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Medical Comorbidities, Nutritional Markers, and Cardiovascular Risk Markers in Youth With ARFID.

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Title: Medical Comorbidities, Nutritional Markers, and Cardiovascular Risk Markers in Youth With ARFID.
Authors: Burton‐Murray, Helen, Sella, Aluma Chovel, Gydus, Julia E., Atkins, Micaela, Palmer, Lilian P., Kuhnle, Megan C., Becker, Kendra R., Breithaupt, Lauren E., Brigham, Kathryn S., Aulinas, Anna, Staller, Kyle, Eddy, Kamryn T., Misra, Madhusmita, Micali, Nadia, Thomas, Jennifer J., Lawson, Elizabeth A.
Source: International Journal of Eating Disorders. Nov2024, Vol. 57 Issue 11, p2167-2175. 9p.
Subjects: Analysis of triglycerides, Risk assessment, Research funding, T-test (Statistics), Interviewing, Kruskal-Wallis Test, Fisher exact test, Cardiovascular diseases risk factors, Descriptive statistics, Chi-squared test, Eating disorders, Odds ratio, Confidence intervals, Data analysis software, Biomarkers, Nutrition, Comorbidity, C-reactive protein, Gastrointestinal diseases, Adolescence
Abstract: Objective: Avoidant/restrictive food intake disorder (ARFID) is common among populations with nutrition‐related medical conditions. Less is known about the medical comorbidity/complication frequencies in youth with ARFID. We evaluated the medical comorbidities and metabolic/nutritional markers among female and male youth with full/subthreshold ARFID across the weight spectrum compared with healthy controls (HC). Method: In youth with full/subthreshold ARFID (n = 100; 49% female) and HC (n = 58; 78% female), we assessed self‐reported medical comorbidities via clinician interview and explored abnormalities in metabolic (lipid panel and high‐sensitive C‐reactive protein [hs‐CRP]) and nutritional (25[OH] vitamin D, vitamin B12, and folate) markers. Results: Youth with ARFID, compared with HC, were over 10 times as likely to have self‐reported gastrointestinal conditions (37% vs. 3%; OR = 21.2; 95% CI = 6.2–112.1) and over two times as likely to have self‐reported immune‐mediated conditions (42% vs. 24%; OR = 2.3; 95% CI = 1.1–4.9). ARFID, compared with HC, had a four to five times higher frequency of elevated triglycerides (28% vs. 12%; OR = 4.0; 95% CI = 1.7–10.5) and hs‐CRP (17% vs. 4%; OR = 5.0; 95% CI = 1.4–27.0) levels. Discussion: Self‐reported gastrointestinal and certain immune comorbidities were common in ARFID, suggestive of possible bidirectional risk/maintenance factors. Elevated cardiovascular risk markers in ARFID may be a consequence of limited dietary variety marked by high carbohydrate and sugar intake. [ABSTRACT FROM AUTHOR]
Copyright of International Journal of Eating Disorders is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Medical Comorbidities, Nutritional Markers, and Cardiovascular Risk Markers in Youth With ARFID.
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  Data: <searchLink fieldCode="AR" term="%22Burton‐Murray%2C+Helen%22">Burton‐Murray, Helen</searchLink><br /><searchLink fieldCode="AR" term="%22Sella%2C+Aluma+Chovel%22">Sella, Aluma Chovel</searchLink><br /><searchLink fieldCode="AR" term="%22Gydus%2C+Julia+E%2E%22">Gydus, Julia E.</searchLink><br /><searchLink fieldCode="AR" term="%22Atkins%2C+Micaela%22">Atkins, Micaela</searchLink><br /><searchLink fieldCode="AR" term="%22Palmer%2C+Lilian+P%2E%22">Palmer, Lilian P.</searchLink><br /><searchLink fieldCode="AR" term="%22Kuhnle%2C+Megan+C%2E%22">Kuhnle, Megan C.</searchLink><br /><searchLink fieldCode="AR" term="%22Becker%2C+Kendra+R%2E%22">Becker, Kendra R.</searchLink><br /><searchLink fieldCode="AR" term="%22Breithaupt%2C+Lauren+E%2E%22">Breithaupt, Lauren E.</searchLink><br /><searchLink fieldCode="AR" term="%22Brigham%2C+Kathryn+S%2E%22">Brigham, Kathryn S.</searchLink><br /><searchLink fieldCode="AR" term="%22Aulinas%2C+Anna%22">Aulinas, Anna</searchLink><br /><searchLink fieldCode="AR" term="%22Staller%2C+Kyle%22">Staller, Kyle</searchLink><br /><searchLink fieldCode="AR" term="%22Eddy%2C+Kamryn+T%2E%22">Eddy, Kamryn T.</searchLink><br /><searchLink fieldCode="AR" term="%22Misra%2C+Madhusmita%22">Misra, Madhusmita</searchLink><br /><searchLink fieldCode="AR" term="%22Micali%2C+Nadia%22">Micali, Nadia</searchLink><br /><searchLink fieldCode="AR" term="%22Thomas%2C+Jennifer+J%2E%22">Thomas, Jennifer J.</searchLink><br /><searchLink fieldCode="AR" term="%22Lawson%2C+Elizabeth+A%2E%22">Lawson, Elizabeth A.</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22International+Journal+of+Eating+Disorders%22">International Journal of Eating Disorders</searchLink>. Nov2024, Vol. 57 Issue 11, p2167-2175. 9p.
