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Amygdala-related electrical fingerprint is modulated with neurofeedback training and correlates with deep-brain activation: proof-of-concept in borderline personality disorder.

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Title: Amygdala-related electrical fingerprint is modulated with neurofeedback training and correlates with deep-brain activation: proof-of-concept in borderline personality disorder.
Authors: Zopfs, Malte, Jindrová, Miroslava, Gurevitch, Guy, Keynan, Jackob N., Hendler, Talma, Baumeister, Sarah, Aggensteiner, Pascal-M., Cornelisse, Sven, Brandeis, Daniel, Schmahl, Christian, Paret, Christian
Source: Psychological Medicine. Jun2024, Vol. 54 Issue 8, p1651-1660. 10p.
Subjects: Treatment of borderline personality disorder, Emotion regulation, Post-traumatic stress disorder, Amygdaloid body, Electroencephalography, Replication (Experimental design), Pilot projects, Brain, Deep brain stimulation, Biofeedback training, Magnetic resonance imaging, Borderline personality disorder, Dialectical behavior therapy, Computer-aided diagnosis, Neuroradiology, Affect (Psychology), Brain mapping, Pathological psychology, Regression analysis, Electrodes, Cognition
Abstract: Background: The modulation of brain circuits of emotion is a promising pathway to treat borderline personality disorder (BPD). Precise and scalable approaches have yet to be established. Two studies investigating the amygdala-related electrical fingerprint (Amyg-EFP) in BPD are presented: one study addressing the deep-brain correlates of Amyg-EFP, and a second study investigating neurofeedback (NF) as a means to improve brain self-regulation. Methods: Study 1 combined electroencephalography (EEG) and simultaneous functional magnetic resonance imaging to investigate the replicability of Amyg-EFP-related brain activation found in the reference dataset (N = 24 healthy subjects, 8 female; re-analysis of published data) in the replication dataset (N = 16 female individuals with BPD). In the replication dataset, we additionally explored how the Amyg-EFP would map to neural circuits defined by the research domain criteria. Study 2 investigated a 10-session Amyg-EFP NF training in parallel to a 12-weeks residential dialectical behavior therapy (DBT) program. Fifteen patients with BPD completed the training, N = 15 matched patients served as DBT-only controls. Results: Study 1 replicated previous findings and showed significant amygdala blood oxygenation level dependent activation in a whole-brain regression analysis with the Amyg-EFP. Neurocircuitry activation (negative affect, salience, and cognitive control) was correlated with the Amyg-EFP signal. Study 2 showed Amyg-EFP modulation with NF training, but patients received reversed feedback for technical reasons, which limited interpretation of results. Conclusions: Recorded via scalp EEG, the Amyg-EFP picks up brain activation of high relevance for emotion. Administering Amyg-EFP NF in addition to standardized BPD treatment was shown to be feasible. Clinical utility remains to be investigated. [ABSTRACT FROM AUTHOR]
Copyright of Psychological Medicine is the property of Cambridge University Press and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Amygdala-related electrical fingerprint is modulated with neurofeedback training and correlates with deep-brain activation: proof-of-concept in borderline personality disorder.
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  Data: <searchLink fieldCode="AR" term="%22Zopfs%2C+Malte%22">Zopfs, Malte</searchLink><br /><searchLink fieldCode="AR" term="%22Jindrová%2C+Miroslava%22">Jindrová, Miroslava</searchLink><br /><searchLink fieldCode="AR" term="%22Gurevitch%2C+Guy%22">Gurevitch, Guy</searchLink><br /><searchLink fieldCode="AR" term="%22Keynan%2C+Jackob+N%2E%22">Keynan, Jackob N.</searchLink><br /><searchLink fieldCode="AR" term="%22Hendler%2C+Talma%22">Hendler, Talma</searchLink><br /><searchLink fieldCode="AR" term="%22Baumeister%2C+Sarah%22">Baumeister, Sarah</searchLink><br /><searchLink fieldCode="AR" term="%22Aggensteiner%2C+Pascal-M%2E%22">Aggensteiner, Pascal-M.</searchLink><br /><searchLink fieldCode="AR" term="%22Cornelisse%2C+Sven%22">Cornelisse, Sven</searchLink><br /><searchLink fieldCode="AR" term="%22Brandeis%2C+Daniel%22">Brandeis, Daniel</searchLink><br /><searchLink fieldCode="AR" term="%22Schmahl%2C+Christian%22">Schmahl, Christian</searchLink><br /><searchLink fieldCode="AR" term="%22Paret%2C+Christian%22">Paret, Christian</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22Psychological+Medicine%22">Psychological Medicine</searchLink>. Jun2024, Vol. 54 Issue 8, p1651-1660. 10p.
