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Chemerin in caudal division of nucleus tractus solitarius increases sympathetic activity and blood pressure.

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Title: Chemerin in caudal division of nucleus tractus solitarius increases sympathetic activity and blood pressure.
Authors: Hao, Wen‐Yuan (AUTHOR), Wang, Jing‐Xiao (AUTHOR), Xu, Xiao‐Yu (AUTHOR), Chen, Jun‐Liu (AUTHOR), Chen, Qi (AUTHOR), Li, Yue‐Hua (AUTHOR), Zhu, Guo‐Qing (AUTHOR), Chen, Ai‐Dong (AUTHOR)
Source: European Journal of Neuroscience. Sep2024, Vol. 60 Issue 5, p4830-4842. 13p.
Subjects: Nicotinamide adenine dinucleotide phosphate, Solitary nucleus, Chemerin, NADPH oxidase, Paraventricular nucleus, Blood pressure, Superoxides
Abstract: Chemerin is an adipokine that contributes to metabolism regulation. Nucleus tractus solitarius (NTS) is the first relay station in the brain for accepting various visceral afferent activities for regulating cardiovascular activity. However, the roles of chemerin in the NTS in regulating sympathetic activity and blood pressure are almost unknown. This study aimed to determine the role and potential mechanism of chemerin in the NTS in modulating sympathetic outflow and blood pressure. Bilateral NTS microinjections were performed in anaesthetized adult male Sprague–Dawley rats. Renal sympathetic nerve activity (RSNA), mean arterial pressure (MAP) and heart rate (HR) were continuously recorded. Chemerin and its receptor chemokine‐like receptor 1 (CMKLR1) were highly expressed in caudal NTS (cNTS). Microinjection of chemerin‐9 to the cNTS increased RSNA, MAP and HR, which were prevented by CMKLR1 antagonist α‐NETA, superoxide scavenger tempol or N‐acetyl cysteine, nicotinamide adenine dinucleotide phosphate (NADPH) oxidase inhibitors diphenyleneiodonium or apocynin. Chemerin‐9 increased superoxide production and NADPH oxidase activity in the cNTS. The increased superoxide production induced by chemerin‐9 was inhibited by α‐NETA. The effects of cNTS microinjection of chemerin‐9 on the RSNA, MAP and HR were attenuated by the pretreatment with paraventricular nucleus (PVN) microinjection of NMDA receptor antagonist MK‐801 rather than AMPA/kainate receptor antagonist CNQX. These results indicate that chemerin‐9 in the NTS increases sympathetic outflow, blood pressure and HR via CMKLR1‐mediated NADPH oxidase activation and subsequent superoxide production in anaesthetized normotensive rats. Glutamatergic inputs in the PVN are needed for the chemerin‐9‐induced responses. [ABSTRACT FROM AUTHOR]
Copyright of European Journal of Neuroscience is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Label: Title
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  Data: Chemerin in caudal division of nucleus tractus solitarius increases sympathetic activity and blood pressure.
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  Data: <searchLink fieldCode="AR" term="%22Hao%2C+Wen‐Yuan%22">Hao, Wen‐Yuan</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Wang%2C+Jing‐Xiao%22">Wang, Jing‐Xiao</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Xu%2C+Xiao‐Yu%22">Xu, Xiao‐Yu</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Chen%2C+Jun‐Liu%22">Chen, Jun‐Liu</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Chen%2C+Qi%22">Chen, Qi</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Li%2C+Yue‐Hua%22">Li, Yue‐Hua</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zhu%2C+Guo‐Qing%22">Zhu, Guo‐Qing</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Chen%2C+Ai‐Dong%22">Chen, Ai‐Dong</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22European+Journal+of+Neuroscience%22">European Journal of Neuroscience</searchLink>. Sep2024, Vol. 60 Issue 5, p4830-4842. 13p.
– Name: Subject
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  Data: <searchLink fieldCode="DE" term="%22Nicotinamide+adenine+dinucleotide+phosphate%22">Nicotinamide adenine dinucleotide phosphate</searchLink><br /><searchLink fieldCode="DE" term="%22Solitary+nucleus%22">Solitary nucleus</searchLink><br /><searchLink fieldCode="DE" term="%22Chemerin%22">Chemerin</searchLink><br /><searchLink fieldCode="DE" term="%22NADPH+oxidase%22">NADPH oxidase</searchLink><br /><searchLink fieldCode="DE" term="%22Paraventricular+nucleus%22">Paraventricular nucleus</searchLink><br /><searchLink fieldCode="DE" term="%22Blood+pressure%22">Blood pressure</searchLink><br /><searchLink fieldCode="DE" term="%22Superoxides%22">Superoxides</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Chemerin is an adipokine that contributes to metabolism regulation. Nucleus tractus solitarius (NTS) is the first relay station in the brain for accepting various visceral afferent activities for regulating cardiovascular activity. However, the roles of chemerin in the NTS in regulating sympathetic activity and blood pressure are almost unknown. This study aimed to determine the role and potential mechanism of chemerin in the NTS in modulating sympathetic outflow and blood pressure. Bilateral NTS microinjections were performed in anaesthetized adult male Sprague–Dawley rats. Renal sympathetic nerve activity (RSNA), mean arterial pressure (MAP) and heart rate (HR) were continuously recorded. Chemerin and its receptor chemokine‐like receptor 1 (CMKLR1) were highly expressed in caudal NTS (cNTS). Microinjection of chemerin‐9 to the cNTS increased RSNA, MAP and HR, which were prevented by CMKLR1 antagonist α‐NETA, superoxide scavenger tempol or N‐acetyl cysteine, nicotinamide adenine dinucleotide phosphate (NADPH) oxidase inhibitors diphenyleneiodonium or apocynin. Chemerin‐9 increased superoxide production and NADPH oxidase activity in the cNTS. The increased superoxide production induced by chemerin‐9 was inhibited by α‐NETA. The effects of cNTS microinjection of chemerin‐9 on the RSNA, MAP and HR were attenuated by the pretreatment with paraventricular nucleus (PVN) microinjection of NMDA receptor antagonist MK‐801 rather than AMPA/kainate receptor antagonist CNQX. These results indicate that chemerin‐9 in the NTS increases sympathetic outflow, blood pressure and HR via CMKLR1‐mediated NADPH oxidase activation and subsequent superoxide production in anaesthetized normotensive rats. Glutamatergic inputs in the PVN are needed for the chemerin‐9‐induced responses. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of European Journal of Neuroscience is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=179411723
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      – Type: doi
        Value: 10.1111/ejn.16475
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 13
        StartPage: 4830
    Subjects:
      – SubjectFull: Nicotinamide adenine dinucleotide phosphate
        Type: general
      – SubjectFull: Solitary nucleus
        Type: general
      – SubjectFull: Chemerin
        Type: general
      – SubjectFull: NADPH oxidase
        Type: general
      – SubjectFull: Paraventricular nucleus
        Type: general
      – SubjectFull: Blood pressure
        Type: general
      – SubjectFull: Superoxides
        Type: general
    Titles:
      – TitleFull: Chemerin in caudal division of nucleus tractus solitarius increases sympathetic activity and blood pressure.
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            NameFull: Hao, Wen‐Yuan
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            – D: 01
              M: 09
              Text: Sep2024
              Type: published
              Y: 2024
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