The posterior intralaminar thalamic nucleus promotes nose‐to‐nose contacts leading to prosocial reception in the sequence of mouse social interaction.
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| Title: | The posterior intralaminar thalamic nucleus promotes nose‐to‐nose contacts leading to prosocial reception in the sequence of mouse social interaction. |
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| Authors: | Arakawa, Hiroyuki (AUTHOR), Tokashiki, Mana (AUTHOR) |
| Source: | European Journal of Neuroscience. Oct2024, Vol. 60 Issue 7, p5731-5749. 19p. |
| Subjects: | Paraventricular nucleus, Social interaction, Thalamus, Neurons, Laboratory mice, Thalamic nuclei |
| Abstract: | Efficient social interaction is essential for an adaptive life and consists of sequential processes of multisensory events with social counterparts. Social touch/contact is a unique component that promotes a sequence of social behaviours initiated by detection and approach to assess a social stimulus and subsequent touch/contact interaction to form prosocial relationships. We hypothesized that the thalamic sensory relay circuit from the posterior intralaminar nucleus of the thalamus (pIL) to the paraventricular nucleus of the hypothalamus (PVN) and the medial amygdala (MeA) plays a key role in the social contact‐mediated sequence of events. We found that neurons in the pIL along with the PVN and MeA were activated by social encounters and that pIL activity was more abundant in a direct physical encounter, whereas MeA activity was dominant in an indirect through grid encounter. Chemogenetic inhibition of pIL neurons selectively decreased the investigatory approach and sniffing of a same‐sex, but not an opposite‐sex, stimulus mouse in an indirect encounter situation and decreased the facial/snout contact ratio in a direct encounter setting. Furthermore, chemogenetic pIL inhibition had no impact on anxiety‐like behaviours or body coordinative motor behaviours, but it impaired whisker‐related and plantar touch tactile sense. We propose that the pIL circuit can relay social tactile sensations and mediate the sequence of nonsexual prosocial interactions through an investigatory approach to tactile contact and thus plays a significant role in establishing prosocial relationships in mouse models. [ABSTRACT FROM AUTHOR] |
| Copyright of European Journal of Neuroscience is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 180109255 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: The posterior intralaminar thalamic nucleus promotes nose‐to‐nose contacts leading to prosocial reception in the sequence of mouse social interaction. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Arakawa%2C+Hiroyuki%22">Arakawa, Hiroyuki</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Tokashiki%2C+Mana%22">Tokashiki, Mana</searchLink> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22European+Journal+of+Neuroscience%22">European Journal of Neuroscience</searchLink>. Oct2024, Vol. 60 Issue 7, p5731-5749. 19p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Paraventricular+nucleus%22">Paraventricular nucleus</searchLink><br /><searchLink fieldCode="DE" term="%22Social+interaction%22">Social interaction</searchLink><br /><searchLink fieldCode="DE" term="%22Thalamus%22">Thalamus</searchLink><br /><searchLink fieldCode="DE" term="%22Neurons%22">Neurons</searchLink><br /><searchLink fieldCode="DE" term="%22Laboratory+mice%22">Laboratory mice</searchLink><br /><searchLink fieldCode="DE" term="%22Thalamic+nuclei%22">Thalamic nuclei</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Efficient social interaction is essential for an adaptive life and consists of sequential processes of multisensory events with social counterparts. Social touch/contact is a unique component that promotes a sequence of social behaviours initiated by detection and approach to assess a social stimulus and subsequent touch/contact interaction to form prosocial relationships. We hypothesized that the thalamic sensory relay circuit from the posterior intralaminar nucleus of the thalamus (pIL) to the paraventricular nucleus of the hypothalamus (PVN) and the medial amygdala (MeA) plays a key role in the social contact‐mediated sequence of events. We found that neurons in the pIL along with the PVN and MeA were activated by social encounters and that pIL activity was more abundant in a direct physical encounter, whereas MeA activity was dominant in an indirect through grid encounter. Chemogenetic inhibition of pIL neurons selectively decreased the investigatory approach and sniffing of a same‐sex, but not an opposite‐sex, stimulus mouse in an indirect encounter situation and decreased the facial/snout contact ratio in a direct encounter setting. Furthermore, chemogenetic pIL inhibition had no impact on anxiety‐like behaviours or body coordinative motor behaviours, but it impaired whisker‐related and plantar touch tactile sense. We propose that the pIL circuit can relay social tactile sensations and mediate the sequence of nonsexual prosocial interactions through an investigatory approach to tactile contact and thus plays a significant role in establishing prosocial relationships in mouse models. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of European Journal of Neuroscience is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=180109255 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1111/ejn.16520 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 19 StartPage: 5731 Subjects: – SubjectFull: Paraventricular nucleus Type: general – SubjectFull: Social interaction Type: general – SubjectFull: Thalamus Type: general – SubjectFull: Neurons Type: general – SubjectFull: Laboratory mice Type: general – SubjectFull: Thalamic nuclei Type: general Titles: – TitleFull: The posterior intralaminar thalamic nucleus promotes nose‐to‐nose contacts leading to prosocial reception in the sequence of mouse social interaction. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Arakawa, Hiroyuki – PersonEntity: Name: NameFull: Tokashiki, Mana IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 10 Text: Oct2024 Type: published Y: 2024 Identifiers: – Type: issn-print Value: 0953816X Numbering: – Type: volume Value: 60 – Type: issue Value: 7 Titles: – TitleFull: European Journal of Neuroscience Type: main |
| ResultId | 1 |
