The performance relationship between the EQ-5D-5L composite "Anxiety/Depression" dimension and anxiety and depression symptoms in a large, general population sample.
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| Title: | The performance relationship between the EQ-5D-5L composite "Anxiety/Depression" dimension and anxiety and depression symptoms in a large, general population sample. |
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| Authors: | Scott, Emily Stella (AUTHOR), Lubetkin, Erica I. (AUTHOR), Janssen, Mathieu F. (AUTHOR), Yfantopolous, John N. (AUTHOR), Bonsel, Gouke J. (AUTHOR), Haagsma, Juanita A. (AUTHOR) |
| Source: | Quality of Life Research. Nov2024, Vol. 33 Issue 11, p3107-3119. 13p. |
| Subjects: | Receiver operating characteristic curves, Psychometrics, Mental depression, Anxiety disorders, Anxiety, Age groups |
| Abstract: | Purpose: This cross-sectional study aims to understand the relationship between responses on the Anxiety/Depression (A/D) dimension of the EQ-5D-5L and symptoms of anxiety and depression on the GAD-7 and PHQ-9 instruments. In doing so, we investigate the comparative performance of the dimension between diagnostic groups (i.e. anxiety (GAD-7); depression (PHQ-9); anxiety & depression versus none). We additionally investigate the discriminatory performance between sub-populations based on gender, age, education and self-reported chronic conditions. Methods: 19,902 general population participants completed a health survey in May/June 2020, from five European countries and the United States. Performance of A/D was calculated using the Area Under the Receiver Operating Characteristic curve (AUROC), and was compared to having anxiety (GAD-7 ≥ 8), depression (PHQ-9 ≥ 10) and both versus none for the total population and sub-populations. Several additional sensitivity analyses were conducted, including calculations of the optimal A/D cut-off. Results: The performance in the total sample was good (AUROC > 0.8) and did not differ significantly between diagnostic groups. The performance differed significantly between the age groups, with worse performance in the younger groups, and differed between those with a singular chronic condition, with worse performance in those indicating having an anxiety or depression disorder. The performance did not differ significantly by gender, education, nor total chronic conditions. Conclusion: The A/D dimension captures symptoms of anxiety, depression or both equally well. Performance is worse in the younger population. Interpretation in those with a self-reported anxiety or depression disorder should be further investigated. This is the first-of-its-kind large population sample performance analysis, where we present evidence that the performance of the A/D dimension differs between ages, and thus intra-age comparative results may be flawed. [ABSTRACT FROM AUTHOR] |
| Copyright of Quality of Life Research is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 180735360 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: The performance relationship between the EQ-5D-5L composite "Anxiety/Depression" dimension and anxiety and depression symptoms in a large, general population sample. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Scott%2C+Emily+Stella%22">Scott, Emily Stella</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lubetkin%2C+Erica+I%2E%22">Lubetkin, Erica I.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Janssen%2C+Mathieu+F%2E%22">Janssen, Mathieu F.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Yfantopolous%2C+John+N%2E%22">Yfantopolous, John N.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Bonsel%2C+Gouke+J%2E%22">Bonsel, Gouke J.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Haagsma%2C+Juanita+A%2E%22">Haagsma, Juanita A.</searchLink> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Quality+of+Life+Research%22">Quality of Life Research</searchLink>. Nov2024, Vol. 33 Issue 11, p3107-3119. 13p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Receiver+operating+characteristic+curves%22">Receiver operating characteristic curves</searchLink><br /><searchLink fieldCode="DE" term="%22Psychometrics%22">Psychometrics</searchLink><br /><searchLink fieldCode="DE" term="%22Mental+depression%22">Mental depression</searchLink><br /><searchLink fieldCode="DE" term="%22Anxiety+disorders%22">Anxiety disorders</searchLink><br /><searchLink fieldCode="DE" term="%22Anxiety%22">Anxiety</searchLink><br /><searchLink fieldCode="DE" term="%22Age+groups%22">Age groups</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Purpose: This cross-sectional study aims to understand the relationship between responses on the Anxiety/Depression (A/D) dimension of the EQ-5D-5L and symptoms of anxiety and depression on the GAD-7 and PHQ-9 instruments. In doing so, we investigate the comparative performance of the dimension between diagnostic groups (i.e. anxiety (GAD-7); depression (PHQ-9); anxiety & depression versus none). We additionally investigate the discriminatory performance between sub-populations based on gender, age, education and self-reported chronic conditions. Methods: 19,902 general population participants completed a health survey in May/June 2020, from five European countries and the United States. Performance of A/D was calculated using the Area Under the Receiver Operating Characteristic curve (AUROC), and was compared to having anxiety (GAD-7 ≥ 8), depression (PHQ-9 ≥ 10) and both versus none for the total population and sub-populations. Several additional sensitivity analyses were conducted, including calculations of the optimal A/D cut-off. Results: The performance in the total sample was good (AUROC > 0.8) and did not differ significantly between diagnostic groups. The performance differed significantly between the age groups, with worse performance in the younger groups, and differed between those with a singular chronic condition, with worse performance in those indicating having an anxiety or depression disorder. The performance did not differ significantly by gender, education, nor total chronic conditions. Conclusion: The A/D dimension captures symptoms of anxiety, depression or both equally well. Performance is worse in the younger population. Interpretation in those with a self-reported anxiety or depression disorder should be further investigated. This is the first-of-its-kind large population sample performance analysis, where we present evidence that the performance of the A/D dimension differs between ages, and thus intra-age comparative results may be flawed. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Quality of Life Research is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1007/s11136-024-03754-5 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 13 StartPage: 3107 Subjects: – SubjectFull: Receiver operating characteristic curves Type: general – SubjectFull: Psychometrics Type: general – SubjectFull: Mental depression Type: general – SubjectFull: Anxiety disorders Type: general – SubjectFull: Anxiety Type: general – SubjectFull: Age groups Type: general Titles: – TitleFull: The performance relationship between the EQ-5D-5L composite "Anxiety/Depression" dimension and anxiety and depression symptoms in a large, general population sample. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Scott, Emily Stella – PersonEntity: Name: NameFull: Lubetkin, Erica I. – PersonEntity: Name: NameFull: Janssen, Mathieu F. – PersonEntity: Name: NameFull: Yfantopolous, John N. – PersonEntity: Name: NameFull: Bonsel, Gouke J. – PersonEntity: Name: NameFull: Haagsma, Juanita A. IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 11 Text: Nov2024 Type: published Y: 2024 Identifiers: – Type: issn-print Value: 09629343 Numbering: – Type: volume Value: 33 – Type: issue Value: 11 Titles: – TitleFull: Quality of Life Research Type: main |
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