The impact of sex in the effectiveness of functional remediation in bipolar disorder.

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Title: The impact of sex in the effectiveness of functional remediation in bipolar disorder.
Authors: Serra‐Navarro, Maria (AUTHOR), Clougher, Derek (AUTHOR), Solé, Brisa (AUTHOR), Sánchez‐Moreno, Jose (AUTHOR), González‐Pinto, Ana (AUTHOR), Jiménez, Esther (AUTHOR), Amann, Benedikt L. (AUTHOR), Balanzá‐Martínez, Vicent (AUTHOR), Tabarés‐Seisdedos, Rafael (AUTHOR), Arango, Celso (AUTHOR), Accardo, Vivian (AUTHOR), García‐Portilla, María Paz (AUTHOR), Ibáñez, Ángela (AUTHOR), Crespo, José Manuel (AUTHOR), Ayuso‐Mateos, José Luis (AUTHOR), Amoretti, Silvia (AUTHOR), Torrent, Carla (AUTHOR), Martínez‐Aran, Anabel (AUTHOR), Vieta, Eduard (AUTHOR), Forte, Maria Florencia (AUTHOR)
Source: Acta Psychiatrica Scandinavica. Dec2024, Vol. 150 Issue 6, p543-561. 19p.
Subjects: Psychosocial functioning, Bipolar disorder, Females, Males
Abstract: Background: Functional recovery remains a core clinical objective for patients with bipolar disorder (BD). Sociodemographic, clinical, and neurocognitive variables are associated with long‐term functional impairment, yet the impact of sex differences is unclear. Functional remediation (FR) is a validated intervention aimed at achieving functional recovery in BD. The present study assessed the effect of sex differences of FR on psychosocial functioning at post‐treatment (6‐months) and 12‐month follow‐up (FUP). To the best of our knowledge, this is the first study to explore the role of sex as a factor in the efficacy of FR. Methods: 157 participants with BD were randomly assigned to either FR (N = 77) or treatment as usual group (80). Clinical, sociodemographic, neuropsychological, and functional data were obtained using a comprehensive assessment battery. Sex differences were explored via a general linear model (GLM) for repeated measures to compare the effect of sex on the intervention over time (6 months and FUP). Results: Results demonstrated that FR benefits both sexes, males (p = 0.001; d' = 0.88) and females (p = 0.04; d' = 0.57), at 6 months suggesting a generalized functional improvement. Conversely, at 12‐month FUP sex differences were observed only in males (p = 0.005; d' = 0.68). Conclusions: FR is a beneficial intervention for males and females after treatment, suggesting that there are no relevant distinct needs. Females may benefit from ongoing psychosocial functioning booster sessions after the intervention to maintain original improvements. Future research exploring sex differences could help to identify strategies to offer personalized FR intervention approaches in individuals with BD. [ABSTRACT FROM AUTHOR]
Copyright of Acta Psychiatrica Scandinavica is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: The impact of sex in the effectiveness of functional remediation in bipolar disorder.
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  Data: <searchLink fieldCode="AR" term="%22Serra‐Navarro%2C+Maria%22">Serra‐Navarro, Maria</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Clougher%2C+Derek%22">Clougher, Derek</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Solé%2C+Brisa%22">Solé, Brisa</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Sánchez‐Moreno%2C+Jose%22">Sánchez‐Moreno, Jose</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22González‐Pinto%2C+Ana%22">González‐Pinto, Ana</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Jiménez%2C+Esther%22">Jiménez, Esther</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Amann%2C+Benedikt+L%2E%22">Amann, Benedikt L.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Balanzá‐Martínez%2C+Vicent%22">Balanzá‐Martínez, Vicent</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Tabarés‐Seisdedos%2C+Rafael%22">Tabarés‐Seisdedos, Rafael</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Arango%2C+Celso%22">Arango, Celso</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Accardo%2C+Vivian%22">Accardo, Vivian</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22García‐Portilla%2C+María+Paz%22">García‐Portilla, María Paz</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ibáñez%2C+Ángela%22">Ibáñez, Ángela</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Crespo%2C+José+Manuel%22">Crespo, José Manuel</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ayuso‐Mateos%2C+José+Luis%22">Ayuso‐Mateos, José Luis</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Amoretti%2C+Silvia%22">Amoretti, Silvia</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Torrent%2C+Carla%22">Torrent, Carla</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Martínez‐Aran%2C+Anabel%22">Martínez‐Aran, Anabel</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Vieta%2C+Eduard%22">Vieta, Eduard</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Forte%2C+Maria+Florencia%22">Forte, Maria Florencia</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Acta+Psychiatrica+Scandinavica%22">Acta Psychiatrica Scandinavica</searchLink>. Dec2024, Vol. 150 Issue 6, p543-561. 19p.
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  Data: <searchLink fieldCode="DE" term="%22Psychosocial+functioning%22">Psychosocial functioning</searchLink><br /><searchLink fieldCode="DE" term="%22Bipolar+disorder%22">Bipolar disorder</searchLink><br /><searchLink fieldCode="DE" term="%22Females%22">Females</searchLink><br /><searchLink fieldCode="DE" term="%22Males%22">Males</searchLink>
– Name: Abstract
  Label: Abstract
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  Data: Background: Functional recovery remains a core clinical objective for patients with bipolar disorder (BD). Sociodemographic, clinical, and neurocognitive variables are associated with long‐term functional impairment, yet the impact of sex differences is unclear. Functional remediation (FR) is a validated intervention aimed at achieving functional recovery in BD. The present study assessed the effect of sex differences of FR on psychosocial functioning at post‐treatment (6‐months) and 12‐month follow‐up (FUP). To the best of our knowledge, this is the first study to explore the role of sex as a factor in the efficacy of FR. Methods: 157 participants with BD were randomly assigned to either FR (N = 77) or treatment as usual group (80). Clinical, sociodemographic, neuropsychological, and functional data were obtained using a comprehensive assessment battery. Sex differences were explored via a general linear model (GLM) for repeated measures to compare the effect of sex on the intervention over time (6 months and FUP). Results: Results demonstrated that FR benefits both sexes, males (p = 0.001; d' = 0.88) and females (p = 0.04; d' = 0.57), at 6 months suggesting a generalized functional improvement. Conversely, at 12‐month FUP sex differences were observed only in males (p = 0.005; d' = 0.68). Conclusions: FR is a beneficial intervention for males and females after treatment, suggesting that there are no relevant distinct needs. Females may benefit from ongoing psychosocial functioning booster sessions after the intervention to maintain original improvements. Future research exploring sex differences could help to identify strategies to offer personalized FR intervention approaches in individuals with BD. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Acta Psychiatrica Scandinavica is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1111/acps.13748
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        Text: English
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