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Acceptability of an automated directly observed therapy (DOT) application for PrEP adherence support among young men who have sex with men: a qualitative exploration.

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Title: Acceptability of an automated directly observed therapy (DOT) application for PrEP adherence support among young men who have sex with men: a qualitative exploration.
Authors: Velloza, Jennifer, Liu, Albert Y., Katz, Ariana W. K., van der Straten, Ariane, Siegler, Aaron J., Scott, Hyman, Wilde, Gretchen, Lockard, Annie, Christie, Richard H., Buchbinder, Susan P.
Source: AIDS Care. Nov2024, Vol. 36 Issue 11, p1704-1718. 15p.
Subjects: Mobile apps, Patient compliance, Qualitative research, Research funding, Interviewing, Statistical sampling, Descriptive statistics, Randomized controlled trials, Pre-exposure prophylaxis, Men who have sex with men, Directly observed therapy, Drugs
Abstract: Pre-exposure prophylaxis (PrEP) adherence remains a challenge among young men who have sex with men (MSM). We developed and tested a smartphone application ("app"), "DOT Diary", which combines automated directly observed therapy (DOT) with information about PrEP protection levels, pill-taking reminders, a sexual behavior diary, and a PrEP dosing calendar. To contextualize trial results, we qualitatively explored participants' app experiences. The trial enrolled 100 young MSM in San Francisco and Atlanta. Participants were randomized 2:1 to DOT Diary versus standard-of-care and followed for 24 weeks. Interviews were conducted with 24 intervention participants. Data were analyzed using a memo-writing approach. Most expressed overall satisfaction with the app ("it was good for its purpose"), despite concerns about technical glitches. The most popular app features were the monthly calendar showing days PrEP was taken and information about level of protection based on pills taken. The DOT component helped participants establish PrEP routines. The reminders were "annoying but effective" at motivating dosing. Opinions about the sexual behavior diary varied. Overall, DOT Diary was acceptable; participants were willing to use it daily to record pill-taking. Critical components included the information about PrEP protection levels and calendar, while others may be modified to improve future success. Trial registration: ClinicalTrials.gov identifier: NCT03771638. [ABSTRACT FROM AUTHOR]
Copyright of AIDS Care is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Acceptability of an automated directly observed therapy (DOT) application for PrEP adherence support among young men who have sex with men: a qualitative exploration.
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  Data: <searchLink fieldCode="AR" term="%22Velloza%2C+Jennifer%22">Velloza, Jennifer</searchLink><br /><searchLink fieldCode="AR" term="%22Liu%2C+Albert+Y%2E%22">Liu, Albert Y.</searchLink><br /><searchLink fieldCode="AR" term="%22Katz%2C+Ariana+W%2E+K%2E%22">Katz, Ariana W. K.</searchLink><br /><searchLink fieldCode="AR" term="%22van+der+Straten%2C+Ariane%22">van der Straten, Ariane</searchLink><br /><searchLink fieldCode="AR" term="%22Siegler%2C+Aaron+J%2E%22">Siegler, Aaron J.</searchLink><br /><searchLink fieldCode="AR" term="%22Scott%2C+Hyman%22">Scott, Hyman</searchLink><br /><searchLink fieldCode="AR" term="%22Wilde%2C+Gretchen%22">Wilde, Gretchen</searchLink><br /><searchLink fieldCode="AR" term="%22Lockard%2C+Annie%22">Lockard, Annie</searchLink><br /><searchLink fieldCode="AR" term="%22Christie%2C+Richard+H%2E%22">Christie, Richard H.</searchLink><br /><searchLink fieldCode="AR" term="%22Buchbinder%2C+Susan+P%2E%22">Buchbinder, Susan P.</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22AIDS+Care%22">AIDS Care</searchLink>. Nov2024, Vol. 36 Issue 11, p1704-1718. 15p.
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  Data: <searchLink fieldCode="DE" term="%22Mobile+apps%22">Mobile apps</searchLink><br /><searchLink fieldCode="DE" term="%22Patient+compliance%22">Patient compliance</searchLink><br /><searchLink fieldCode="DE" term="%22Qualitative+research%22">Qualitative research</searchLink><br /><searchLink fieldCode="DE" term="%22Research+funding%22">Research funding</searchLink><br /><searchLink fieldCode="DE" term="%22Interviewing%22">Interviewing</searchLink><br /><searchLink fieldCode="DE" term="%22Statistical+sampling%22">Statistical sampling</searchLink><br /><searchLink fieldCode="DE" term="%22Descriptive+statistics%22">Descriptive statistics</searchLink><br /><searchLink fieldCode="DE" term="%22Randomized+controlled+trials%22">Randomized controlled trials</searchLink><br /><searchLink fieldCode="DE" term="%22Pre-exposure+prophylaxis%22">Pre-exposure prophylaxis</searchLink><br /><searchLink fieldCode="DE" term="%22Men+who+have+sex+with+men%22">Men who have sex with men</searchLink><br /><searchLink fieldCode="DE" term="%22Directly+observed+therapy%22">Directly observed therapy</searchLink><br /><searchLink fieldCode="DE" term="%22Drugs%22">Drugs</searchLink>
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  Data: Pre-exposure prophylaxis (PrEP) adherence remains a challenge among young men who have sex with men (MSM). We developed and tested a smartphone application ("app"), "DOT Diary", which combines automated directly observed therapy (DOT) with information about PrEP protection levels, pill-taking reminders, a sexual behavior diary, and a PrEP dosing calendar. To contextualize trial results, we qualitatively explored participants' app experiences. The trial enrolled 100 young MSM in San Francisco and Atlanta. Participants were randomized 2:1 to DOT Diary versus standard-of-care and followed for 24 weeks. Interviews were conducted with 24 intervention participants. Data were analyzed using a memo-writing approach. Most expressed overall satisfaction with the app ("it was good for its purpose"), despite concerns about technical glitches. The most popular app features were the monthly calendar showing days PrEP was taken and information about level of protection based on pills taken. The DOT component helped participants establish PrEP routines. The reminders were "annoying but effective" at motivating dosing. Opinions about the sexual behavior diary varied. Overall, DOT Diary was acceptable; participants were willing to use it daily to record pill-taking. Critical components included the information about PrEP protection levels and calendar, while others may be modified to improve future success. Trial registration: ClinicalTrials.gov identifier: NCT03771638. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of AIDS Care is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
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        Value: 10.1080/09540121.2024.2397133
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      – Code: eng
        Text: English
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        PageCount: 15
        StartPage: 1704
    Subjects:
      – SubjectFull: Mobile apps
        Type: general
      – SubjectFull: Patient compliance
        Type: general
      – SubjectFull: Qualitative research
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      – SubjectFull: Research funding
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      – SubjectFull: Interviewing
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      – SubjectFull: Statistical sampling
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      – SubjectFull: Descriptive statistics
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      – SubjectFull: Randomized controlled trials
        Type: general
      – SubjectFull: Pre-exposure prophylaxis
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      – SubjectFull: Men who have sex with men
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      – SubjectFull: Directly observed therapy
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              Text: Nov2024
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