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  Data: <searchLink fieldCode="DE" term="%22Treatment+of+borderline+personality+disorder%22">Treatment of borderline personality disorder</searchLink><br /><searchLink fieldCode="DE" term="%22Emotion+regulation%22">Emotion regulation</searchLink><br /><searchLink fieldCode="DE" term="%22Post-traumatic+stress+disorder%22">Post-traumatic stress disorder</searchLink><br /><searchLink fieldCode="DE" term="%22Amygdaloid+body%22">Amygdaloid body</searchLink><br /><searchLink fieldCode="DE" term="%22Electroencephalography%22">Electroencephalography</searchLink><br /><searchLink fieldCode="DE" term="%22Replication+%28Experimental+design%29%22">Replication (Experimental design)</searchLink><br /><searchLink fieldCode="DE" term="%22Pilot+projects%22">Pilot projects</searchLink><br /><searchLink fieldCode="DE" term="%22Brain%22">Brain</searchLink><br /><searchLink fieldCode="DE" term="%22Deep+brain+stimulation%22">Deep brain stimulation</searchLink><br /><searchLink fieldCode="DE" term="%22Biofeedback+training%22">Biofeedback training</searchLink><br /><searchLink fieldCode="DE" term="%22Magnetic+resonance+imaging%22">Magnetic resonance imaging</searchLink><br /><searchLink fieldCode="DE" term="%22Borderline+personality+disorder%22">Borderline personality disorder</searchLink><br /><searchLink fieldCode="DE" term="%22Dialectical+behavior+therapy%22">Dialectical behavior therapy</searchLink><br /><searchLink fieldCode="DE" term="%22Computer-aided+diagnosis%22">Computer-aided diagnosis</searchLink><br /><searchLink fieldCode="DE" term="%22Neuroradiology%22">Neuroradiology</searchLink><br /><searchLink fieldCode="DE" term="%22Affect+%28Psychology%29%22">Affect (Psychology)</searchLink><br /><searchLink fieldCode="DE" term="%22Brain+mapping%22">Brain mapping</searchLink><br /><searchLink fieldCode="DE" term="%22Pathological+psychology%22">Pathological psychology</searchLink><br /><searchLink fieldCode="DE" term="%22Regression+analysis%22">Regression analysis</searchLink><br /><searchLink fieldCode="DE" term="%22Electrodes%22">Electrodes</searchLink><br /><searchLink fieldCode="DE" term="%22Cognition%22">Cognition</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Background: The modulation of brain circuits of emotion is a promising pathway to treat borderline personality disorder (BPD). Precise and scalable approaches have yet to be established. Two studies investigating the amygdala-related electrical fingerprint (Amyg-EFP) in BPD are presented: one study addressing the deep-brain correlates of Amyg-EFP, and a second study investigating neurofeedback (NF) as a means to improve brain self-regulation. Methods: Study 1 combined electroencephalography (EEG) and simultaneous functional magnetic resonance imaging to investigate the replicability of Amyg-EFP-related brain activation found in the reference dataset (N = 24 healthy subjects, 8 female; re-analysis of published data) in the replication dataset (N = 16 female individuals with BPD). In the replication dataset, we additionally explored how the Amyg-EFP would map to neural circuits defined by the research domain criteria. Study 2 investigated a 10-session Amyg-EFP NF training in parallel to a 12-weeks residential dialectical behavior therapy (DBT) program. Fifteen patients with BPD completed the training, N = 15 matched patients served as DBT-only controls. Results: Study 1 replicated previous findings and showed significant amygdala blood oxygenation level dependent activation in a whole-brain regression analysis with the Amyg-EFP. Neurocircuitry activation (negative affect, salience, and cognitive control) was correlated with the Amyg-EFP signal. Study 2 showed Amyg-EFP modulation with NF training, but patients received reversed feedback for technical reasons, which limited interpretation of results. Conclusions: Recorded via scalp EEG, the Amyg-EFP picks up brain activation of high relevance for emotion. Administering Amyg-EFP NF in addition to standardized BPD treatment was shown to be feasible. Clinical utility remains to be investigated. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Psychological Medicine is the property of Cambridge University Press and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1017/S0033291723003549
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        Text: English
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      – SubjectFull: Treatment of borderline personality disorder
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              Text: Jun2024
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