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Dopamine-mediated formation of a memory module in the nucleus accumbens for goal-directed navigation.

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Title: Dopamine-mediated formation of a memory module in the nucleus accumbens for goal-directed navigation.
Authors: Jung, Kanghoon (AUTHOR), Krüssel, Sarah (AUTHOR), Yoo, Sooyeon (AUTHOR), An, Myungmo (AUTHOR), Burke, Benjamin (AUTHOR), Schappaugh, Nicholas (AUTHOR), Choi, Youngjin (AUTHOR), Gu, Zirong (AUTHOR), Blackshaw, Seth (AUTHOR), Costa, Rui M. (AUTHOR), Kwon, Hyung-Bae (AUTHOR)
Source: Nature Neuroscience. Nov2024, Vol. 27 Issue 11, p2178-2192. 15p.
Abstract: Spatial memories guide navigation efficiently toward desired destinations. However, the neuronal and circuit mechanisms underlying the encoding of goal locations and its translation into goal-directed navigation remain unclear. Here we demonstrate that mice rapidly form a spatial memory of a shelter during shelter experiences, guiding escape behavior toward the goal location—a shelter—when under threat. Dopaminergic neurons in the ventral tegmental area and their projection to the nucleus accumbens (NAc) encode safety signals associated with the shelter. Optogenetically induced phasic dopamine signals are sufficient to create a place memory that directs escape navigation. Converging dopaminergic and hippocampal glutamatergic inputs to the NAc mediate the formation of a goal-related memory within a subpopulation of NAc neurons during shelter experiences. Artificial co-activation of this goal-related NAc ensemble with neurons in the dorsal periaqueductal gray was sufficient to trigger memory-guided, rather than random, escape behavior. These findings provide causal evidence of cognitive circuit modules linking memory with goal-directed action. Jung et al. show that shelter experience boosts dopamine release in the nucleus accumbens, generating a goal-location memory. Reactivating a neuronal ensemble developed from shelter experience enables memory-guided navigation to the goal during escape. [ABSTRACT FROM AUTHOR]
Copyright of Nature Neuroscience is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Dopamine-mediated formation of a memory module in the nucleus accumbens for goal-directed navigation.
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  Data: <searchLink fieldCode="AR" term="%22Jung%2C+Kanghoon%22">Jung, Kanghoon</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Krüssel%2C+Sarah%22">Krüssel, Sarah</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Yoo%2C+Sooyeon%22">Yoo, Sooyeon</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22An%2C+Myungmo%22">An, Myungmo</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Burke%2C+Benjamin%22">Burke, Benjamin</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Schappaugh%2C+Nicholas%22">Schappaugh, Nicholas</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Choi%2C+Youngjin%22">Choi, Youngjin</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Gu%2C+Zirong%22">Gu, Zirong</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Blackshaw%2C+Seth%22">Blackshaw, Seth</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Costa%2C+Rui+M%2E%22">Costa, Rui M.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kwon%2C+Hyung-Bae%22">Kwon, Hyung-Bae</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Nature+Neuroscience%22">Nature Neuroscience</searchLink>. Nov2024, Vol. 27 Issue 11, p2178-2192. 15p.
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Spatial memories guide navigation efficiently toward desired destinations. However, the neuronal and circuit mechanisms underlying the encoding of goal locations and its translation into goal-directed navigation remain unclear. Here we demonstrate that mice rapidly form a spatial memory of a shelter during shelter experiences, guiding escape behavior toward the goal location—a shelter—when under threat. Dopaminergic neurons in the ventral tegmental area and their projection to the nucleus accumbens (NAc) encode safety signals associated with the shelter. Optogenetically induced phasic dopamine signals are sufficient to create a place memory that directs escape navigation. Converging dopaminergic and hippocampal glutamatergic inputs to the NAc mediate the formation of a goal-related memory within a subpopulation of NAc neurons during shelter experiences. Artificial co-activation of this goal-related NAc ensemble with neurons in the dorsal periaqueductal gray was sufficient to trigger memory-guided, rather than random, escape behavior. These findings provide causal evidence of cognitive circuit modules linking memory with goal-directed action. Jung et al. show that shelter experience boosts dopamine release in the nucleus accumbens, generating a goal-location memory. Reactivating a neuronal ensemble developed from shelter experience enables memory-guided navigation to the goal during escape. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Nature Neuroscience is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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