View in EDS HTML Full Text PDF Full Text

Sensory Symptoms and Signs of Hyperarousal in Individuals with Fragile X Syndrome: Findings from the FORWARD Registry and Database Multisite Study.

Saved in:
Bibliographic Details
Title: Sensory Symptoms and Signs of Hyperarousal in Individuals with Fragile X Syndrome: Findings from the FORWARD Registry and Database Multisite Study.
Authors: Lachiewicz, Ave M., Stackhouse, Tracy M., Burgess, Kristin, Burgess, Debra, Andrews, Howard F., Choo, Tse-Hwei, Kaufmann, Walter E., Kidd, Sharon A.
Source: Journal of Autism & Developmental Disorders. Nov2024, Vol. 54 Issue 11, p4259-4277. 19p.
Subjects: Behavior disorders, Social disabilities, Physical therapy, Arousal (Physiology), Research funding, Secondary analysis, Sensorimotor integration, Logistic regression analysis, Fragile X syndrome, Descriptive statistics, Occupational therapy, Regression analysis, Comorbidity, Eye movements, Psychiatric drugs, Symptoms
Abstract: This study was designed to increase our understanding about characteristics and the impact of sensory symptoms (SS) and signs of hyperarousal (HA) in individuals with fragile X syndrome (FXS) from childhood through early adulthood and by gender. Data derived from the Fragile X Online Registry With Accessible Research Database (FORWARD), a natural history study of FXS, were analyzed using descriptive statistics and multivariate linear and logistic regression models to examine SS and signs of HA, their impact on behavioral regulation and limitations on the subject/family. The sample (N = 933) consisted of 720 males and 213 females. More males were affected with SS (87% vs. 68%) and signs of HA (92% vs. 79%). Subjects who were endorsed as having a strong sensory response had more comorbidities, including behavioral problems. The predominant SS was difficulty with eye gaze that increased with age in both genders. As individuals age, there was less use of non-medication therapies, such as occupational therapy (OT)/physical therapy (PT), but there was more use of psychopharmacological medications and investigational drugs for behaviors. Multiple regression models suggested that endorsing SS and signs of HA was associated with statistically significantly increased ABC-C-I subscale scores and limited participation in everyday activities. This study improves our understanding of SS and signs of HA as well as their impact in FXS. It supports the need for more research regarding these clinical symptoms, especially to understand how they contribute to well-known behavioral concerns. [ABSTRACT FROM AUTHOR]
Copyright of Journal of Autism & Developmental Disorders is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
Full text is not displayed to guests.
FullText Links:
  – Type: pdflink
Text:
  Availability: 1
Header DbId: pbh
DbLabel: Psychology and Behavioral Sciences Collection
An: 180153917
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Sensory Symptoms and Signs of Hyperarousal in Individuals with Fragile X Syndrome: Findings from the FORWARD Registry and Database Multisite Study.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Lachiewicz%2C+Ave+M%2E%22">Lachiewicz, Ave M.</searchLink><br /><searchLink fieldCode="AR" term="%22Stackhouse%2C+Tracy+M%2E%22">Stackhouse, Tracy M.</searchLink><br /><searchLink fieldCode="AR" term="%22Burgess%2C+Kristin%22">Burgess, Kristin</searchLink><br /><searchLink fieldCode="AR" term="%22Burgess%2C+Debra%22">Burgess, Debra</searchLink><br /><searchLink fieldCode="AR" term="%22Andrews%2C+Howard+F%2E%22">Andrews, Howard F.</searchLink><br /><searchLink fieldCode="AR" term="%22Choo%2C+Tse-Hwei%22">Choo, Tse-Hwei</searchLink><br /><searchLink fieldCode="AR" term="%22Kaufmann%2C+Walter+E%2E%22">Kaufmann, Walter E.</searchLink><br /><searchLink fieldCode="AR" term="%22Kidd%2C+Sharon+A%2E%22">Kidd, Sharon A.</searchLink>
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22Journal+of+Autism+%26+Developmental+Disorders%22">Journal of Autism & Developmental Disorders</searchLink>. Nov2024, Vol. 54 Issue 11, p4259-4277. 19p.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Behavior+disorders%22">Behavior disorders</searchLink><br /><searchLink fieldCode="DE" term="%22Social+disabilities%22">Social disabilities</searchLink><br /><searchLink fieldCode="DE" term="%22Physical+therapy%22">Physical therapy</searchLink><br /><searchLink fieldCode="DE" term="%22Arousal+%28Physiology%29%22">Arousal (Physiology)</searchLink><br /><searchLink fieldCode="DE" term="%22Research+funding%22">Research funding</searchLink><br /><searchLink fieldCode="DE" term="%22Secondary+analysis%22">Secondary analysis</searchLink><br /><searchLink fieldCode="DE" term="%22Sensorimotor+integration%22">Sensorimotor integration</searchLink><br /><searchLink fieldCode="DE" term="%22Logistic+regression+analysis%22">Logistic regression analysis</searchLink><br /><searchLink