The influence of paraventricular nucleus of the hypothalamus soluble guanylate cyclase on autonomic and neuroendocrine responses to acute restraint stress in rats.
Saved in:
| Title: | The influence of paraventricular nucleus of the hypothalamus soluble guanylate cyclase on autonomic and neuroendocrine responses to acute restraint stress in rats. |
|---|---|
| Authors: | Busnardo, Cristiane (AUTHOR), Crestani, Carlos C. (AUTHOR), Fassini, Aline (AUTHOR), Scarambone, Bianca M. (AUTHOR), Packard, Benjamin A. (AUTHOR), Resstel, Leonardo B. M. (AUTHOR), Herman, James P. (AUTHOR), Correa, Fernando M. A. (AUTHOR) |
| Source: | European Journal of Neuroscience. Oct2024, Vol. 60 Issue 8, p5849-5860. 12p. |
| Subjects: | Immobilization stress, Guanylate cyclase, Skin temperature, Paraventricular nucleus, Pressure drop (Fluid dynamics), Hypothalamus |
| Abstract: | The paraventricular nucleus of the hypothalamus (PVN) regulates physiological and behavioural responses evoked by stressful stimuli, but the local neurochemical and signalling mechanisms involved are not completely understood. The soluble guanylate cyclase (sGC) within the PVN is implicated in autonomic and cardiovascular control in rodents under resting conditions. However, the involvement of PVN sGC‐mediated signalling in stress responses is unknown. Therefore, we investigated the role of sGC within the PVN in cardiovascular, autonomic, neuroendocrine, and local neuronal responses to acute restraint stress in rats. Bilateral microinjection of the selective sGC inhibitor ODQ (1 nmol/100 nl) into the PVN reduced both the increased arterial pressure and the drop in cutaneous tail temperature evoked by restraint stress, while the tachycardia was enhanced. Intra‐PVN injection of ODQ did not alter the number of Fos‐immunoreactive neurons in either the dorsal cap parvocellular (PaDC), ventromedial (PaV), medial parvocellular (PaMP), or lateral magnocelllular (PaLM) portions of the PVN following acute restraint stress. Local microinjection of ODQ into the PVN did not affect the restraint‐induced increases in plasma corticosterone concentration. Taken together, these findings suggest that sGC‐mediated signalling in the PVN plays a key role in acute stress‐induced pressor responses and sympathetically mediated cutaneous vasoconstriction, whereas the tachycardiac response is inhibited. Absence of an effect of ODQ on corticosterone and PVN neuronal activation in and the PaV and PaMP suggests that PVN sGC is not involved in restraint‐evoked hypothalamus‐pituitary‐adrenal (HPA) axis activation and further indicates that autonomic and neuroendocrine responses are dissociable at the level of the PVN. [ABSTRACT FROM AUTHOR] |
| Copyright of European Journal of Neuroscience is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
|
Full text is not displayed to guests.
Login for full access.
