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Decreased Functional and Structural Connectivity is Associated with Core Symptom Improvement in Children with Autism Spectrum Disorder After Mini-basketball Training Program.

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Title: Decreased Functional and Structural Connectivity is Associated with Core Symptom Improvement in Children with Autism Spectrum Disorder After Mini-basketball Training Program.
Authors: Zhou, Dongyue, Liu, Zhimei, Gong, Guanyu, Zhang, Yunge, Lin, Lin, Cai, Kelong, Xu, Huashuai, Cong, Fengyu, Li, Huanjie, Chen, Aiguo
Source: Journal of Autism & Developmental Disorders. Dec2024, Vol. 54 Issue 12, p4515-4528. 14p.
Subjects: Brain physiology, Brain anatomy, Functional connectivity, Research funding, Autism, Rehabilitation of autistic people, Clinical trials, Physical training & conditioning, Neuroanatomy, Control groups, Pre-tests & post-tests, Large-scale brain networks, Asperger's syndrome, Basketball, Symptoms, Children
Abstract: Exercise intervention has been proven helpful to ameliorate core symptoms of Autism Spectrum Disorder (ASD). However, the underlying mechanisms are not fully understood. In this study, we carried out a 12-week mini-basketball training program (MBTP) on ASD children and examined the changes of brain functional and structural networks before and after exercise intervention. We applied individual-based method to construct functional network and structural morphological network, and investigated their alterations following MBTP as well as their associations with the change in core symptom. Structural MRI and resting-state functional MRI data were obtained from 58 ASD children aged 3–12 years (experiment group: n = 32, control group: n = 26). ASD children who received MBTP intervention showed several distinguishable alternations compared to the control without special intervention. These included decreased functional connectivity within the sensorimotor network (SM) and between SM and the salience network, decreased morphological connectivity strength in a cortical-cortical network centered on the left inferior temporal gyrus, and a subcortical–cortical network centered on the left caudate. Particularly, the aforementioned functional and structural changes induced by MBTP were associated with core symptoms of ASD. Our findings suggested that MBTP intervention could be an effective approach to improve core symptoms in ASD children, decrease connectivity in both structure and function networks, and may drive the brain change towards normal-like neuroanatomy. [ABSTRACT FROM AUTHOR]
Copyright of Journal of Autism & Developmental Disorders is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Decreased Functional and Structural Connectivity is Associated with Core Symptom Improvement in Children with Autism Spectrum Disorder After Mini-basketball Training Program.
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  Data: <searchLink fieldCode="AR" term="%22Zhou%2C+Dongyue%22">Zhou, Dongyue</searchLink><br /><searchLink fieldCode="AR" term="%22Liu%2C+Zhimei%22">Liu, Zhimei</searchLink><br /><searchLink fieldCode="AR" term="%22Gong%2C+Guanyu%22">Gong, Guanyu</searchLink><br /><searchLink fieldCode="AR" term="%22Zhang%2C+Yunge%22">Zhang, Yunge</searchLink><br /><searchLink fieldCode="AR" term="%22Lin%2C+Lin%22">Lin, Lin</searchLink><br /><searchLink fieldCode="AR" term="%22Cai%2C+Kelong%22">Cai, Kelong</searchLink><br /><searchLink fieldCode="AR" term="%22Xu%2C+Huashuai%22">Xu, Huashuai</searchLink><br /><searchLink fieldCode="AR" term="%22Cong%2C+Fengyu%22">Cong, Fengyu</searchLink><br /><searchLink fieldCode="AR" term="%22Li%2C+Huanjie%22">Li, Huanjie</searchLink><br /><searchLink fieldCode="AR" term="%22Chen%2C+Aiguo%22">Chen, Aiguo</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22Journal+of+Autism+%26+Developmental+Disorders%22">Journal of Autism & Developmental Disorders</searchLink>. Dec2024, Vol. 54 Issue 12, p4515-4528. 14p.
