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High mortality in adolescents and young adults with perinatally-acquired HIV in Thailand during the transition to adulthood.

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Title: High mortality in adolescents and young adults with perinatally-acquired HIV in Thailand during the transition to adulthood.
Authors: Ounchanum, Pradthana, Aurpibul, Linda, Teeraananchai, Sirinya, Lumbiganon, Pagakrong, Songtaweesin, Wipaporn Natalie, Sudjaritruk, Tavitiya, Chokephaibulkit, Kulkanya, Rungmaitree, Supattra, Kosalaraksa, Pope, Suwanlerk, Tulathip, Ross, Jeremy L., Sohn, Annette H., Puthanakit on behalf of the Thai PAPAYA study team, Thanyawee
Source: AIDS Care. Jul2024, Vol. 36 Issue 7, p964-973. 10p.
Subjects: Infectious disease transmission, HIV infection prognosis, HIV integrase inhibitors, Research funding, HIV-positive persons, Questionnaires, HIV infections, Treatment effectiveness, Descriptive statistics, Patient care, Longitudinal method, Protease inhibitors, Vertical transmission (Communicable diseases), Reverse transcriptase inhibitors, Medical records, Acquisition of data, Anti-HIV agents, Survival analysis (Biometry), Confidence intervals, Transition to adulthood, AIDS, Adolescence, Adults
Geographic Terms: Thailand
Abstract: Transitioning from pediatric to adult care remains a challenge for adolescents and young adults with perinatally-acquired HIV (AYA-PHIV). We assessed treatment outcomes and mortality among Thai AYA-PHIV. The study included AYA-PHIV who reached age 18–24 years who started antiretroviral treatment during childhood at five pediatric HIV clinics across Thailand. From November 2020–July 2021, data were gathered from a cohort database, medical records, and the Thai National AIDS Program. Of 811 eligible AYA-PHIV, 93% were alive; median age 22.3 years (IQR 20.6–23.7), treatment duration 16.1 years (IQR 13.4–18.0). Current HIV care was provided in adults (71%) and pediatric clinics (29%). Treatment regimens included non-nucleoside reverse transcriptase inhibitors (55%), protease inhibitors (36%), and integrase inhibitors (8%); 78% had HIV RNA <200 copies/ml. Of the 7.0% who died, median age at death was 20.8 years (IQR 20.6–22.1); 88% were AIDS-related death. Mortality after age 18 was 1.76 per 100-person years (95% confidence interval 1.36–2.28). Those with CD4 <200 cell/mm3 at age 15 had higher risk of mortality (adjusted hazard ratio 6.16, 95% CI 2.37–16.02). In conclusion, the high mortality among Thai AYA-PHIV indicated the need for better systems to support AYA-PHIV during the transition to adulthood. [ABSTRACT FROM AUTHOR]
Copyright of AIDS Care is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: High mortality in adolescents and young adults with perinatally-acquired HIV in Thailand during the transition to adulthood.
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  Data: &lt;searchLink fieldCode=&quot;JN&quot; term=&quot;%22AIDS+Care%22&quot;&gt;AIDS Care&lt;/searchLink&gt;. Jul2024, Vol. 36 Issue 7, p964-973. 10p.
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  Data: Transitioning from pediatric to adult care remains a challenge for adolescents and young adults with perinatally-acquired HIV (AYA-PHIV). We assessed treatment outcomes and mortality among Thai AYA-PHIV. The study included AYA-PHIV who reached age 18–24 years who started antiretroviral treatment during childhood at five pediatric HIV clinics across Thailand. From November 2020–July 2021, data were gathered from a cohort database, medical records, and the Thai National AIDS Program. Of 811 eligible AYA-PHIV, 93% were alive; median age 22.3 years (IQR 20.6–23.7), treatment duration 16.1 years (IQR 13.4–18.0). Current HIV care was provided in adults (71%) and pediatric clinics (29%). Treatment regimens included non-nucleoside reverse transcriptase inhibitors (55%), protease inhibitors (36%), and integrase inhibitors (8%); 78% had HIV RNA &lt;200 copies/ml. Of the 7.0% who died, median age at death was 20.8 years (IQR 20.6–22.1); 88% were AIDS-related death. Mortality after age 18 was 1.76 per 100-person years (95% confidence interval 1.36–2.28). Those with CD4 &lt;200 cell/mm3 at age 15 had higher risk of mortality (adjusted hazard ratio 6.16, 95% CI 2.37–16.02). In conclusion, the high mortality among Thai AYA-PHIV indicated the need for better systems to support AYA-PHIV during the transition to adulthood. [ABSTRACT FROM AUTHOR]
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  Data: &lt;i&gt;Copyright of AIDS Care is the property of Taylor &amp; Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder&#39;s express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.&lt;/i&gt; (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=178651956
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      – Type: doi
        Value: 10.1080/09540121.2024.2325100
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      – Code: eng
        Text: English
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      Pagination:
        PageCount: 10
        StartPage: 964
    Subjects:
      – SubjectFull: Infectious disease transmission
        Type: general
      – SubjectFull: HIV infection prognosis
        Type: general
      – SubjectFull: HIV integrase inhibitors
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      – SubjectFull: Research funding
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      – SubjectFull: HIV-positive persons
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      – SubjectFull: Questionnaires
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      – SubjectFull: HIV infections
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      – SubjectFull: Treatment effectiveness
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      – SubjectFull: Descriptive statistics
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      – SubjectFull: Patient care
        Type: general
      – SubjectFull: Longitudinal method
        Type: general
      – SubjectFull: Protease inhibitors
        Type: general
      – SubjectFull: Vertical transmission (Communicable diseases)
        Type: general
      – SubjectFull: Reverse transcriptase inhibitors
        Type: general
      – SubjectFull: Medical records
        Type: general
      – SubjectFull: Acquisition of data
        Type: general
      – SubjectFull: Anti-HIV agents
        Type: general
      – SubjectFull: Survival analysis (Biometry)
        Type: general
      – SubjectFull: Confidence intervals
        Type: general
      – SubjectFull: Transition to adulthood
        Type: general
      – SubjectFull: AIDS
        Type: general
      – SubjectFull: Adolescence
        Type: general
      – SubjectFull: Adults
        Type: general
      – SubjectFull: Thailand
        Type: general
    Titles:
      – TitleFull: High mortality in adolescents and young adults with perinatally-acquired HIV in Thailand during the transition to adulthood.
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              Text: Jul2024
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