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Antiretroviral therapy adherence among peripartum women with HIV in Kenya: an explanatory mixed methods study using dry blood spot measures and narrative interviews.

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Title: Antiretroviral therapy adherence among peripartum women with HIV in Kenya: an explanatory mixed methods study using dry blood spot measures and narrative interviews.
Authors: Hampanda, K., Grubbs, H., Castillo-Mancilla, J., Anderson, P.L., Thorne, J., Helova, A., Turan, J.M., Onono, M., Abuogi, L.L.
Source: AIDS Care. Dec2024, Vol. 36 Issue 12, p1826-1837. 12p.
Subjects: Clinical drug trials, HIV infection transmission, HIV infection epidemiology, HIV prevention, Patient compliance, DNA polymerases, Research funding, Qualitative research, Health attitudes, Mothers, HIV-positive persons, Tenofovir, Interviewing, Child health services, Pregnant women, HIV infections, Highly active antiretroviral therapy, Thematic analysis, Research methodology, Vertical transmission (Communicable diseases), Resource-limited settings, Social support, Perinatal period, Biomarkers, Chemical inhibitors
Geographic Terms: Kenya
Abstract: Adherence to antiretroviral therapy (ART) remains sub-optimal among pregnant and postpartum women with HIV (PPWH) in high HIV prevalence low resource settings with few effective behavioral interventions. A large body of qualitative literature has established general barriers and facilitators to ART adherence in PPWH at various levels (individual, interpersonal, structural). However, research exploring the underlying behavioral mechanisms of ART adherence in PPWH with objectively verified adherence biomarkers is extremely limited. We conducted 24 in-depth interviews with postpartum women in western Kenya who had linked ART drug concentrations obtained from three dried blood spot samples across the peripartum period. Among PPWH with a low drug concentration (n = 13) compared to those with continuously high drug concentrations (n = 11), distinct themes emerged related to HIV status disclosure, social support, interactions with the health system, and health beliefs. By combining ART biomarkers with patient reported challenges, there is the potential for real-time interventions to support sustained ART adherence among PPWH and improve maternal and infant health outcomes. [ABSTRACT FROM AUTHOR]
Copyright of AIDS Care is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Antiretroviral therapy adherence among peripartum women with HIV in Kenya: an explanatory mixed methods study using dry blood spot measures and narrative interviews.
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  Data: <searchLink fieldCode="JN" term="%22AIDS+Care%22">AIDS Care</searchLink>. Dec2024, Vol. 36 Issue 12, p1826-1837. 12p.
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  Data: <searchLink fieldCode="DE" term="%22Clinical+drug+trials%22">Clinical drug trials</searchLink><br /><searchLink fieldCode="DE" term="%22HIV+infection+transmission%22">HIV infection transmission</searchLink><br /><searchLink fieldCode="DE" term="%22HIV+infection+epidemiology%22">HIV infection epidemiology</searchLink><br /><searchLink fieldCode="DE" term="%22HIV+prevention%22">HIV prevention</searchLink><br /><searchLink fieldCode="DE" term="%22Patient+compliance%22">Patient compliance</searchLink><br /><searchLink fieldCode="DE" term="%22DNA+polymerases%22">DNA polymerases</searchLink><br /><searchLink fieldCode="DE" term="%22Research+funding%22">Research funding</searchLink><br /><searchLink fieldCode="DE" term="%22Qualitative+research%22">Qualitative research</searchLink><br /><searchLink fieldCode="DE" term="%22Health+attitudes%22">Health attitudes</searchLink><br /><searchLink fieldCode="DE" term="%22Mothers%22">Mothers</searchLink><br /><searchLink fieldCode="DE" term="%22HIV-positive+persons%22">HIV-positive persons</searchLink><br /><searchLink fieldCode="DE" term="%22Tenofovir%22">Tenofovir</searchLink><br /><searchLink fieldCode="DE" term="%22Interviewing%22">Interviewing</searchLink><br /><searchLink fieldCode="DE" term="%22Child+health+services%22">Child health services</searchLink><br /><searchLink fieldCode="DE" term="%22Pregnant+women%22">Pregnant women</searchLink><br /><searchLink fieldCode="DE" term="%22HIV+infections%22">HIV infections</searchLink><br /><searchLink fieldCode="DE" term="%22Highly+active+antiretroviral+therapy%22">Highly active antiretroviral therapy</searchLink><br /><searchLink fieldCode="DE" term="%22Thematic+analysis%22">Thematic analysis</searchLink><br /><searchLink fieldCode="DE" term="%22Research+methodology%22">Research methodology</searchLink><br /><searchLink fieldCode="DE" term="%22Vertical+transmission+%28Communicable+diseases%29%22">Vertical transmission (Communicable diseases)</searchLink><br /><searchLink fieldCode="DE" term="%22Resource-limited+settings%22">Resource-limited settings</searchLink><br /><searchLink fieldCode="DE" term="%22Social+support%22">Social support</searchLink><br /><searchLink fieldCode="DE" term="%22Perinatal+period%22">Perinatal period</searchLink><br /><searchLink fieldCode="DE" term="%22Biomarkers%22">Biomarkers</searchLink><br /><searchLink fieldCode="DE" term="%22Chemical+inhibitors%22">Chemical inhibitors</searchLink>
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  Data: <searchLink fieldCode="DE" term="%22Kenya%22">Kenya</searchLink>
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  Data: Adherence to antiretroviral therapy (ART) remains sub-optimal among pregnant and postpartum women with HIV (PPWH) in high HIV prevalence low resource settings with few effective behavioral interventions. A large body of qualitative literature has established general barriers and facilitators to ART adherence in PPWH at various levels (individual, interpersonal, structural). However, research exploring the underlying behavioral mechanisms of ART adherence in PPWH with objectively verified adherence biomarkers is extremely limited. We conducted 24 in-depth interviews with postpartum women in western Kenya who had linked ART drug concentrations obtained from three dried blood spot samples across the peripartum period. Among PPWH with a low drug concentration (n = 13) compared to those with continuously high drug concentrations (n = 11), distinct themes emerged related to HIV status disclosure, social support, interactions with the health system, and health beliefs. By combining ART biomarkers with patient reported challenges, there is the potential for real-time interventions to support sustained ART adherence among PPWH and improve maternal and infant health outcomes. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of AIDS Care is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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      – Type: doi
        Value: 10.1080/09540121.2024.2383885
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        Text: English
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        Type: general
      – SubjectFull: HIV infection transmission
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      – SubjectFull: HIV infection epidemiology
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      – SubjectFull: HIV prevention
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      – SubjectFull: Patient compliance
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      – SubjectFull: DNA polymerases
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      – SubjectFull: Research funding
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      – SubjectFull: Qualitative research
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      – SubjectFull: Health attitudes
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      – SubjectFull: Mothers
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      – SubjectFull: Child health services
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      – SubjectFull: Pregnant women
        Type: general
      – SubjectFull: HIV infections
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      – SubjectFull: Highly active antiretroviral therapy
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      – SubjectFull: Perinatal period
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      – SubjectFull: Biomarkers
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      – SubjectFull: Chemical inhibitors
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      – SubjectFull: Kenya
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      – TitleFull: Antiretroviral therapy adherence among peripartum women with HIV in Kenya: an explanatory mixed methods study using dry blood spot measures and narrative interviews.
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              Text: Dec2024
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