View in EDS HTML Full Text PDF Full Text

Association between renal insufficiency and lesion characteristics of posterior reversible encephalopathy syndrome.

Saved in:
Bibliographic Details
Title: Association between renal insufficiency and lesion characteristics of posterior reversible encephalopathy syndrome.
Authors: Jeong, Dong Young (AUTHOR), Shin, Yea Na (AUTHOR), Ha, Sang Hee (AUTHOR), Chang, Jun Young (AUTHOR), Kang, Dong-Wha (AUTHOR), Kwon, Sun U. (AUTHOR), Kim, Bum Joon (AUTHOR)
Source: Neurological Sciences. Aug2024, Vol. 45 Issue 8, p3907-3915. 9p.
Subjects: Posterior leukoencephalopathy syndrome, Kidney failure, Cerebral circulation, Multiple regression analysis
Abstract: Background: Posterior reversible encephalopathy syndrome (PRES) is characterized by cerebral blood flow dysregulation and the blood–brain barrier (BBB) disruption. While renal insufficiency has been considered a factor in BBB fragility, the relationship between renal insufficiency and the PRES lesions volume remains unclear. Methods: This observational study was performed retrospectively. PRES patients were categorized into two groups with renal insufficiency, defined as an estimated glomerular filtration rate (eGFR) of less than 60 mL/min/1.73m2 on the day of symptom occurrence. Lesion volume was measured using fluid-attenuated inversion recovery (FLAIR) imaging, and the brain was divided into nine regions. The volume of the parietal-occipital-temporal lobe was considered typical, while the other six regions were labeled as atypical. Results: The study included 200 patients, of whom 94 (47%) had renal insufficiency. Patients with renal insufficiency had a larger lesion volume (144.7 ± 125.2 cc) compared to those without renal insufficiency (110.5 ± 93.2 cc; p = 0.032); particularly in the atypical lesions volume (49.2 ± 65.0 vs. 29.2 ± 44.3 cc; p = 0.013). However, there was no difference in the reversibility of the lesions (35.2 ± 67.5 vs. 18.8 ± 33.4 cc; p = 0.129). Multiple regression analysis revealed that decreases in eGFR (β = -0.34, 95% CI -0.62-0.05, p = 0.020) were positively associated with total lesion volume. Conclusion: Our findings suggest that PRES patients with renal insufficiency experience more severe lesion volumes, likely due to the atypical brain regions involvement. The lesions involving atypical regions may have a similar pathophysiology to typical lesions, as the PRES lesions reversibility was found to be similar between individuals with and without renal insufficiency. [ABSTRACT FROM AUTHOR]
Copyright of Neurological Sciences is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
Full text is not displayed to guests.
FullText Links:
  – Type: pdflink
Text:
  Availability: 1
Header DbId: pbh
DbLabel: Psychology and Behavioral Sciences Collection
An: 178484328
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Association between renal insufficiency and lesion characteristics of posterior reversible encephalopathy syndrome.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Jeong%2C+Dong+Young%22">Jeong, Dong Young</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Shin%2C+Yea+Na%22">Shin, Yea Na</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ha%2C+Sang+Hee%22">Ha, Sang Hee</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Chang%2C+Jun+Young%22">Chang, Jun Young</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kang%2C+Dong-Wha%22">Kang, Dong-Wha</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kwon%2C+Sun+U%2E%22">Kwon, Sun U.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kim%2C+Bum+Joon%22">Kim, Bum Joon</searchLink> (AUTHOR)
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22Neurological+Sciences%22">Neurological Sciences</searchLink>. Aug2024, Vol. 45 Issue 8, p3907-3915. 9p.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Posterior+leukoencephalopathy+syndrome%22">Posterior leukoencephalopathy syndrome</searchLink><br /><searchLink fieldCode="DE" term="%22Kidney+failure%22">Kidney failure</searchLink><br /><searchLink fieldCode="DE" term="%22Cerebral+circulation%22">Cerebral circulation</searchLink><br /><searchLink fieldCode="DE" term="%22Multiple+regression+analysis%22">Multiple regression analysis</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Background: Posterior reversible encephalopathy syndrome (PRES) is characterized by cerebral blood flow dysregulation and the blood–brain barrier (BBB) disruption. While renal insufficiency has been considered a factor in BBB fragility, the relationship between renal insufficiency and the PRES lesions volume remains unclear. Methods: This observational study was performed retrospectively. PRES patients were categorized into two groups with renal insufficiency, defined as an estimated glomerular filtration rate (eGFR) of less than 60 mL/min/1.73m2 on the day of symptom occurrence. Lesion volume was measured using fluid-attenuated inversion recovery (FLAIR) imaging, and the brain was divided into nine regions. The volume of the parietal-occipital-temporal lobe was considered typical, while the other six regions were labeled as atypical. Results: The study included 200 patients, of whom 94 (47%) had renal insufficiency. Patients with renal insufficiency had a larger lesion volume (144.7 ± 125.2 cc) compared to those without renal insufficiency (110.5 ± 93.2 cc; p = 0.032); particularly in the atypical lesions volume (49.2 ± 65.0 vs. 29.2 ± 44.3 cc; p = 0.013). However, there was no difference in the reversibility of the lesions (35.2 ± 67.5 vs. 18.8 ± 33.4 cc; p = 0.129). Multiple regression analysis revealed that decreases in eGFR (β = -0.34, 95% CI -0.62-0.05, p = 0.020) were positively associated with total lesion volume. Conclusion: Our findings suggest that PRES patients with renal insufficiency experience more severe lesion volumes, likely due to the atypical brain regions involvement. The lesions involving atypical regions may have a similar pathophysiology to typical lesions, as the PRES lesions reversibility was found to be similar between individuals with and without renal insufficiency. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Neurological Sciences is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=178484328
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1007/s10072-024-07446-3
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 9
        StartPage: 3907
    Subjects:
      – SubjectFull: Posterior leukoencephalopathy syndrome
        Type: general
      – SubjectFull: Kidney failure
        Type: general
      – SubjectFull: Cerebral circulation
        Type: general
      – SubjectFull: Multiple regression analysis
        Type: general
    Titles:
      – TitleFull: Association between renal insufficiency and lesion characteristics of posterior reversible encephalopathy syndrome.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Jeong, Dong Young
      – PersonEntity:
          Name:
            NameFull: Shin, Yea Na
      – PersonEntity:
          Name:
            NameFull: Ha, Sang Hee
      – PersonEntity:
          Name:
            NameFull: Chang, Jun Young
      – PersonEntity:
          Name:
            NameFull: Kang, Dong-Wha
      – PersonEntity:
          Name:
            NameFull: Kwon, Sun U.
      – PersonEntity:
          Name:
            NameFull: Kim, Bum Joon
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 08
              Text: Aug2024
              Type: published
              Y: 2024
          Identifiers:
            – Type: issn-print
              Value: 15901874
          Numbering:
            – Type: volume
              Value: 45
            – Type: issue
              Value: 8
          Titles:
            – TitleFull: Neurological Sciences
              Type: main
ResultId 1