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The spectrum of anti-GQ1B antibody syndrome: beyond Miller Fisher syndrome and Bickerstaff brainstem encephalitis.

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Title: The spectrum of anti-GQ1B antibody syndrome: beyond Miller Fisher syndrome and Bickerstaff brainstem encephalitis.
Authors: Noioso, Ciro Maria (AUTHOR), Bevilacqua, Liliana (AUTHOR), Acerra, Gabriella Maria (AUTHOR), Valle, Paola Della (AUTHOR), Serio, Marina (AUTHOR), Pecoraro, Agnese (AUTHOR), Rienzo, Annalisa (AUTHOR), De Marca, Umberto (AUTHOR), De Biasi, Giuseppe (AUTHOR), Vinciguerra, Claudia (AUTHOR), Piscosquito, Giuseppe (AUTHOR), Toriello, Antonella (AUTHOR), Tozza, Stefano (AUTHOR), Barone, Paolo (AUTHOR), Iovino, Aniello (AUTHOR)
Source: Neurological Sciences. Dec2024, Vol. 45 Issue 12, p5657-5669. 13p.
Subjects: Central nervous system, Guillain-Barré syndrome, Encephalitis, Brain stem, Immunoglobulin G
Abstract: Introduction: Since the initial identification of Miller Fisher syndrome (MFS) and Bickerstaff brainstem encephalitis (BBE),significant milestones have been achieved in understanding these diseases.Discoveries of common serum antibodies (IgG anti-GQ1b), antecedent infections, neurophysiological data, andneuroimaging suggested a shared autoimmune pathogenetic mechanism rather than distinct pathogenesis, leadingto the hypothesis that both diseases are part of a unified syndrome, termed "Fisher-Bickerstaff syndrome". The subsequent identification of atypical anti-GQ1b-positive forms expanded the classification to a broader condition known as "Anti-GQ1b-Antibody syndrome". Methods: An exhaustive literature review was conducted, analyzing a substantial body of research spanning from the initialdescriptions of the syndrome's components to recent developments in diagnostic classification and researchperspectives. Results: Anti-GQ1b syndrome encompasses a continuous spectrum of conditions defined by a common serological profilewith varying degrees of peripheral (PNS) and central nervous system (CNS) involvement. MFS and BBE represent theopposite ends of this spectrum, with MFS primarily affecting the PNS and BBE predominantly involving the CNS.Recently identified atypical forms, such as acute ophthalmoparesis, acute ataxic neuropathy withoutophthalmoparesis, Guillain-Barré syndrome (GBS) with ophthalmoparesis, MFS-GBS and BBE-GBS overlap syndromes,have broadened this spectrum. Conclusion: This work aims to provide an extensive, detailed, and updated overview of all aspects of the anti-GQ1b syndromewith the intention of serving as a stepping stone for further shaping thereof. Special attention was given to therecently identified atypical forms, underscoring their significance in redefining the boundaries of the syndrome. [ABSTRACT FROM AUTHOR]
Copyright of Neurological Sciences is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: The spectrum of anti-GQ1B antibody syndrome: beyond Miller Fisher syndrome and Bickerstaff brainstem encephalitis.
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  Data: <searchLink fieldCode="AR" term="%22Noioso%2C+Ciro+Maria%22">Noioso, Ciro Maria</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Bevilacqua%2C+Liliana%22">Bevilacqua, Liliana</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Acerra%2C+Gabriella+Maria%22">Acerra, Gabriella Maria</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Valle%2C+Paola+Della%22">Valle, Paola Della</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Serio%2C+Marina%22">Serio, Marina</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Pecoraro%2C+Agnese%22">Pecoraro, Agnese</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Rienzo%2C+Annalisa%22">Rienzo, Annalisa</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22De+Marca%2C+Umberto%22">De Marca, Umberto</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22De+Biasi%2C+Giuseppe%22">De Biasi, Giuseppe</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Vinciguerra%2C+Claudia%22">Vinciguerra, Claudia</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Piscosquito%2C+Giuseppe%22">Piscosquito, Giuseppe</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Toriello%2C+Antonella%22">Toriello, Antonella</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Tozza%2C+Stefano%22">Tozza, Stefano</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Barone%2C+Paolo%22">Barone, Paolo</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Iovino%2C+Aniello%22">Iovino, Aniello</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Neurological+Sciences%22">Neurological Sciences</searchLink>. Dec2024, Vol. 45 Issue 12, p5657-5669. 13p.
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  Data: <searchLink fieldCode="DE" term="%22Central+nervous+system%22">Central nervous system</searchLink><br /><searchLink fieldCode="DE" term="%22Guillain-Barré+syndrome%22">Guillain-Barré syndrome</searchLink><br /><searchLink fieldCode="DE" term="%22Encephalitis%22">Encephalitis</searchLink><br /><searchLink fieldCode="DE" term="%22Brain+stem%22">Brain stem</searchLink><br /><searchLink fieldCode="DE" term="%22Immunoglobulin+G%22">Immunoglobulin G</searchLink>
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  Data: Introduction: Since the initial identification of Miller Fisher syndrome (MFS) and Bickerstaff brainstem encephalitis (BBE),significant milestones have been achieved in understanding these diseases.Discoveries of common serum antibodies (IgG anti-GQ1b), antecedent infections, neurophysiological data, andneuroimaging suggested a shared autoimmune pathogenetic mechanism rather than distinct pathogenesis, leadingto the hypothesis that both diseases are part of a unified syndrome, termed "Fisher-Bickerstaff syndrome". The subsequent identification of atypical anti-GQ1b-positive forms expanded the classification to a broader condition known as "Anti-GQ1b-Antibody syndrome". Methods: An exhaustive literature review was conducted, analyzing a substantial body of research spanning from the initialdescriptions of the syndrome's components to recent developments in diagnostic classification and researchperspectives. Results: Anti-GQ1b syndrome encompasses a continuous spectrum of conditions defined by a common serological profilewith varying degrees of peripheral (PNS) and central nervous system (CNS) involvement. MFS and BBE represent theopposite ends of this spectrum, with MFS primarily affecting the PNS and BBE predominantly involving the CNS.Recently identified atypical forms, such as acute ophthalmoparesis, acute ataxic neuropathy withoutophthalmoparesis, Guillain-Barré syndrome (GBS) with ophthalmoparesis, MFS-GBS and BBE-GBS overlap syndromes,have broadened this spectrum. Conclusion: This work aims to provide an extensive, detailed, and updated overview of all aspects of the anti-GQ1b syndromewith the intention of serving as a stepping stone for further shaping thereof. Special attention was given to therecently identified atypical forms, underscoring their significance in redefining the boundaries of the syndrome. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Neurological Sciences is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1007/s10072-024-07686-3
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