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Intestinal Symptoms Among Children aged 2–7 Years with Autism Spectrum Disorder in 13 Cities of China.

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Title: Intestinal Symptoms Among Children aged 2–7 Years with Autism Spectrum Disorder in 13 Cities of China.
Authors: Yang, Ting, Zhang, Qian, Chen, Li, Dai, Ying, Jia, Fei-Yong, Hao, Yan, Li, Ling, Zhang, Jie, Wu, Li-Jie, Ke, Xiao-Yan, Yi, Ming-Ji, Hong, Qi, Chen, Jin-Jin, Fang, Shuan-Feng, Wang, Yi-Chao, Wang, Qi, Jin, Chun-Hua, Chen, Jie, Li, Ting-Yu
Source: Journal of Autism & Developmental Disorders. Nov2024, Vol. 54 Issue 11, p4302-4310. 9p.
Subjects: Constipation -- Risk factors, Fecal analysis, Asperger's syndrome in children, Risk assessment, Autism in children, Research funding, Questionnaires, Intestinal diseases, Descriptive statistics, Comorbidity, Disease risk factors, Symptoms
Geographic Terms: China
Abstract: Background: Autism spectrum disorder (ASD) is a multifactorial, pervasive, neurodevelopmental disorder, of which intestinal symptoms collectively represent one of the most common comorbidities. Methods: In this study, 1,222 children with ASD and 1,206 typically developing (TD) children aged 2-7 years were enrolled from 13 cities in China. Physical measurement and basic information questionnaires were conducted in ASD and TD children. The Childhood Autism Rating Scale (CARS), Social Responsiveness Scale (SRS), and Autism Behavior Checklist (ABC) were used to evaluate the clinical symptoms of children with ASD. The six-item Gastrointestinal Severity Index (6-GSI) was used to evaluate the prevalence of intestinal symptoms in two groups. Results: The detection rates of constipation, stool odor, and total intestinal symptoms in ASD children were significantly higher than those in TD children (40.098% vs. 25.622%, 17.021% vs. 9.287%, and 53.601% vs. 41.294%, respectively). Autistic children presenting with intestinal comorbidity had significantly higher scores on the ABC, SRS, CARS, and multiple subscales than autistic children without intestinal symptoms, suggesting that intestinal comorbidity may exacerbates the core symptoms of ASD children. Conclusion: Intestinal dysfunction was significantly more common in autistic than in TD children. This dysfunction may aggravate the core symptoms of children with ASD. [ABSTRACT FROM AUTHOR]
Copyright of Journal of Autism & Developmental Disorders is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Intestinal Symptoms Among Children aged 2–7 Years with Autism Spectrum Disorder in 13 Cities of China.
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  Data: <searchLink fieldCode="AR" term="%22Yang%2C+Ting%22">Yang, Ting</searchLink><br /><searchLink fieldCode="AR" term="%22Zhang%2C+Qian%22">Zhang, Qian</searchLink><br /><searchLink fieldCode="AR" term="%22Chen%2C+Li%22">Chen, Li</searchLink><br /><searchLink fieldCode="AR" term="%22Dai%2C+Ying%22">Dai, Ying</searchLink><br /><searchLink fieldCode="AR" term="%22Jia%2C+Fei-Yong%22">Jia, Fei-Yong</searchLink><br /><searchLink fieldCode="AR" term="%22Hao%2C+Yan%22">Hao, Yan</searchLink><br /><searchLink fieldCode="AR" term="%22Li%2C+Ling%22">Li, Ling</searchLink><br /><searchLink fieldCode="AR" term="%22Zhang%2C+Jie%22">Zhang, Jie</searchLink><br /><searchLink fieldCode="AR" term="%22Wu%2C+Li-Jie%22">Wu, Li-Jie</searchLink><br /><searchLink fieldCode="AR" term="%22Ke%2C+Xiao-Yan%22">Ke, Xiao-Yan</searchLink><br /><searchLink fieldCode="AR" term="%22Yi%2C+Ming-Ji%22">Yi, Ming-Ji</searchLink><br /><searchLink fieldCode="AR" term="%22Hong%2C+Qi%22">Hong, Qi</searchLink><br /><searchLink fieldCode="AR" term="%22Chen%2C+Jin-Jin%22">Chen, Jin-Jin</searchLink><br /><searchLink fieldCode="AR" term="%22Fang%2C+Shuan-Feng%22">Fang, Shuan-Feng</searchLink><br /><searchLink fieldCode="AR" term="%22Wang%2C+Yi-Chao%22">Wang, Yi-Chao</searchLink><br /><searchLink fieldCode="AR" term="%22Wang%2C+Qi%22">Wang, Qi</searchLink><br /><searchLink fieldCode="AR" term="%22Jin%2C+Chun-Hua%22">Jin, Chun-Hua</searchLink><br /><searchLink fieldCode="AR" term="%22Chen%2C+Jie%22">Chen, Jie</searchLink><br /><searchLink fieldCode="AR" term="%22Li%2C+Ting-Yu%22">Li, Ting-Yu</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22Journal+of+Autism+%26+Developmental+Disorders%22">Journal of Autism & Developmental Disorders</searchLink>. Nov2024, Vol. 54 Issue 11, p4302-4310. 9p.
