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Oromandibular dystonia: from onset to spread a multicenter italian study.

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Title: Oromandibular dystonia: from onset to spread a multicenter italian study.
Authors: Trinchillo, Assunta (AUTHOR), Esposito, Marcello (AUTHOR), Terranova, Carmen (AUTHOR), Rizzo, Vincenzo (AUTHOR), Fabbrini, Giovanni (AUTHOR), Ferrazzano, Gina (AUTHOR), Belvisi, Daniele (AUTHOR), Erro, Roberto (AUTHOR), Barone, Paolo (AUTHOR), Bono, Francesco (AUTHOR), Di Biasio, Francesca (AUTHOR), Bentivoglio, Anna Rita (AUTHOR), Lettieri, Christian (AUTHOR), Altavista, Maria Concetta (AUTHOR), Scaglione, Cesa Lorella Maria (AUTHOR), Albanese, Alberto (AUTHOR), Mascia, Marcello Mario (AUTHOR), Muroni, Antonella (AUTHOR), Pisani, Antonio (AUTHOR), Berardelli, Alfredo (AUTHOR)
Source: Neurological Sciences. Sep2024, Vol. 45 Issue 9, p4341-4348. 8p.
Subjects: Idiopathic diseases, Dystonia, Movement disorders, Regression analysis, Family history (Sociology)
Abstract: Background: Detailed information about the epidemiological and phenomenological differences among the aetiological subtypes of oromandibular dystonia (OMD) is lacking. Moreover, the OMD tendency to spread to other body sites has never been investigated. Aim: To compare the main demographic and clinical features of OMD in different aetiological groups and assess the risk of spread. Materials and methods: We retrospectively analysed data from patients contained in the Italian Dystonia Registry. The risk of spread was assessed by Kaplan Meyer curves and Cox regression analysis. Results: The study included 273 patients (175 women) aged 55.7 years (SD 12.7) at OMD onset. Female predominance was observed. Idiopathic dystonia was diagnosed in 241 patients, acquired dystonia in 22. In 50/273 patients, dystonia started in the oromandibular region (focal OMD onset); in 96/273 patients the onset involved the oromandibular region and a neighbouring body site (segmental/multifocal OMD onset); and in 127/273 patients OMD was a site of spread from another body region. Sensory trick (ST) and positive family history predominated in the idiopathic group. No dystonia spread was detected in the acquired group, whereas spread mostly occurred within the first five years of history in 34% of the focal OMD onset idiopathic patients. Cox regression analysis revealed ST as a significant predictor of spread (HR, 12.1; 95% CI, 2.5 – 18.8; P = 0.002). Conclusion: This large study provides novel information about the clinical phenomenology of idiopathic and acquired OMD. We pointed out a possible role of oestrogens in favouring dystonia development. Moreover, we described for the first time the association between ST and dystonia spread, revealing possible common pathophysiological mechanisms. Our findings may be suggested as a referral point for future pathophysiological and therapeutic studies on OMD. [ABSTRACT FROM AUTHOR]
Copyright of Neurological Sciences is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Oromandibular dystonia: from onset to spread a multicenter italian study.
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  Data: <searchLink fieldCode="DE" term="%22Idiopathic+diseases%22">Idiopathic diseases</searchLink><br /><searchLink fieldCode="DE" term="%22Dystonia%22">Dystonia</searchLink><br /><searchLink fieldCode="DE" term="%22Movement+disorders%22">Movement disorders</searchLink><br /><searchLink fieldCode="DE" term="%22Regression+analysis%22">Regression analysis</searchLink><br /><searchLink fieldCode="DE" term="%22Family+history+%28Sociology%29%22">Family history (Sociology)</searchLink>
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  Label: Abstract
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  Data: Background: Detailed information about the epidemiological and phenomenological differences among the aetiological subtypes of oromandibular dystonia (OMD) is lacking. Moreover, the OMD tendency to spread to other body sites has never been investigated. Aim: To compare the main demographic and clinical features of OMD in different aetiological groups and assess the risk of spread. Materials and methods: We retrospectively analysed data from patients contained in the Italian Dystonia Registry. The risk of spread was assessed by Kaplan Meyer curves and Cox regression analysis. Results: The study included 273 patients (175 women) aged 55.7 years (SD 12.7) at OMD onset. Female predominance was observed. Idiopathic dystonia was diagnosed in 241 patients, acquired dystonia in 22. In 50/273 patients, dystonia started in the oromandibular region (focal OMD onset); in 96/273 patients the onset involved the oromandibular region and a neighbouring body site (segmental/multifocal OMD onset); and in 127/273 patients OMD was a site of spread from another body region. Sensory trick (ST) and positive family history predominated in the idiopathic group. No dystonia spread was detected in the acquired group, whereas spread mostly occurred within the first five years of history in 34% of the focal OMD onset idiopathic patients. Cox regression analysis revealed ST as a significant predictor of spread (HR, 12.1; 95% CI, 2.5 – 18.8; P = 0.002). Conclusion: This large study provides novel information about the clinical phenomenology of idiopathic and acquired OMD. We pointed out a possible role of oestrogens in favouring dystonia development. Moreover, we described for the first time the association between ST and dystonia spread, revealing possible common pathophysiological mechanisms. Our findings may be suggested as a referral point for future pathophysiological and therapeutic studies on OMD. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Neurological Sciences is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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