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Vibro-tactile stimulation of the neck reduces pain in people with cervical dystonia: a proof-of-concept study.

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Title: Vibro-tactile stimulation of the neck reduces pain in people with cervical dystonia: a proof-of-concept study.
Authors: Xu, Jiapeng (AUTHOR), Costanzo, Matteo (AUTHOR), Avanzino, Laura (AUTHOR), Martino, Davide (AUTHOR), Salehi, Parisa (AUTHOR), Standal, Stephanie (AUTHOR), Manzo, Nicoletta (AUTHOR), Alizadeh, Parisa (AUTHOR), Terranova, Sara (AUTHOR), Bonassi, Gaia (AUTHOR), Oh, Jinseok (AUTHOR), Conte, Antonella (AUTHOR), Konczak, Jürgen (AUTHOR)
Source: Neurological Sciences. Oct2024, Vol. 45 Issue 10, p4847-4856. 10p.
Subjects: Focal dystonia, Trapezius muscle, Pain management, Biomarkers, Proof of concept, Neck pain
Abstract: Background: Pain is a common non-motor symptom in patients with cervical dystonia (CD), severely impacting their quality of life. The pathophysiology of CD is incompletely understood but it involves altered processing of proprioceptive and pain signals. Objectives: The purpose of this proof-of-concept study was to determine if vibro-tactile stimulation (VTS)—a non-invasive form of neuromodulation targeting the somatosensory system—can modulate neck pain in people with CD. Methods: In a multi-center study, 44 CD patients received VTS to sternocleidomastoid and/or trapezius muscles for up to 45 min under 9 different stimulation conditions that either targeted a single or a pair of muscles. The primary outcome measure was a perceived pain score (PPS) rated by participants on a 100-point analogue scale. Results: During VTS, 29/44 (66%) of participants experienced a reduction in PPS of at least 10% with 17/44 (39%) reporting a reduction in pain of 50% or higher. After VTS cessation, 57% of participants still reported a 10% or higher reduction in PPS. Effects were significant at the group level and persisted for up to 20 min post-treatment. No distinct optimal stimulation profiles were identified for specific CD phenotypes. Clinical markers of disease severity or duration did not predict the degree of VTS-induced pain reduction. Conclusion: This proof-of-concept study demonstrates the potential of VTS as a new non-invasive therapeutic option for treating neck pain associated with CD. Further research needs to delineate optimal dosage and long-term effects. [ABSTRACT FROM AUTHOR]
Copyright of Neurological Sciences is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Vibro-tactile stimulation of the neck reduces pain in people with cervical dystonia: a proof-of-concept study.
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  Data: <searchLink fieldCode="AR" term="%22Xu%2C+Jiapeng%22">Xu, Jiapeng</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Costanzo%2C+Matteo%22">Costanzo, Matteo</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Avanzino%2C+Laura%22">Avanzino, Laura</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Martino%2C+Davide%22">Martino, Davide</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Salehi%2C+Parisa%22">Salehi, Parisa</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Standal%2C+Stephanie%22">Standal, Stephanie</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Manzo%2C+Nicoletta%22">Manzo, Nicoletta</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Alizadeh%2C+Parisa%22">Alizadeh, Parisa</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Terranova%2C+Sara%22">Terranova, Sara</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Bonassi%2C+Gaia%22">Bonassi, Gaia</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Oh%2C+Jinseok%22">Oh, Jinseok</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Conte%2C+Antonella%22">Conte, Antonella</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Konczak%2C+Jürgen%22">Konczak, Jürgen</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Neurological+Sciences%22">Neurological Sciences</searchLink>. Oct2024, Vol. 45 Issue 10, p4847-4856. 10p.
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  Data: <searchLink fieldCode="DE" term="%22Focal+dystonia%22">Focal dystonia</searchLink><br /><searchLink fieldCode="DE" term="%22Trapezius+muscle%22">Trapezius muscle</searchLink><br /><searchLink fieldCode="DE" term="%22Pain+management%22">Pain management</searchLink><br /><searchLink fieldCode="DE" term="%22Biomarkers%22">Biomarkers</searchLink><br /><searchLink fieldCode="DE" term="%22Proof+of+concept%22">Proof of concept</searchLink><br /><searchLink fieldCode="DE" term="%22Neck+pain%22">Neck pain</searchLink>
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  Data: Background: Pain is a common non-motor symptom in patients with cervical dystonia (CD), severely impacting their quality of life. The pathophysiology of CD is incompletely understood but it involves altered processing of proprioceptive and pain signals. Objectives: The purpose of this proof-of-concept study was to determine if vibro-tactile stimulation (VTS)—a non-invasive form of neuromodulation targeting the somatosensory system—can modulate neck pain in people with CD. Methods: In a multi-center study, 44 CD patients received VTS to sternocleidomastoid and/or trapezius muscles for up to 45 min under 9 different stimulation conditions that either targeted a single or a pair of muscles. The primary outcome measure was a perceived pain score (PPS) rated by participants on a 100-point analogue scale. Results: During VTS, 29/44 (66%) of participants experienced a reduction in PPS of at least 10% with 17/44 (39%) reporting a reduction in pain of 50% or higher. After VTS cessation, 57% of participants still reported a 10% or higher reduction in PPS. Effects were significant at the group level and persisted for up to 20 min post-treatment. No distinct optimal stimulation profiles were identified for specific CD phenotypes. Clinical markers of disease severity or duration did not predict the degree of VTS-induced pain reduction. Conclusion: This proof-of-concept study demonstrates the potential of VTS as a new non-invasive therapeutic option for treating neck pain associated with CD. Further research needs to delineate optimal dosage and long-term effects. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Neurological Sciences is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Text: English
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        Type: general
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