Exploring the Association Between Residual Mood Symptoms and Self‐Reported Side Effects in the Euthymic Phase of Bipolar Disorders: A Cross‐Sectional Network Analysis.
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| Title: | Exploring the Association Between Residual Mood Symptoms and Self‐Reported Side Effects in the Euthymic Phase of Bipolar Disorders: A Cross‐Sectional Network Analysis. |
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| Authors: | Vidal, Nathan (AUTHOR), Brunet-Gouet, Eric (AUTHOR), Frileux, Solène (AUTHOR), Aubin, Valérie (AUTHOR), Belzeaux, Raoul (AUTHOR), Courtet, Philippe (AUTHOR), D'Amato, Thierry (AUTHOR), Dubertret, Caroline (AUTHOR), Etain, Bruno (AUTHOR), Gard, Sebastien (AUTHOR), Haffen, Emmanuel (AUTHOR), Januel, Dominique (AUTHOR), Leboyer, Marion (AUTHOR), Lefrere, Antoine (AUTHOR), Llorca, Pierre-Michel (AUTHOR), Marlinge, Emeline (AUTHOR), Olié, Emilie (AUTHOR), Polosan, Mircea (AUTHOR), Schwan, Raymund (AUTHOR), Walter, Michel (AUTHOR) |
| Source: | Depression & Anxiety (1091-4269). 10/24/2024, Vol. 2024, p1-17. 17p. |
| Subjects: | Drug side effects, Bipolar disorder, Energy dissipation, Symptoms, Palpitation |
| Abstract: | Introduction: Bipolar disorders (BD) are characterized by mood symptoms that can worsen medication side effects. We aimed to study the association between residual mood signs and self‐reported side effects in the euthymic phase of BD. Methods: We assessed residual mood signs using the Montgomery–Asberg Depression Rating scale (MADRS) and Young Mania Rating scale (YMRS) and self‐reported side effects using the Patient‐Rated Inventory of Side Effects (PRISE‐M) for 880 males and 1369 females with BD. We conducted a network analysis to test the associations between 52 items of the three scales for males and females separately. We then identified clusters of nodes that fit the networks well. Results: We report only positive associations between residual mood signs and side effects. An elevated mood (YMRS) in females and increased energy (YMRS) in males were central nodes, strongly influencing the development of additional mood symptoms and side effects. Furthermore, we identified three clusters of nodes in both sexes: (1) a "mood cluster", including most YMRS and MADRS items and the PRISE‐M items evaluating sedation, sleep, and restlessness, (2) a cluster of nonsexual side effects (mostly PRISE‐M items), and (3) a cluster of sexual side effects. In both sexes, we identified bridge nodes that may favor the communication between mood and side effects, namely palpitations (PRISE‐M) and agitation (PRISE‐M). Conclusions: The results justify the particular attention of practitioners to monitor elevated moods or increased energy to try to reduce self‐reported side effects and other residual mood symptoms in the euthymic phase of BD. Our findings suggest that clinicians could consider patient‐reported loss of energy, difficulty in falling asleep, and restlessness as mood symptoms rather than medications' side effects. Palpitations and agitation may contribute to the development of additional mood symptoms or somatic complaints. [ABSTRACT FROM AUTHOR] |
| Copyright of Depression & Anxiety (1091-4269) is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 180475201 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Exploring the Association Between Residual Mood Symptoms and Self‐Reported Side Effects in the Euthymic Phase of Bipolar Disorders: A Cross‐Sectional Network Analysis. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Vidal%2C+Nathan%22">Vidal, Nathan</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Brunet-Gouet%2C+Eric%22">Brunet-Gouet, Eric</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Frileux%2C+Solène%22">Frileux, Solène</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Aubin%2C+Valérie%22">Aubin, Valérie</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Belzeaux%2C+Raoul%22">Belzeaux, Raoul</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Courtet%2C+Philippe%22">Courtet, Philippe</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22D'Amato%2C+Thierry%22">D'Amato, Thierry</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Dubertret%2C+Caroline%22">Dubertret, Caroline</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Etain%2C+Bruno%22">Etain, Bruno</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Gard%2C+Sebastien%22">Gard, Sebastien</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Haffen%2C+Emmanuel%22">Haffen, Emmanuel</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Januel%2C+Dominique%22">Januel, Dominique</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Leboyer%2C+Marion%22">Leboyer, Marion</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lefrere%2C+Antoine%22">Lefrere, Antoine</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Llorca%2C+Pierre-Michel%22">Llorca, Pierre-Michel</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Marlinge%2C+Emeline%22">Marlinge, Emeline</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Olié%2C+Emilie%22">Olié, Emilie</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Polosan%2C+Mircea%22">Polosan, Mircea</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Schwan%2C+Raymund%22">Schwan, Raymund</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Walter%2C+Michel%22">Walter, Michel</searchLink> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Depression+%26+Anxiety+%281091-4269%29%22">Depression & Anxiety (1091-4269)</searchLink>. 