|
|
| FullText | Links: – Type: pdflink Text: Availability: 1 |
|---|---|
| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 180294356 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
| IllustrationInfo | |
| Items | – Name: Title Label: Title Group: Ti Data: The influence of paraventricular nucleus of the hypothalamus soluble guanylate cyclase on autonomic and neuroendocrine responses to acute restraint stress in rats. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Busnardo%2C+Cristiane%22">Busnardo, Cristiane</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Crestani%2C+Carlos+C%2E%22">Crestani, Carlos C.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Fassini%2C+Aline%22">Fassini, Aline</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Scarambone%2C+Bianca+M%2E%22">Scarambone, Bianca M.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Packard%2C+Benjamin+A%2E%22">Packard, Benjamin A.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Resstel%2C+Leonardo+B%2E+M%2E%22">Resstel, Leonardo B. M.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Herman%2C+James+P%2E%22">Herman, James P.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Correa%2C+Fernando+M%2E+A%2E%22">Correa, Fernando M. A.</searchLink> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22European+Journal+of+Neuroscience%22">European Journal of Neuroscience</searchLink>. Oct2024, Vol. 60 Issue 8, p5849-5860. 12p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Immobilization+stress%22">Immobilization stress</searchLink><br /><searchLink fieldCode="DE" term="%22Guanylate+cyclase%22">Guanylate cyclase</searchLink><br /><searchLink fieldCode="DE" term="%22Skin+temperature%22">Skin temperature</searchLink><br /><searchLink fieldCode="DE" term="%22Paraventricular+nucleus%22">Paraventricular nucleus</searchLink><br /><searchLink fieldCode="DE" term="%22Pressure+drop+%28Fluid+dynamics%29%22">Pressure drop (Fluid dynamics)</searchLink><br /><searchLink fieldCode="DE" term="%22Hypothalamus%22">Hypothalamus</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: The paraventricular nucleus of the hypothalamus (PVN) regulates physiological and behavioural responses evoked by stressful stimuli, but the local neurochemical and signalling mechanisms involved are not completely understood. The soluble guanylate cyclase (sGC) within the PVN is implicated in autonomic and cardiovascular control in rodents under resting conditions. However, the involvement of PVN sGC‐mediated signalling in stress responses is unknown. Therefore, we investigated the role of sGC within the PVN in cardiovascular, autonomic, neuroendocrine, and local neuronal responses to acute restraint stress in rats. Bilateral microinjection of the selective sGC inhibitor ODQ (1 nmol/100 nl) into the PVN reduced both the increased arterial pressure and the drop in cutaneous tail temperature evoked by restraint stress, while the tachycardia was enhanced. Intra‐PVN injection of ODQ did not alter the number of Fos‐immunoreactive neurons in either the dorsal cap parvocellular (PaDC), ventromedial (PaV), medial parvocellular (PaMP), or lateral magnocelllular (PaLM) portions of the PVN following acute restraint stress. Local microinjection of ODQ into the PVN did not affect the restraint‐induced increases in plasma corticosterone concentration. Taken together, these findings suggest that sGC‐mediated signalling in the PVN plays a key role in acute stress‐induced pressor responses and sympathetically mediated cutaneous vasoconstriction, whereas the tachycardiac response is inhibited. Absence of an effect of ODQ on corticosterone and PVN neuronal activation in and the PaV and PaMP suggests that PVN sGC is not involved in restraint‐evoked hypothalamus‐pituitary‐adrenal (HPA) axis activation and further indicates that autonomic and neuroendocrine responses are dissociable at the level of the PVN. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of European Journal of Neuroscience is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=180294356 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1111/ejn.16527 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 12 StartPage: 5849 Subjects: – SubjectFull: Immobilization stress Type: general – SubjectFull: Guanylate cyclase Type: general – SubjectFull: Skin temperature Type: general – SubjectFull: Paraventricular nucleus Type: general – SubjectFull: Pressure drop (Fluid dynamics) Type: general – SubjectFull: Hypothalamus Type: general Titles: – TitleFull: The influence of paraventricular nucleus of the hypothalamus soluble guanylate cyclase on autonomic and neuroendocrine responses to acute restraint stress in rats. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Busnardo, Cristiane – PersonEntity: Name: NameFull: Crestani, Carlos C. – PersonEntity: Name: NameFull: Fassini, Aline – PersonEntity: Name: NameFull: Scarambone, Bianca M. – PersonEntity: Name: NameFull: Packard, Benjamin A. – PersonEntity: Name: NameFull: Resstel, Leonardo B. M. – PersonEntity: Name: NameFull: Herman, James P. – PersonEntity: Name: NameFull: Correa, Fernando M. A. IsPartOfRelationships: – BibEntity: Dates: – D: 15 M: 10 Text: Oct2024 Type: published Y: 2024 Identifiers: – Type: issn-print Value: 0953816X Numbering: – Type: volume Value: 60 – Type: issue Value: 8 Titles: – TitleFull: European Journal of Neuroscience Type: main |
| ResultId | 1 |
