Neuropsychological performances in patients with infiltrative non-GBM gliomas after postoperative adjuvant photon or proton radiotherapy: A prospective and preliminary investigation.
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| Title: | Neuropsychological performances in patients with infiltrative non-GBM gliomas after postoperative adjuvant photon or proton radiotherapy: A prospective and preliminary investigation. |
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| Authors: | Lin, Shinn-Yn (AUTHOR), Chuang, Chi-Cheng (AUTHOR), Huang, Yin-Cheng (AUTHOR), Pai, Ping-Ching (AUTHOR), Lee, Cheng-Chi (AUTHOR), Wei, Kuo-Chen (AUTHOR), Tseng, Chen-Kan (AUTHOR), Yang, Chi-Cheng (AUTHOR) |
| Source: | Applied Neuropsychology: Adult. Jul/Aug2024, Vol. 31 Issue 4, p606-615. 10p. |
| Subjects: | Cognitive processing speed, Executive function, Verbal memory, Magnetic resonance imaging, Visual memory, Episodic memory |
| Abstract: | Infiltrative non-GBM gliomas are common primary intracranial malignancies, and postoperative adjuvant radiotherapy is recommended for most adult patients diagnosed with this disease to enhance local control and prolong intracranial progression-free survival (PFS). However, RT-related neurocognitive function (NCF) consequences should not be ignored. Early neurocognitive decline principally includes episodic memory, associated significantly with functions of the hippocampus. This prospective study aims to investigate the impact of adjuvant brain irradiation on neurocognitive performances and relevant oncological outcomes. Twenty-five patients with intracranial infiltrative non-GBM gliomas were enrolled when postoperative adjuvant RT was recommended. All recruited patients should receive baseline brain magnetic resonance imaging, and neuropsychological assessments before and 4 months after the RT course. A battery of neuropsychological measures, mainly including executive functions, memory, psychomotor speed and visuoconstructive ability, was used to evaluate NCFs of interest. Analyzing the delta values between post-irradiation and baseline NCF scores, we observed a robust trend reflecting cognitive stabilization rather than deterioration in almost all NCF. Both verbal and visual memory functions exhibited significant differences in the corresponding scaled scores (Z = −2.722, p =.006, regarding verbal memory; Z = −2.246, p =.025, concerning non-verbal memory). Moreover, patients' neuropsychological performances associated with psychomotor speed and executive functions also disclosed a tendency toward stabilization/improvement. This prospective study demonstrated that patients with infiltrative non-GBM exhibited a marked tendency toward neurocognitive stabilization after receiving postoperative adjuvant RT. Clinical trial registration: Trial Registration with ClinicalTrials.gov identifier: NCT03534050 [ABSTRACT FROM AUTHOR] |
| Copyright of Applied Neuropsychology: Adult is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 178855372 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Neuropsychological performances in patients with infiltrative non-GBM gliomas after postoperative adjuvant photon or proton radiotherapy: A prospective and preliminary investigation. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Lin%2C+Shinn-Yn%22">Lin, Shinn-Yn</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Chuang%2C+Chi-Cheng%22">Chuang, Chi-Cheng</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Huang%2C+Yin-Cheng%22">Huang, Yin-Cheng</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Pai%2C+Ping-Ching%22">Pai, Ping-Ching</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lee%2C+Cheng-Chi%22">Lee, Cheng-Chi</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Wei%2C+Kuo-Chen%22">Wei, Kuo-Chen</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Tseng%2C+Chen-Kan%22">Tseng, Chen-Kan</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Yang%2C+Chi-Cheng%22">Yang, Chi-Cheng</searchLink> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Applied+Neuropsychology%3A+Adult%22">Applied Neuropsychology: Adult</searchLink>. Jul/Aug2024, Vol. 31 Issue 4, p606-615. 10p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Cognitive+processing+speed%22">Cognitive processing speed</searchLink><br /><searchLink fieldCode="DE" term="%22Executive+function%22">Executive function</searchLink><br /><searchLink fieldCode="DE" term="%22Verbal+memory%22">Verbal memory</searchLink><br /><searchLink fieldCode="DE" term="%22Magnetic+resonance+imaging%22">Magnetic resonance imaging</searchLink><br /><searchLink fieldCode="DE" term="%22Visual+memory%22">Visual memory</searchLink><br /><searchLink fieldCode="DE" term="%22Episodic+memory%22">Episodic memory</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Infiltrative non-GBM gliomas are common primary intracranial malignancies, and postoperative adjuvant radiotherapy is recommended for most adult patients diagnosed with this disease to enhance local control and prolong intracranial progression-free survival (PFS). However, RT-related neurocognitive function (NCF) consequences should not be ignored. Early neurocognitive decline principally includes episodic memory, associated significantly with functions of the hippocampus. This prospective study aims to investigate the impact of adjuvant brain irradiation on neurocognitive performances and relevant oncological outcomes. Twenty-five patients with intracranial infiltrative non-GBM gliomas were enrolled when postoperative adjuvant RT was recommended. All recruited patients should receive baseline brain magnetic resonance imaging, and neuropsychological assessments before and 4 months after the RT course. A battery of neuropsychological measures, mainly including executive functions, memory, psychomotor speed and visuoconstructive ability, was used to evaluate NCFs of interest. Analyzing the delta values between post-irradiation and baseline NCF scores, we observed a robust trend reflecting cognitive stabilization rather than deterioration in almost all NCF. Both verbal and visual memory functions exhibited significant differences in the corresponding scaled scores (Z = −2.722, p =.006, regarding verbal memory; Z = −2.246, p =.025, concerning non-verbal memory). Moreover, patients' neuropsychological performances associated with psychomotor speed and executive functions also disclosed a tendency toward stabilization/improvement. This prospective study demonstrated that patients with infiltrative non-GBM exhibited a marked tendency toward neurocognitive stabilization after receiving postoperative adjuvant RT. Clinical trial registration: Trial Registration with ClinicalTrials.gov identifier: NCT03534050 [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Applied Neuropsychology: Adult is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1080/23279095.2022.2048830 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 10 StartPage: 606 Subjects: – SubjectFull: Cognitive processing speed Type: general – SubjectFull: Executive function Type: general – SubjectFull: Verbal memory Type: general – SubjectFull: Magnetic resonance imaging Type: general – SubjectFull: Visual memory Type: general – SubjectFull: Episodic memory Type: general Titles: – TitleFull: Neuropsychological performances in patients with infiltrative non-GBM gliomas after postoperative adjuvant photon or proton radiotherapy: A prospective and preliminary investigation. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Lin, Shinn-Yn – PersonEntity: Name: NameFull: Chuang, Chi-Cheng – PersonEntity: Name: NameFull: Huang, Yin-Cheng – PersonEntity: Name: NameFull: Pai, Ping-Ching – PersonEntity: Name: NameFull: Lee, Cheng-Chi – PersonEntity: Name: NameFull: Wei, Kuo-Chen – PersonEntity: Name: NameFull: Tseng, Chen-Kan – PersonEntity: Name: NameFull: Yang, Chi-Cheng IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 07 Text: Jul/Aug2024 Type: published Y: 2024 Identifiers: – Type: issn-print Value: 23279095 Numbering: – Type: volume Value: 31 – Type: issue Value: 4 Titles: – TitleFull: Applied Neuropsychology: Adult Type: main |
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