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A cross-sectional study of multidimensional fatigue in biologic-treated rheumatoid arthritis: which variables play a role?

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Title: A cross-sectional study of multidimensional fatigue in biologic-treated rheumatoid arthritis: which variables play a role?
Authors: Husivargova, Alexandra, Timkova, Vladimira, Macejova, Zelmira, Kotradyova, Zuzana, Sanderman, Robbert, Fleer, Joke, Nagyova, Iveta
Source: Disability & Rehabilitation. Aug2024, Vol. 46 Issue 17, p3878-3886. 9p.
Subjects: Cross-sectional method, Statistical correlation, Research funding, Rheumatoid arthritis, Fatigue (Physiology), Multiple regression analysis, Antirheumatic agents, Biological products, Severity of illness index, Descriptive statistics, Anxiety, Mental fatigue, Pain, Research, Sleep quality, Sociodemographic factors, Data analysis software, Well-being, Mental depression
Abstract: Purpose: Despite efficient biological disease-modifying antirheumatic drugs (bDMARDs) Rheumatoid Arthritis (RA) patients still suffer from high fatigue. This study aims to further our knowledge by assessing severity levels of the various fatigue dimensions and their associations with pain, sleep quality, and psychological well-being in bDMARDs treated RA patients. Material and Methods: The sample consisted of 146 RA patients (84.9% females; mean age 56.6 ± 13.6 years), who completed the MFI-20, SF-36, PSQI, GAD-7 and PHQ-9. Correlation analyses and multiple linear regressions were used to analyse the data. Results: General fatigue was the highest reported type of fatigue, followed by physical fatigue dimensions. In the final regression model, pain and disability were significantly associated with physical fatigue (p ≤ 0.001, p ≤ 0.05, respectively) and reduced activity (p ≤ 0.01, p ≤ 0.05, respectively). Anxiety was significantly associated with mental fatigue (p ≤ 0.05) and reduced motivation (p ≤ 0.01). Regression analyses showed no significant associations between depression, sleep quality, and fatigue in any of the final models. Conclusions: Our findings indicate that effectively addressing fatigue in RA patients requires an individualized approach. This approach should acknowledge the varying degrees of fatigue across different fatigue dimensions (physical or mental), while also taking into account the patient's mental health problems, pain levels, and disability levels. IMPLICATIONS FOR REHABILITATION: despite the high prevalence of fatigue in rheumatoid arthritis (RA), the patients reported that 79% of healthcare professionals do not assess fatigue during visits; therefore, a measure of fatigue should be a part of routine medical examinations rehabilitation professionals should evaluate multidimensional fatigue, which seems to be more informative than a single measure of severity development and use of an effective individual non-pharmacological management program, based on an understanding of the variables associated with multidimensional fatigue may help in improving the quality of life of patients with RA [ABSTRACT FROM AUTHOR]
Copyright of Disability & Rehabilitation is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: A cross-sectional study of multidimensional fatigue in biologic-treated rheumatoid arthritis: which variables play a role?
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  Data: <searchLink fieldCode="AR" term="%22Husivargova%2C+Alexandra%22">Husivargova, Alexandra</searchLink><br /><searchLink fieldCode="AR" term="%22Timkova%2C+Vladimira%22">Timkova, Vladimira</searchLink><br /><searchLink fieldCode="AR" term="%22Macejova%2C+Zelmira%22">Macejova, Zelmira</searchLink><br /><searchLink fieldCode="AR" term="%22Kotradyova%2C+Zuzana%22">Kotradyova, Zuzana</searchLink><br /><searchLink fieldCode="AR" term="%22Sanderman%2C+Robbert%22">Sanderman, Robbert</searchLink><br /><searchLink fieldCode="AR" term="%22Fleer%2C+Joke%22">Fleer, Joke</searchLink><br /><searchLink fieldCode="AR" term="%22Nagyova%2C+Iveta%22">Nagyova, Iveta</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22Disability+%26+Rehabilitation%22">Disability & Rehabilitation</searchLink>. Aug2024, Vol. 46 Issue 17, p3878-3886. 9p.
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– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Purpose: Despite efficient biological disease-modifying antirheumatic drugs (bDMARDs) Rheumatoid Arthritis (RA) patients still suffer from high fatigue. This study aims to further our knowledge by assessing severity levels of the various fatigue dimensions and their associations with pain, sleep quality, and psychological well-being in bDMARDs treated RA patients. Material and Methods: The sample consisted of 146 RA patients (84.9% females; mean age 56.6 ± 13.6 years), who completed the MFI-20, SF-36, PSQI, GAD-7 and PHQ-9. Correlation analyses and multiple linear regressions were used to analyse the data. Results: General fatigue was the highest reported type of fatigue, followed by physical fatigue dimensions. In the final regression model, pain and disability were significantly associated with physical fatigue (p ≤ 0.001, p ≤ 0.05, respectively) and reduced activity (p ≤ 0.01, p ≤ 0.05, respectively). Anxiety was significantly associated with mental fatigue (p ≤ 0.05) and reduced motivation (p ≤ 0.01). Regression analyses showed no significant associations between depression, sleep quality, and fatigue in any of the final models. Conclusions: Our findings indicate that effectively addressing fatigue in RA patients requires an individualized approach. This approach should acknowledge the varying degrees of fatigue across different fatigue dimensions (physical or mental), while also taking into account the patient's mental health problems, pain levels, and disability levels. IMPLICATIONS FOR REHABILITATION: despite the high prevalence of fatigue in rheumatoid arthritis (RA), the patients reported that 79% of healthcare professionals do not assess fatigue during visits; therefore, a measure of fatigue should be a part of routine medical examinations rehabilitation professionals should evaluate multidimensional fatigue, which seems to be more informative than a single measure of severity development and use of an effective individual non-pharmacological management program, based on an understanding of the variables associated with multidimensional fatigue may help in improving the quality of life of patients with RA [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
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  Data: <i>Copyright of Disability & Rehabilitation is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=179022981
RecordInfo BibRecord:
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    Identifiers:
      – Type: doi
        Value: 10.1080/09638288.2023.2258333
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      – Code: eng
        Text: English
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        PageCount: 9
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      – SubjectFull: Cross-sectional method
        Type: general
      – SubjectFull: Statistical correlation
        Type: general
      – SubjectFull: Research funding
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      – SubjectFull: Rheumatoid arthritis
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      – SubjectFull: Fatigue (Physiology)
        Type: general
      – SubjectFull: Multiple regression analysis
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      – SubjectFull: Antirheumatic agents
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      – SubjectFull: Biological products
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      – SubjectFull: Anxiety
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      – TitleFull: A cross-sectional study of multidimensional fatigue in biologic-treated rheumatoid arthritis: which variables play a role?
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              Text: Aug2024
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