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  Data: <searchLink fieldCode="DE" term="%22Brain+physiology%22">Brain physiology</searchLink><br /><searchLink fieldCode="DE" term="%22Brain+anatomy%22">Brain anatomy</searchLink><br /><searchLink fieldCode="DE" term="%22Functional+connectivity%22">Functional connectivity</searchLink><br /><searchLink fieldCode="DE" term="%22Research+funding%22">Research funding</searchLink><br /><searchLink fieldCode="DE" term="%22Autism%22">Autism</searchLink><br /><searchLink fieldCode="DE" term="%22Rehabilitation+of+autistic+people%22">Rehabilitation of autistic people</searchLink><br /><searchLink fieldCode="DE" term="%22Clinical+trials%22">Clinical trials</searchLink><br /><searchLink fieldCode="DE" term="%22Physical+training+%26+conditioning%22">Physical training & conditioning</searchLink><br /><searchLink fieldCode="DE" term="%22Neuroanatomy%22">Neuroanatomy</searchLink><br /><searchLink fieldCode="DE" term="%22Control+groups%22">Control groups</searchLink><br /><searchLink fieldCode="DE" term="%22Pre-tests+%26+post-tests%22">Pre-tests & post-tests</searchLink><br /><searchLink fieldCode="DE" term="%22Large-scale+brain+networks%22">Large-scale brain networks</searchLink><br /><searchLink fieldCode="DE" term="%22Asperger's+syndrome%22">Asperger's syndrome</searchLink><br /><searchLink fieldCode="DE" term="%22Basketball%22">Basketball</searchLink><br /><searchLink fieldCode="DE" term="%22Symptoms%22">Symptoms</searchLink><br /><searchLink fieldCode="DE" term="%22Children%22">Children</searchLink>
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  Label: Abstract
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  Data: Exercise intervention has been proven helpful to ameliorate core symptoms of Autism Spectrum Disorder (ASD). However, the underlying mechanisms are not fully understood. In this study, we carried out a 12-week mini-basketball training program (MBTP) on ASD children and examined the changes of brain functional and structural networks before and after exercise intervention. We applied individual-based method to construct functional network and structural morphological network, and investigated their alterations following MBTP as well as their associations with the change in core symptom. Structural MRI and resting-state functional MRI data were obtained from 58 ASD children aged 3–12 years (experiment group: n = 32, control group: n = 26). ASD children who received MBTP intervention showed several distinguishable alternations compared to the control without special intervention. These included decreased functional connectivity within the sensorimotor network (SM) and between SM and the salience network, decreased morphological connectivity strength in a cortical-cortical network centered on the left inferior temporal gyrus, and a subcortical–cortical network centered on the left caudate. Particularly, the aforementioned functional and structural changes induced by MBTP were associated with core symptoms of ASD. Our findings suggested that MBTP intervention could be an effective approach to improve core symptoms in ASD children, decrease connectivity in both structure and function networks, and may drive the brain change towards normal-like neuroanatomy. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Journal of Autism & Developmental Disorders is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=180804672
RecordInfo BibRecord:
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    Identifiers:
      – Type: doi
        Value: 10.1007/s10803-023-06160-x
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 14
        StartPage: 4515
    Subjects:
      – SubjectFull: Brain physiology
        Type: general
      – SubjectFull: Brain anatomy
        Type: general
      – SubjectFull: Functional connectivity
        Type: general
      – SubjectFull: Research funding
        Type: general
      – SubjectFull: Autism
        Type: general
      – SubjectFull: Rehabilitation of autistic people
        Type: general
      – SubjectFull: Clinical trials
        Type: general
      – SubjectFull: Physical training & conditioning
        Type: general
      – SubjectFull: Neuroanatomy
        Type: general
      – SubjectFull: Control groups
        Type: general
      – SubjectFull: Pre-tests & post-tests
        Type: general
      – SubjectFull: Large-scale brain networks
        Type: general
      – SubjectFull: Asperger's syndrome
        Type: general
      – SubjectFull: Basketball
        Type: general
      – SubjectFull: Symptoms
        Type: general
      – SubjectFull: Children
        Type: general
    Titles:
      – TitleFull: Decreased Functional and Structural Connectivity is Associated with Core Symptom Improvement in Children with Autism Spectrum Disorder After Mini-basketball Training Program.
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            – D: 01
              M: 12
              Text: Dec2024
              Type: published
              Y: 2024
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