View in EDS HTML Full Text PDF Full Text

Identification of risk loci for postpartum depression in a genome‐wide association study.

Saved in:
Bibliographic Details
Title: Identification of risk loci for postpartum depression in a genome‐wide association study.
Authors: Li, Xue (AUTHOR), Takahashi, Nagahide (AUTHOR), Narita, Akira (AUTHOR), Nakamura, Yukako (AUTHOR), Sakurai‐Yageta, Mika (AUTHOR), Murakami, Keiko (AUTHOR), Ishikuro, Mami (AUTHOR), Obara, Taku (AUTHOR), Kikuya, Masahiro (AUTHOR), Ueno, Fumihiko (AUTHOR), Metoki, Hirohito (AUTHOR), Ohseto, Hisashi (AUTHOR), Takahashi, Ippei (AUTHOR), Nakamura, Tomohiro (AUTHOR), Warita, Noriko (AUTHOR), Shoji, Tomoka (AUTHOR), Yu, Zhiqian (AUTHOR), Ono, Chiaki (AUTHOR), Kobayashi, Natsuko (AUTHOR), Kikuchi, Saya (AUTHOR)
Source: Psychiatry & Clinical Neurosciences. Nov2024, Vol. 78 Issue 11, p712-720. 9p.
Subjects: Edinburgh Postnatal Depression Scale, Postpartum depression, Logistic regression analysis, Japanese women, Depression in women
Abstract: Aim: Genome‐wide association studies (GWAS) of postpartum depression (PPD) based on accumulated cohorts with multiple ethnic backgrounds have failed to identify significantly associated loci. Herein, we conducted a GWAS of Japanese perinatal women along with detailed confounding information to uncover PPD‐associated loci. Methods: The first and second cohorts (n = 9260 and n = 8582 perinatal women enrolled in the Tohoku Medical Megabank Project) and the third cohort (n = 997), recruited at Nagoya University, underwent genotyping. Of them, 1421, 1264, and 225 were classified as PPD based on the Edinburgh Postnatal Depression Scale 1 month after delivery. The most influential confounding factors of genetic liability to PPD were selected, and logistic regression analyses were performed to evaluate genetic associations with PPD after adjusting for confounders. Results: A meta‐analysis of GWAS results from the three cohorts identified significant associations between PPD and the following loci (P < 5 × 10−8) by integrating the number of deliveries and the number of family members living together as the most influential confounders: rs377546683 at DAB1, rs11940752 near UGT8, rs141172317, rs117928019, rs76631412, rs118131805 at DOCK2, rs188907279 near ZNF572, rs504378, rs690150, rs491868, rs689917, rs474978, rs690118, rs690253 near DIRAS2, rs1435984417 at ZNF618, rs57705782 near PTPRM, and rs185293917 near PDGFB. Pathway analyses indicated that SNPs suggestively associated with PPD were mostly over‐represented in categories including long‐term depression, GnRH signaling, glutamatergic synapse, oxytocin signaling, and Rap1 signaling. Conclusion: The current GWAS study identified eight loci significantly associated with PPD, which may clarify the genetic structure underlying its pathogenesis. [ABSTRACT FROM AUTHOR]
Copyright of Psychiatry & Clinical Neurosciences is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
Full text is not displayed to guests.
FullText Links:
  – Type: pdflink
Text:
  Availability: 1
Header DbId: pbh
DbLabel: Psychology and Behavioral Sciences Collection
An: 180656113
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Identification of risk loci for postpartum depression in a genome‐wide association study.
– Name: Author
  Label: Authors
  Group: Au
  Data: &lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Li%2C+Xue%22&quot;&gt;Li, Xue&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Takahashi%2C+Nagahide%22&quot;&gt;Takahashi, Nagahide&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Narita%2C+Akira%22&quot;&gt;Narita, Akira&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Nakamura%2C+Yukako%22&quot;&gt;Nakamura, Yukako&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Sakurai‐Yageta%2C+Mika%22&quot;&gt;Sakurai‐Yageta, Mika&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Murakami%2C+Keiko%22&quot;&gt;Murakami, Keiko&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Ishikuro%2C+Mami%22&quot;&gt;Ishikuro, Mami&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Obara%2C+Taku%22&quot;&gt;Obara, Taku&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Kikuya%2C+Masahiro%22&quot;&gt;Kikuya, Masahiro&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Ueno%2C+Fumihiko%22&quot;&gt;Ueno, Fumihiko&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Metoki%2C+Hirohito%22&quot;&gt;Metoki, Hirohito&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Ohseto%2C+Hisashi%22&quot;&gt;Ohseto, Hisashi&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Takahashi%2C+Ippei%22&quot;&gt;Takahashi, Ippei&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Nakamura%2C+Tomohiro%22&quot;&gt;Nakamura, Tomohiro&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Warita%2C+Noriko%22&quot;&gt;Warita, Noriko&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Shoji%2C+Tomoka%22&quot;&gt;Shoji, Tomoka&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Yu%2C+Zhiqian%22&quot;&gt;Yu, Zhiqian&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Ono%2C+Chiaki%22&quot;&gt;Ono, Chiaki&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Kobayashi%2C+Natsuko%22&quot;&gt;Kobayashi, Natsuko&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Kikuchi%2C+Saya%22&quot;&gt;Kikuchi, Saya&lt;/searchLink&gt; (AUTHOR)
– Name: TitleSource
  Label: Source
  Group: Src
