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Hearing dysfunction heralds an increase in non-motor burden and a worse quality of life in Parkinson's disease: new insights from non-motor spectrum.

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Title: Hearing dysfunction heralds an increase in non-motor burden and a worse quality of life in Parkinson's disease: new insights from non-motor spectrum.
Authors: Garasto, Elena (AUTHOR), Stefani, Alessandro (AUTHOR), Pierantozzi, Mariangela (AUTHOR), Conti, Matteo (AUTHOR), Moleti, Arturo (AUTHOR), Sisto, Renata (AUTHOR), Viziano, Andrea (AUTHOR), Liguori, Claudio (AUTHOR), Schirinzi, Tommaso (AUTHOR), Mercuri, Nicola Biagio (AUTHOR), Cerroni, Rocco (AUTHOR)
Source: Neurological Sciences. Sep2024, Vol. 45 Issue 9, p4299-4307. 9p.
Subjects: Parkinson's disease, Asymptomatic patients, Otoacoustic emissions, Global burden of disease, Hearing disorders, Neuroleptic malignant syndrome
Abstract: Background: Sensorial non-motor symptoms (NMSs) in Parkinson's disease (PD) still lack appropriate investigation in clinical practice. This study aimed to assess if and to what extent auditory dysfunction is associated with other NMSs in PD and its impact on patient's quality of life (QoL). Methods: We selected patients with idiopathic PD, without other concomitant neurological diseases, dementia, or diagnosis of any audiological/vestibular disease. Demographic and clinical data were collected. Patients underwent otoscopic examination, audiological testing with pure tone audiometry (PTA) and distortion product otoacoustic emissions (DPOAEs) and completed Non-Motor Symptoms Scale (NMSS) and Parkinson's Disease Questionnaires-39 (PDQ-39). ANCOVA and partial correlation analysis have been used for statistical analysis. Results: 60 patients were enrolled and completed PTA and DPOAEs. 32 patients with hearing impairment (HI), assessed by PTA, (hearing threshold ≥ 25 dB) showed similar disease duration, motor impairment, and staging, compared to patients without HI, but higher scores both in NMSS and in PDQ-39, except for cardiovascular (CV), gastrointestinal (GI), urogenital (U) and sexual function (SF) of NMSS. In addition, DPOAEs showed a significant correlation with higher scores both in NMSS and PDQ-39, except for CV, SF, GI, U and perceptual problem subdomains of NMSS. Conclusion: This study demonstrated that PD patients with HI have a greater burden of NMS and lower related QoL and functioning. Our results highlight the importance to reconsider HI as a NMS, in parallel with the others. HI evaluation, even in asymptomatic patients, may reveal a wider pathology with a worse QoL. [ABSTRACT FROM AUTHOR]
Copyright of Neurological Sciences is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Hearing dysfunction heralds an increase in non-motor burden and a worse quality of life in Parkinson's disease: new insights from non-motor spectrum.
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  Data: <searchLink fieldCode="AR" term="%22Garasto%2C+Elena%22">Garasto, Elena</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Stefani%2C+Alessandro%22">Stefani, Alessandro</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Pierantozzi%2C+Mariangela%22">Pierantozzi, Mariangela</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Conti%2C+Matteo%22">Conti, Matteo</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Moleti%2C+Arturo%22">Moleti, Arturo</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Sisto%2C+Renata%22">Sisto, Renata</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Viziano%2C+Andrea%22">Viziano, Andrea</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Liguori%2C+Claudio%22">Liguori, Claudio</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Schirinzi%2C+Tommaso%22">Schirinzi, Tommaso</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Mercuri%2C+Nicola+Biagio%22">Mercuri, Nicola Biagio</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Cerroni%2C+Rocco%22">Cerroni, Rocco</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Neurological+Sciences%22">Neurological Sciences</searchLink>. Sep2024, Vol. 45 Issue 9, p4299-4307. 9p.
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  Data: <searchLink fieldCode="DE" term="%22Parkinson's+disease%22">Parkinson's disease</searchLink><br /><searchLink fieldCode="DE" term="%22Asymptomatic+patients%22">Asymptomatic patients</searchLink><br /><searchLink fieldCode="DE" term="%22Otoacoustic+emissions%22">Otoacoustic emissions</searchLink><br /><searchLink fieldCode="DE" term="%22Global+burden+of+disease%22">Global burden of disease</searchLink><br /><searchLink fieldCode="DE" term="%22Hearing+disorders%22">Hearing disorders</searchLink><br /><searchLink fieldCode="DE" term="%22Neuroleptic+malignant+syndrome%22">Neuroleptic malignant syndrome</searchLink>
– Name: Abstract
  Label: Abstract
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  Data: Background: Sensorial non-motor symptoms (NMSs) in Parkinson's disease (PD) still lack appropriate investigation in clinical practice. This study aimed to assess if and to what extent auditory dysfunction is associated with other NMSs in PD and its impact on patient's quality of life (QoL). Methods: We selected patients with idiopathic PD, without other concomitant neurological diseases, dementia, or diagnosis of any audiological/vestibular disease. Demographic and clinical data were collected. Patients underwent otoscopic examination, audiological testing with pure tone audiometry (PTA) and distortion product otoacoustic emissions (DPOAEs) and completed Non-Motor Symptoms Scale (NMSS) and Parkinson's Disease Questionnaires-39 (PDQ-39). ANCOVA and partial correlation analysis have been used for statistical analysis. Results: 60 patients were enrolled and completed PTA and DPOAEs. 32 patients with hearing impairment (HI), assessed by PTA, (hearing threshold ≥ 25 dB) showed similar disease duration, motor impairment, and staging, compared to patients without HI, but higher scores both in NMSS and in PDQ-39, except for cardiovascular (CV), gastrointestinal (GI), urogenital (U) and sexual function (SF) of NMSS. In addition, DPOAEs showed a significant correlation with higher scores both in NMSS and PDQ-39, except for CV, SF, GI, U and perceptual problem subdomains of NMSS. Conclusion: This study demonstrated that PD patients with HI have a greater burden of NMS and lower related QoL and functioning. Our results highlight the importance to reconsider HI as a NMS, in parallel with the others. HI evaluation, even in asymptomatic patients, may reveal a wider pathology with a worse QoL. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Neurological Sciences is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1007/s10072-024-07487-8
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      – SubjectFull: Parkinson's disease
        Type: general
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      – SubjectFull: Otoacoustic emissions
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              Text: Sep2024
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