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Safety of craniotomy for brain tumor resection in octogenarians and older patients – a matched - cohort analysis.

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Title: Safety of craniotomy for brain tumor resection in octogenarians and older patients – a matched - cohort analysis.
Authors: Santiago, Raphael Augusto Corrêa Bastianon (AUTHOR), Ali, Assad (AUTHOR), Ibrahim, Bilal (AUTHOR), Mandel, Mauricio (AUTHOR), Muhsen, Baha'eddin A. (AUTHOR), Obrzut, Michal (AUTHOR), Ranjan, Surabhi (AUTHOR), Borghei-Razavi, Hamid (AUTHOR), Adada, Badih (AUTHOR)
Source: International Journal of Neuroscience. Sep2024, Vol. 134 Issue 9, p958-964. 7p.
Subjects: Older people, Octogenarians, Older patients, Surgical complications, Prognosis
Abstract: Introduction: The incidence of brain tumors has increased in elderly population overtime. Their eligibility to a major surgery remains a questionable subject. This study evaluated prognostic factors and 30-days morbidity and mortality in octogenarian population who underwent craniotomy for resection of brain tumor. Materials and methods: A total of 154 patients were divided into two different groups: patients above 80 years old and patients below 65 years old. In both groups, patients were stratified based on diagnosis with benign tumors [meningioma] and malignant tumors [high-grade gliomas and metastases]. Multivariable logistic regression model with backward elimination method was utilized to identify the independent risk factors for 30-days readmission and post-operative complications. Results: The analysis revealed no significant difference in 30-day readmission (p = 0.7329), 30-day mortality (0.6854) or in post-operative complication (p = 0.3291) between age ≥ 80 and age ≤ 65 groups. A longer length of stay (LOS) was observed in the older patients (p = 0.0479). There was a significant difference in the pre-post KPS between the two groups (p < 0.0001). ASA (p = 0.0315) and KPS (p = 0.071) were found as important prognostic factors associated with post-operative mortality in both groups. Conclusion: Octogenarians can withstand craniotomy without any significant increase in 30-day readmission, 30-day mortality and post-operative complications as compared to patients younger than age 65. The ASA score (>3) and/or KPS (<70) were the most important prognostic factors for 30-days readmission and mortality. [ABSTRACT FROM AUTHOR]
Copyright of International Journal of Neuroscience is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Safety of craniotomy for brain tumor resection in octogenarians and older patients – a matched - cohort analysis.
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  Data: &lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Santiago%2C+Raphael+Augusto+Corr&#234;a+Bastianon%22&quot;&gt;Santiago, Raphael Augusto Corr&#234;a Bastianon&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Ali%2C+Assad%22&quot;&gt;Ali, Assad&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Ibrahim%2C+Bilal%22&quot;&gt;Ibrahim, Bilal&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Mandel%2C+Mauricio%22&quot;&gt;Mandel, Mauricio&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Muhsen%2C+Baha&#39;eddin+A%2E%22&quot;&gt;Muhsen, Baha&#39;eddin A.&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Obrzut%2C+Michal%22&quot;&gt;Obrzut, Michal&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Ranjan%2C+Surabhi%22&quot;&gt;Ranjan, Surabhi&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Borghei-Razavi%2C+Hamid%22&quot;&gt;Borghei-Razavi, Hamid&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Adada%2C+Badih%22&quot;&gt;Adada, Badih&lt;/searchLink&gt; (AUTHOR)
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  Data: &lt;searchLink fieldCode=&quot;JN&quot; term=&quot;%22International+Journal+of+Neuroscience%22&quot;&gt;International Journal of Neuroscience&lt;/searchLink&gt;. Sep2024, Vol. 134 Issue 9, p958-964. 7p.
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  Data: &lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Older+people%22&quot;&gt;Older people&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Octogenarians%22&quot;&gt;Octogenarians&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Older+patients%22&quot;&gt;Older patients&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Surgical+complications%22&quot;&gt;Surgical complications&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Prognosis%22&quot;&gt;Prognosis&lt;/searchLink&gt;
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Introduction: The incidence of brain tumors has increased in elderly population overtime. Their eligibility to a major surgery remains a questionable subject. This study evaluated prognostic factors and 30-days morbidity and mortality in octogenarian population who underwent craniotomy for resection of brain tumor. Materials and methods: A total of 154 patients were divided into two different groups: patients above 80 years old and patients below 65 years old. In both groups, patients were stratified based on diagnosis with benign tumors [meningioma] and malignant tumors [high-grade gliomas and metastases]. Multivariable logistic regression model with backward elimination method was utilized to identify the independent risk factors for 30-days readmission and post-operative complications. Results: The analysis revealed no significant difference in 30-day readmission (p = 0.7329), 30-day mortality (0.6854) or in post-operative complication (p = 0.3291) between age ≥ 80 and age ≤ 65 groups. A longer length of stay (LOS) was observed in the older patients (p = 0.0479). There was a significant difference in the pre-post KPS between the two groups (p &lt; 0.0001). ASA (p = 0.0315) and KPS (p = 0.071) were found as important prognostic factors associated with post-operative mortality in both groups. Conclusion: Octogenarians can withstand craniotomy without any significant increase in 30-day readmission, 30-day mortality and post-operative complications as compared to patients younger than age 65. The ASA score (&gt;3) and/or KPS (&lt;70) were the most important prognostic factors for 30-days readmission and mortality. [ABSTRACT FROM AUTHOR]
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  Data: &lt;i&gt;Copyright of International Journal of Neuroscience is the property of Taylor &amp; Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder&#39;s express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.&lt;/i&gt; (Copyright applies to all Abstracts.)
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      – Type: doi
        Value: 10.1080/00207454.2023.2174866
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      – Code: eng
        Text: English
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        PageCount: 7
        StartPage: 958
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      – SubjectFull: Older people
        Type: general
      – SubjectFull: Octogenarians
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      – SubjectFull: Older patients
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      – SubjectFull: Surgical complications
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      – SubjectFull: Prognosis
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              Text: Sep2024
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