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Forgetting rate for the familiarity and recollection components of recognition in amnestic mild cognitive impairment: A longitudinal study.

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Title: Forgetting rate for the familiarity and recollection components of recognition in amnestic mild cognitive impairment: A longitudinal study.
Authors: De Simone, Maria Stefania (AUTHOR), Lombardi, Maria Giovanna (AUTHOR), De Tollis, Massimo (AUTHOR), Perri, Roberta (AUTHOR), Fadda, Lucia (AUTHOR), Caltagirone, Carlo (AUTHOR), Carlesimo, Giovanni Augusto (AUTHOR)
Source: Applied Neuropsychology: Adult. Nov/Dec2024, Vol. 31 Issue 6, p1411-1423. 13p.
Subjects: Recollection (Psychology), Recognition (Psychology), Amnestic mild cognitive impairment, Explicit memory, Alzheimer's disease
Abstract: Here we aimed to investigate the rate of forgetting of the familiarity and recollection components of recognition in patients at the onset of medial temporal lobe (MTL) pathology and destined to convert to Alzheimer's disease (AD). For this purpose, we conducted a longitudinal study of 13 patients who were diagnosed with amnestic mild cognitive impairment (a-MCI) at the first assessment and followed-up for 3 years. During this time, five patients converted to AD and eight remained in a stable condition of cognitive impairment. A group of 15 healthy subjects were enrolled as the control group (HC). In order to separately quantify the contribution of recollection and familiarity to recognition memory performance, the experimental sample was submitted to a modified version of Huppert and Piercy's procedure that included a Remember/Know paradigm. Data demonstrated that both stable and converter a-MCI patients forgot memory traces relative to the familiarity components of recognition at the same rate as HC. Conversely, converter a-MCI patients showed accelerated long-term forgetting specifically for the recollection component of recognition compared to stable a-MCI and HC. This is the first empirical demonstration that familiarity and recollection components of declarative memory are subject to different rates of forgetting in a-MCI patients as a function of their longitudinal clinical outcome. Our finding of accelerated long-term forgetting of the recollection component of recognition disclosed by converter a-MCI patients suggests that atrophy in the MTL not only interferes with the storage aspects but also disrupts the consolidation of memory traces. [ABSTRACT FROM AUTHOR]
Copyright of Applied Neuropsychology: Adult is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Forgetting rate for the familiarity and recollection components of recognition in amnestic mild cognitive impairment: A longitudinal study.
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  Data: <searchLink fieldCode="AR" term="%22De+Simone%2C+Maria+Stefania%22">De Simone, Maria Stefania</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lombardi%2C+Maria+Giovanna%22">Lombardi, Maria Giovanna</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22De+Tollis%2C+Massimo%22">De Tollis, Massimo</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Perri%2C+Roberta%22">Perri, Roberta</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Fadda%2C+Lucia%22">Fadda, Lucia</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Caltagirone%2C+Carlo%22">Caltagirone, Carlo</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Carlesimo%2C+Giovanni+Augusto%22">Carlesimo, Giovanni Augusto</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Applied+Neuropsychology%3A+Adult%22">Applied Neuropsychology: Adult</searchLink>. Nov/Dec2024, Vol. 31 Issue 6, p1411-1423. 13p.
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  Data: <searchLink fieldCode="DE" term="%22Recollection+%28Psychology%29%22">Recollection (Psychology)</searchLink><br /><searchLink fieldCode="DE" term="%22Recognition+%28Psychology%29%22">Recognition (Psychology)</searchLink><br /><searchLink fieldCode="DE" term="%22Amnestic+mild+cognitive+impairment%22">Amnestic mild cognitive impairment</searchLink><br /><searchLink fieldCode="DE" term="%22Explicit+memory%22">Explicit memory</searchLink><br /><searchLink fieldCode="DE" term="%22Alzheimer's+disease%22">Alzheimer's disease</searchLink>
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  Data: Here we aimed to investigate the rate of forgetting of the familiarity and recollection components of recognition in patients at the onset of medial temporal lobe (MTL) pathology and destined to convert to Alzheimer's disease (AD). For this purpose, we conducted a longitudinal study of 13 patients who were diagnosed with amnestic mild cognitive impairment (a-MCI) at the first assessment and followed-up for 3 years. During this time, five patients converted to AD and eight remained in a stable condition of cognitive impairment. A group of 15 healthy subjects were enrolled as the control group (HC). In order to separately quantify the contribution of recollection and familiarity to recognition memory performance, the experimental sample was submitted to a modified version of Huppert and Piercy's procedure that included a Remember/Know paradigm. Data demonstrated that both stable and converter a-MCI patients forgot memory traces relative to the familiarity components of recognition at the same rate as HC. Conversely, converter a-MCI patients showed accelerated long-term forgetting specifically for the recollection component of recognition compared to stable a-MCI and HC. This is the first empirical demonstration that familiarity and recollection components of declarative memory are subject to different rates of forgetting in a-MCI patients as a function of their longitudinal clinical outcome. Our finding of accelerated long-term forgetting of the recollection component of recognition disclosed by converter a-MCI patients suggests that atrophy in the MTL not only interferes with the storage aspects but also disrupts the consolidation of memory traces. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Applied Neuropsychology: Adult is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1080/23279095.2022.2135441
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        Text: English
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              Text: Nov/Dec2024
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              Y: 2024
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