– Name: Subject
  Label: Subjects
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  Data: <searchLink fieldCode="DE" term="%22Constipation+--+Risk+factors%22">Constipation -- Risk factors</searchLink><br /><searchLink fieldCode="DE" term="%22Fecal+analysis%22">Fecal analysis</searchLink><br /><searchLink fieldCode="DE" term="%22Asperger's+syndrome+in+children%22">Asperger's syndrome in children</searchLink><br /><searchLink fieldCode="DE" term="%22Risk+assessment%22">Risk assessment</searchLink><br /><searchLink fieldCode="DE" term="%22Autism+in+children%22">Autism in children</searchLink><br /><searchLink fieldCode="DE" term="%22Research+funding%22">Research funding</searchLink><br /><searchLink fieldCode="DE" term="%22Questionnaires%22">Questionnaires</searchLink><br /><searchLink fieldCode="DE" term="%22Intestinal+diseases%22">Intestinal diseases</searchLink><br /><searchLink fieldCode="DE" term="%22Descriptive+statistics%22">Descriptive statistics</searchLink><br /><searchLink fieldCode="DE" term="%22Comorbidity%22">Comorbidity</searchLink><br /><searchLink fieldCode="DE" term="%22Disease+risk+factors%22">Disease risk factors</searchLink><br /><searchLink fieldCode="DE" term="%22Symptoms%22">Symptoms</searchLink>
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  Label: Geographic Terms
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  Data: <searchLink fieldCode="DE" term="%22China%22">China</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Background: Autism spectrum disorder (ASD) is a multifactorial, pervasive, neurodevelopmental disorder, of which intestinal symptoms collectively represent one of the most common comorbidities. Methods: In this study, 1,222 children with ASD and 1,206 typically developing (TD) children aged 2-7 years were enrolled from 13 cities in China. Physical measurement and basic information questionnaires were conducted in ASD and TD children. The Childhood Autism Rating Scale (CARS), Social Responsiveness Scale (SRS), and Autism Behavior Checklist (ABC) were used to evaluate the clinical symptoms of children with ASD. The six-item Gastrointestinal Severity Index (6-GSI) was used to evaluate the prevalence of intestinal symptoms in two groups. Results: The detection rates of constipation, stool odor, and total intestinal symptoms in ASD children were significantly higher than those in TD children (40.098% vs. 25.622%, 17.021% vs. 9.287%, and 53.601% vs. 41.294%, respectively). Autistic children presenting with intestinal comorbidity had significantly higher scores on the ABC, SRS, CARS, and multiple subscales than autistic children without intestinal symptoms, suggesting that intestinal comorbidity may exacerbates the core symptoms of ASD children. Conclusion: Intestinal dysfunction was significantly more common in autistic than in TD children. This dysfunction may aggravate the core symptoms of children with ASD. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Journal of Autism & Developmental Disorders is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
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    Identifiers:
      – Type: doi
        Value: 10.1007/s10803-023-06122-3
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      – Code: eng
        Text: English
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      – SubjectFull: Constipation -- Risk factors
        Type: general
      – SubjectFull: Fecal analysis
        Type: general
      – SubjectFull: Asperger's syndrome in children
        Type: general
      – SubjectFull: Risk assessment
        Type: general
      – SubjectFull: Autism in children
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      – SubjectFull: Research funding
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      – SubjectFull: Questionnaires
        Type: general
      – SubjectFull: Intestinal diseases
        Type: general
      – SubjectFull: Descriptive statistics
        Type: general
      – SubjectFull: Comorbidity
        Type: general
      – SubjectFull: Disease risk factors
        Type: general
      – SubjectFull: Symptoms
        Type: general
      – SubjectFull: China
        Type: general
    Titles:
      – TitleFull: Intestinal Symptoms Among Children aged 2–7 Years with Autism Spectrum Disorder in 13 Cities of China.
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              Text: Nov2024
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