10/24/2024, Vol. 2024, p1-17. 17p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Drug+side+effects%22">Drug side effects</searchLink><br /><searchLink fieldCode="DE" term="%22Bipolar+disorder%22">Bipolar disorder</searchLink><br /><searchLink fieldCode="DE" term="%22Energy+dissipation%22">Energy dissipation</searchLink><br /><searchLink fieldCode="DE" term="%22Symptoms%22">Symptoms</searchLink><br /><searchLink fieldCode="DE" term="%22Palpitation%22">Palpitation</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Introduction: Bipolar disorders (BD) are characterized by mood symptoms that can worsen medication side effects. We aimed to study the association between residual mood signs and self‐reported side effects in the euthymic phase of BD. Methods: We assessed residual mood signs using the Montgomery–Asberg Depression Rating scale (MADRS) and Young Mania Rating scale (YMRS) and self‐reported side effects using the Patient‐Rated Inventory of Side Effects (PRISE‐M) for 880 males and 1369 females with BD. We conducted a network analysis to test the associations between 52 items of the three scales for males and females separately. We then identified clusters of nodes that fit the networks well. Results: We report only positive associations between residual mood signs and side effects. An elevated mood (YMRS) in females and increased energy (YMRS) in males were central nodes, strongly influencing the development of additional mood symptoms and side effects. Furthermore, we identified three clusters of nodes in both sexes: (1) a "mood cluster", including most YMRS and MADRS items and the PRISE‐M items evaluating sedation, sleep, and restlessness, (2) a cluster of nonsexual side effects (mostly PRISE‐M items), and (3) a cluster of sexual side effects. In both sexes, we identified bridge nodes that may favor the communication between mood and side effects, namely palpitations (PRISE‐M) and agitation (PRISE‐M). Conclusions: The results justify the particular attention of practitioners to monitor elevated moods or increased energy to try to reduce self‐reported side effects and other residual mood symptoms in the euthymic phase of BD. Our findings suggest that clinicians could consider patient‐reported loss of energy, difficulty in falling asleep, and restlessness as mood symptoms rather than medications' side effects. Palpitations and agitation may contribute to the development of additional mood symptoms or somatic complaints. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Depression & Anxiety (1091-4269) is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1155/2024/3375145 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 17 StartPage: 1 Subjects: – SubjectFull: Drug side effects Type: general – SubjectFull: Bipolar disorder Type: general – SubjectFull: Energy dissipation Type: general – SubjectFull: Symptoms Type: general – SubjectFull: Palpitation Type: general Titles: – TitleFull: Exploring the Association Between Residual Mood Symptoms and Self‐Reported Side Effects in the Euthymic Phase of Bipolar Disorders: A Cross‐Sectional Network Analysis. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Vidal, Nathan – PersonEntity: Name: NameFull: Brunet-Gouet, Eric – PersonEntity: Name: NameFull: Frileux, Solène – PersonEntity: Name: NameFull: Aubin, Valérie – PersonEntity: Name: NameFull: Belzeaux, Raoul – PersonEntity: Name: NameFull: Courtet, Philippe – PersonEntity: Name: NameFull: D'Amato, Thierry – PersonEntity: Name: NameFull: Dubertret, Caroline – PersonEntity: Name: NameFull: Etain, Bruno – PersonEntity: Name: NameFull: Gard, Sebastien – PersonEntity: Name: NameFull: Haffen, Emmanuel – PersonEntity: Name: NameFull: Januel, Dominique – PersonEntity: Name: NameFull: Leboyer, Marion – PersonEntity: Name: NameFull: Lefrere, Antoine – PersonEntity: Name: NameFull: Llorca, Pierre-Michel – PersonEntity: Name: NameFull: Marlinge, Emeline – PersonEntity: Name: NameFull: Olié, Emilie – PersonEntity: Name: NameFull: Polosan, Mircea – PersonEntity: Name: NameFull: Schwan, Raymund – PersonEntity: Name: NameFull: Walter, Michel IsPartOfRelationships: – BibEntity: Dates: – D: 24 M: 10 Text: 10/24/2024 Type: published Y: 2024 Identifiers: – Type: issn-print Value: 10914269 Numbering: – Type: volume Value: 2024 Titles: – TitleFull: Depression & Anxiety (1091-4269) Type: main |
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