: Jul2024
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