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Cerebellar cognitive affective syndrome with long-term features of autism spectrum disorder: evidence in a 9-year-old girl after vermian medulloblastoma surgery.

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Title: Cerebellar cognitive affective syndrome with long-term features of autism spectrum disorder: evidence in a 9-year-old girl after vermian medulloblastoma surgery.
Authors: Taddei, Matilde (AUTHOR), Bulgheroni, Sara (AUTHOR), Erbetta, Alessandra (AUTHOR), Faccio, Flavia (AUTHOR), Giorgi, Cesare (AUTHOR), Riva, Daria (AUTHOR)
Source: Child Neuropsychology. Oct2024, Vol. 30 Issue 7, p1116-1124. 9p.
Subjects: Infratentorial brain tumors, Autism spectrum disorders, Social skills, Social perception, Tumor surgery, Children with autism spectrum disorders
Abstract: The time course of socio-communicative disturbances in children after posterior fossa tumor resection is variable in clinical reports, and its assessment may help to understand the role of the cerebellum in the pathogenesis of socio-communicative disorders and improve rehabilitation plans. We report the 3-year cognitive-behavioral follow-up of a female patient (LZ) who underwent surgical ablation of the vermis due to medulloblastoma at age 9. LZ developed a severe post-operative Cerebellar Cognitive Affective Syndrome (CCAS) with cognitive-executive dysfunctions and behavioral alterations resembling an Autism Spectrum Disorder (ASD)-like syndrome. The lack of empathy and reduced ability to recognize others' intentions and mental states persisted at follow-up evaluations, as did language alterations. The present case report evidenced that lesions affecting cerebellar and vermal lobules may cause severe CCAS and impairment of social skills overlapping with that observed in ASD. This case is significant in its clinical features, revealing long-term social impairment, while the cognitive, linguistic, and executive functioning improved over time. Prospective case studies should plan the evaluation of symptoms of ASD within the clinical longitudinal assessment. [ABSTRACT FROM AUTHOR]
Copyright of Child Neuropsychology is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Cerebellar cognitive affective syndrome with long-term features of autism spectrum disorder: evidence in a 9-year-old girl after vermian medulloblastoma surgery.
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  Data: <searchLink fieldCode="AR" term="%22Taddei%2C+Matilde%22">Taddei, Matilde</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Bulgheroni%2C+Sara%22">Bulgheroni, Sara</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Erbetta%2C+Alessandra%22">Erbetta, Alessandra</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Faccio%2C+Flavia%22">Faccio, Flavia</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Giorgi%2C+Cesare%22">Giorgi, Cesare</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Riva%2C+Daria%22">Riva, Daria</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Child+Neuropsychology%22">Child Neuropsychology</searchLink>. Oct2024, Vol. 30 Issue 7, p1116-1124. 9p.
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  Data: <searchLink fieldCode="DE" term="%22Infratentorial+brain+tumors%22">Infratentorial brain tumors</searchLink><br /><searchLink fieldCode="DE" term="%22Autism+spectrum+disorders%22">Autism spectrum disorders</searchLink><br /><searchLink fieldCode="DE" term="%22Social+skills%22">Social skills</searchLink><br /><searchLink fieldCode="DE" term="%22Social+perception%22">Social perception</searchLink><br /><searchLink fieldCode="DE" term="%22Tumor+surgery%22">Tumor surgery</searchLink><br /><searchLink fieldCode="DE" term="%22Children+with+autism+spectrum+disorders%22">Children with autism spectrum disorders</searchLink>
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  Data: The time course of socio-communicative disturbances in children after posterior fossa tumor resection is variable in clinical reports, and its assessment may help to understand the role of the cerebellum in the pathogenesis of socio-communicative disorders and improve rehabilitation plans. We report the 3-year cognitive-behavioral follow-up of a female patient (LZ) who underwent surgical ablation of the vermis due to medulloblastoma at age 9. LZ developed a severe post-operative Cerebellar Cognitive Affective Syndrome (CCAS) with cognitive-executive dysfunctions and behavioral alterations resembling an Autism Spectrum Disorder (ASD)-like syndrome. The lack of empathy and reduced ability to recognize others' intentions and mental states persisted at follow-up evaluations, as did language alterations. The present case report evidenced that lesions affecting cerebellar and vermal lobules may cause severe CCAS and impairment of social skills overlapping with that observed in ASD. This case is significant in its clinical features, revealing long-term social impairment, while the cognitive, linguistic, and executive functioning improved over time. Prospective case studies should plan the evaluation of symptoms of ASD within the clinical longitudinal assessment. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Child Neuropsychology is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1080/09297049.2024.2302691
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      – SubjectFull: Autism spectrum disorders
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              Text: Oct2024
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