  Data: &lt;searchLink fieldCode=&quot;JN&quot; term=&quot;%22Psychiatry+%26+Clinical+Neurosciences%22&quot;&gt;Psychiatry &amp; Clinical Neurosciences&lt;/searchLink&gt;. Nov2024, Vol. 78 Issue 11, p712-720. 9p.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: &lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Edinburgh+Postnatal+Depression+Scale%22&quot;&gt;Edinburgh Postnatal Depression Scale&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Postpartum+depression%22&quot;&gt;Postpartum depression&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Logistic+regression+analysis%22&quot;&gt;Logistic regression analysis&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Japanese+women%22&quot;&gt;Japanese women&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Depression+in+women%22&quot;&gt;Depression in women&lt;/searchLink&gt;
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Aim: Genome‐wide association studies (GWAS) of postpartum depression (PPD) based on accumulated cohorts with multiple ethnic backgrounds have failed to identify significantly associated loci. Herein, we conducted a GWAS of Japanese perinatal women along with detailed confounding information to uncover PPD‐associated loci. Methods: The first and second cohorts (n = 9260 and n = 8582 perinatal women enrolled in the Tohoku Medical Megabank Project) and the third cohort (n = 997), recruited at Nagoya University, underwent genotyping. Of them, 1421, 1264, and 225 were classified as PPD based on the Edinburgh Postnatal Depression Scale 1 month after delivery. The most influential confounding factors of genetic liability to PPD were selected, and logistic regression analyses were performed to evaluate genetic associations with PPD after adjusting for confounders. Results: A meta‐analysis of GWAS results from the three cohorts identified significant associations between PPD and the following loci (P &lt; 5 &#215; 10−8) by integrating the number of deliveries and the number of family members living together as the most influential confounders: rs377546683 at DAB1, rs11940752 near UGT8, rs141172317, rs117928019, rs76631412, rs118131805 at DOCK2, rs188907279 near ZNF572, rs504378, rs690150, rs491868, rs689917, rs474978, rs690118, rs690253 near DIRAS2, rs1435984417 at ZNF618, rs57705782 near PTPRM, and rs185293917 near PDGFB. Pathway analyses indicated that SNPs suggestively associated with PPD were mostly over‐represented in categories including long‐term depression, GnRH signaling, glutamatergic synapse, oxytocin signaling, and Rap1 signaling. Conclusion: The current GWAS study identified eight loci significantly associated with PPD, which may clarify the genetic structure underlying its pathogenesis. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: &lt;i&gt;Copyright of Psychiatry &amp; Clinical Neurosciences is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder&#39;s express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.&lt;/i&gt; (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=180656113
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1111/pcn.13731
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 9
        StartPage: 712
    Subjects:
      – SubjectFull: Edinburgh Postnatal Depression Scale
        Type: general
      – SubjectFull: Postpartum depression
        Type: general
      – SubjectFull: Logistic regression analysis
        Type: general
      – SubjectFull: Japanese women
        Type: general
      – SubjectFull: Depression in women
        Type: general
    Titles:
      – TitleFull: Identification of risk loci for postpartum depression in a genome‐wide association study.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Li, Xue
      – PersonEntity:
          Name:
            NameFull: Takahashi, Nagahide
      – PersonEntity:
          Name:
            NameFull: Narita, Akira
      – PersonEntity:
          Name:
            NameFull: Nakamura, Yukako
      – PersonEntity:
          Name:
            NameFull: Sakurai‐Yageta, Mika
      – PersonEntity:
          Name:
            NameFull: Murakami, Keiko
      – PersonEntity:
          Name:
            NameFull: Ishikuro, Mami
      – PersonEntity:
          Name:
            NameFull: Obara, Taku
      – PersonEntity:
          Name:
            NameFull: Kikuya, Masahiro
      – PersonEntity:
          Name:
            NameFull: Ueno, Fumihiko
      – PersonEntity:
          Name:
            NameFull: Metoki, Hirohito
      – PersonEntity:
          Name:
            NameFull: Ohseto, Hisashi
      – PersonEntity:
          Name:
            NameFull: Takahashi, Ippei
      – PersonEntity:
          Name:
            NameFull: Nakamura, Tomohiro
      – PersonEntity:
          Name:
            NameFull: Warita, Noriko
      – PersonEntity:
          Name:
            NameFull: Shoji, Tomoka
      – PersonEntity:
          Name:
            NameFull: Yu, Zhiqian
      – PersonEntity:
          Name:
            NameFull: Ono, Chiaki
      – PersonEntity:
          Name:
            NameFull: Kobayashi, Natsuko
      – PersonEntity:
          Name:
            NameFull: Kikuchi, Saya
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 11
              Text: Nov2024
              Type: published
              Y: 2024
          Identifiers:
            – Type: issn-print
              Value: 13231316
          Numbering:
            – Type: volume
              Value: 78
            – Type: issue
              Value: 11
          Titles:
            – TitleFull: Psychiatry & Clinical Neurosciences
              Type: main
ResultId 1