fieldCode="DE" term="%22Fragile+X+syndrome%22">Fragile X syndrome</searchLink><br /><searchLink fieldCode="DE" term="%22Descriptive+statistics%22">Descriptive statistics</searchLink><br /><searchLink fieldCode="DE" term="%22Occupational+therapy%22">Occupational therapy</searchLink><br /><searchLink fieldCode="DE" term="%22Regression+analysis%22">Regression analysis</searchLink><br /><searchLink fieldCode="DE" term="%22Comorbidity%22">Comorbidity</searchLink><br /><searchLink fieldCode="DE" term="%22Eye+movements%22">Eye movements</searchLink><br /><searchLink fieldCode="DE" term="%22Psychiatric+drugs%22">Psychiatric drugs</searchLink><br /><searchLink fieldCode="DE" term="%22Symptoms%22">Symptoms</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: This study was designed to increase our understanding about characteristics and the impact of sensory symptoms (SS) and signs of hyperarousal (HA) in individuals with fragile X syndrome (FXS) from childhood through early adulthood and by gender. Data derived from the Fragile X Online Registry With Accessible Research Database (FORWARD), a natural history study of FXS, were analyzed using descriptive statistics and multivariate linear and logistic regression models to examine SS and signs of HA, their impact on behavioral regulation and limitations on the subject/family. The sample (N = 933) consisted of 720 males and 213 females. More males were affected with SS (87% vs. 68%) and signs of HA (92% vs. 79%). Subjects who were endorsed as having a strong sensory response had more comorbidities, including behavioral problems. The predominant SS was difficulty with eye gaze that increased with age in both genders. As individuals age, there was less use of non-medication therapies, such as occupational therapy (OT)/physical therapy (PT), but there was more use of psychopharmacological medications and investigational drugs for behaviors. Multiple regression models suggested that endorsing SS and signs of HA was associated with statistically significantly increased ABC-C-I subscale scores and limited participation in everyday activities. This study improves our understanding of SS and signs of HA as well as their impact in FXS. It supports the need for more research regarding these clinical symptoms, especially to understand how they contribute to well-known behavioral concerns. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Journal of Autism & Developmental Disorders is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=180153917
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1007/s10803-023-06135-y
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 19
        StartPage: 4259
    Subjects:
      – SubjectFull: Behavior disorders
        Type: general
      – SubjectFull: Social disabilities
        Type: general
      – SubjectFull: Physical therapy
        Type: general
      – SubjectFull: Arousal (Physiology)
        Type: general
      – SubjectFull: Research funding
        Type: general
      – SubjectFull: Secondary analysis
        Type: general
      – SubjectFull: Sensorimotor integration
        Type: general
      – SubjectFull: Logistic regression analysis
        Type: general
      – SubjectFull: Fragile X syndrome
        Type: general
      – SubjectFull: Descriptive statistics
        Type: general
      – SubjectFull: Occupational therapy
        Type: general
      – SubjectFull: Regression analysis
        Type: general
      – SubjectFull: Comorbidity
        Type: general
      – SubjectFull: Eye movements
        Type: general
      – SubjectFull: Psychiatric drugs
        Type: general
      – SubjectFull: Symptoms
        Type: general
    Titles:
      – TitleFull: Sensory Symptoms and Signs of Hyperarousal in Individuals with Fragile X Syndrome: Findings from the FORWARD Registry and Database Multisite Study.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Lachiewicz, Ave M.
      – PersonEntity:
          Name:
            NameFull: Stackhouse, Tracy M.
      – PersonEntity:
          Name:
            NameFull: Burgess, Kristin
      – PersonEntity:
          Name:
            NameFull: Burgess, Debra
      – PersonEntity:
          Name:
            NameFull: Andrews, Howard F.
      – PersonEntity:
          Name:
            NameFull: Choo, Tse-Hwei
      – PersonEntity:
          Name:
            NameFull: Kaufmann, Walter E.
      – PersonEntity:
          Name:
            NameFull: Kidd, Sharon A.
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 11
              Text: Nov2024
              Type: published
              Y: 2024
          Identifiers:
            – Type: issn-print
              Value: 01623257
          Numbering:
            – Type: volume
              Value: 54
            – Type: issue
              Value: 11
          Titles:
            – TitleFull: Journal of Autism & Developmental Disorders
              Type: main
ResultId 1