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Two codependent routes lead to high-level MRSA.

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Title: Two codependent routes lead to high-level MRSA.
Authors: Adedeji-Olulana, Abimbola Feyisara, Wacnik, Katarzyna, Lafage, Lucia, Pasquina-Lemonche, Laia, Tinajero-Trejo, Mariana, Sutton, Joshua A. F., Bilyk, Bohdan, Irving, Sophie E., Portman Ross, Callum J., Meacock, Oliver J., Randerson, Sam A., Beattie, Ewan, Owen, David S., Florence, James, Durham, William M., Hornby, David P., Corrigan, Rebecca M., Green, Jeffrey, Hobbs, Jamie K., Foster, Simon J.
Source: Science (pre-March 2025). 11/1/2024, Vol. 386 Issue 6721, p573-580. 8p. 4 Diagrams.
Subjects: Methicillin-resistant staphylococcus aureus, Drug resistance in bacteria, Penicillin-binding proteins, Cell division
Abstract: Methicillin-resistant Staphylococcus aureus (MRSA), in which acquisition of mecA [which encodes the cell wall peptidoglycan biosynthesis component penicillin-binding protein 2a (PBP2a)] confers resistance to b-lactam antibiotics, is of major clinical concern. We show that, in the presence of antibiotics, MRSA adopts an alternative mode of cell division and shows an altered peptidoglycan architecture at the division septum. PBP2a can replace the transpeptidase activity of the endogenous and essential PBP2 but not that of PBP1, which is responsible for the distinctive native septal peptidoglycan architecture. Successful division without PBP1 activity requires the alternative division mode and is enabled by several possible chromosomal potentiator (pot) mutations. MRSA resensitizing agents differentially interfere with the two codependent mechanisms required for high-level antibiotic resistance, which provides opportunities for new interventions. [ABSTRACT FROM AUTHOR]
Copyright of Science (pre-March 2025) is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Two codependent routes lead to high-level MRSA.
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  Data: <searchLink fieldCode="AR" term="%22Adedeji-Olulana%2C+Abimbola+Feyisara%22">Adedeji-Olulana, Abimbola Feyisara</searchLink><br /><searchLink fieldCode="AR" term="%22Wacnik%2C+Katarzyna%22">Wacnik, Katarzyna</searchLink><br /><searchLink fieldCode="AR" term="%22Lafage%2C+Lucia%22">Lafage, Lucia</searchLink><br /><searchLink fieldCode="AR" term="%22Pasquina-Lemonche%2C+Laia%22">Pasquina-Lemonche, Laia</searchLink><br /><searchLink fieldCode="AR" term="%22Tinajero-Trejo%2C+Mariana%22">Tinajero-Trejo, Mariana</searchLink><br /><searchLink fieldCode="AR" term="%22Sutton%2C+Joshua+A%2E+F%2E%22">Sutton, Joshua A. F.</searchLink><br /><searchLink fieldCode="AR" term="%22Bilyk%2C+Bohdan%22">Bilyk, Bohdan</searchLink><br /><searchLink fieldCode="AR" term="%22Irving%2C+Sophie+E%2E%22">Irving, Sophie E.</searchLink><br /><searchLink fieldCode="AR" term="%22Portman+Ross%2C+Callum+J%2E%22">Portman Ross, Callum J.</searchLink><br /><searchLink fieldCode="AR" term="%22Meacock%2C+Oliver+J%2E%22">Meacock, Oliver J.</searchLink><br /><searchLink fieldCode="AR" term="%22Randerson%2C+Sam+A%2E%22">Randerson, Sam A.</searchLink><br /><searchLink fieldCode="AR" term="%22Beattie%2C+Ewan%22">Beattie, Ewan</searchLink><br /><searchLink fieldCode="AR" term="%22Owen%2C+David+S%2E%22">Owen, David S.</searchLink><br /><searchLink fieldCode="AR" term="%22Florence%2C+James%22">Florence, James</searchLink><br /><searchLink fieldCode="AR" term="%22Durham%2C+William+M%2E%22">Durham, William M.</searchLink><br /><searchLink fieldCode="AR" term="%22Hornby%2C+David+P%2E%22">Hornby, David P.</searchLink><br /><searchLink fieldCode="AR" term="%22Corrigan%2C+Rebecca+M%2E%22">Corrigan, Rebecca M.</searchLink><br /><searchLink fieldCode="AR" term="%22Green%2C+Jeffrey%22">Green, Jeffrey</searchLink><br /><searchLink fieldCode="AR" term="%22Hobbs%2C+Jamie+K%2E%22">Hobbs, Jamie K.</searchLink><br /><searchLink fieldCode="AR" term="%22Foster%2C+Simon+J%2E%22">Foster, Simon J.</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22Science+%28pre-March+2025%29%22">Science (pre-March 2025)</searchLink>. 11/1/2024, Vol. 386 Issue 6721, p573-580. 8p. 4 Diagrams.
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  Data: Methicillin-resistant Staphylococcus aureus (MRSA), in which acquisition of mecA [which encodes the cell wall peptidoglycan biosynthesis component penicillin-binding protein 2a (PBP2a)] confers resistance to b-lactam antibiotics, is of major clinical concern. We show that, in the presence of antibiotics, MRSA adopts an alternative mode of cell division and shows an altered peptidoglycan architecture at the division septum. PBP2a can replace the transpeptidase activity of the endogenous and essential PBP2 but not that of PBP1, which is responsible for the distinctive native septal peptidoglycan architecture. Successful division without PBP1 activity requires the alternative division mode and is enabled by several possible chromosomal potentiator (pot) mutations. MRSA resensitizing agents differentially interfere with the two codependent mechanisms required for high-level antibiotic resistance, which provides opportunities for new interventions. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Science (pre-March 2025) is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=180661936
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        Value: 10.1126/science.adn1369
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        Text: English
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      – SubjectFull: Drug resistance in bacteria
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