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  Data: <searchLink fieldCode="DE" term="%22Analysis+of+triglycerides%22">Analysis of triglycerides</searchLink><br /><searchLink fieldCode="DE" term="%22Risk+assessment%22">Risk assessment</searchLink><br /><searchLink fieldCode="DE" term="%22Research+funding%22">Research funding</searchLink><br /><searchLink fieldCode="DE" term="%22T-test+%28Statistics%29%22">T-test (Statistics)</searchLink><br /><searchLink fieldCode="DE" term="%22Interviewing%22">Interviewing</searchLink><br /><searchLink fieldCode="DE" term="%22Kruskal-Wallis+Test%22">Kruskal-Wallis Test</searchLink><br /><searchLink fieldCode="DE" term="%22Fisher+exact+test%22">Fisher exact test</searchLink><br /><searchLink fieldCode="DE" term="%22Cardiovascular+diseases+risk+factors%22">Cardiovascular diseases risk factors</searchLink><br /><searchLink fieldCode="DE" term="%22Descriptive+statistics%22">Descriptive statistics</searchLink><br /><searchLink fieldCode="DE" term="%22Chi-squared+test%22">Chi-squared test</searchLink><br /><searchLink fieldCode="DE" term="%22Eating+disorders%22">Eating disorders</searchLink><br /><searchLink fieldCode="DE" term="%22Odds+ratio%22">Odds ratio</searchLink><br /><searchLink fieldCode="DE" term="%22Confidence+intervals%22">Confidence intervals</searchLink><br /><searchLink fieldCode="DE" term="%22Data+analysis+software%22">Data analysis software</searchLink><br /><searchLink fieldCode="DE" term="%22Biomarkers%22">Biomarkers</searchLink><br /><searchLink fieldCode="DE" term="%22Nutrition%22">Nutrition</searchLink><br /><searchLink fieldCode="DE" term="%22Comorbidity%22">Comorbidity</searchLink><br /><searchLink fieldCode="DE" term="%22C-reactive+protein%22">C-reactive protein</searchLink><br /><searchLink fieldCode="DE" term="%22Gastrointestinal+diseases%22">Gastrointestinal diseases</searchLink><br /><searchLink fieldCode="DE" term="%22Adolescence%22">Adolescence</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Objective: Avoidant/restrictive food intake disorder (ARFID) is common among populations with nutrition‐related medical conditions. Less is known about the medical comorbidity/complication frequencies in youth with ARFID. We evaluated the medical comorbidities and metabolic/nutritional markers among female and male youth with full/subthreshold ARFID across the weight spectrum compared with healthy controls (HC). Method: In youth with full/subthreshold ARFID (n = 100; 49% female) and HC (n = 58; 78% female), we assessed self‐reported medical comorbidities via clinician interview and explored abnormalities in metabolic (lipid panel and high‐sensitive C‐reactive protein [hs‐CRP]) and nutritional (25[OH] vitamin D, vitamin B12, and folate) markers. Results: Youth with ARFID, compared with HC, were over 10 times as likely to have self‐reported gastrointestinal conditions (37% vs. 3%; OR = 21.2; 95% CI = 6.2–112.1) and over two times as likely to have self‐reported immune‐mediated conditions (42% vs. 24%; OR = 2.3; 95% CI = 1.1–4.9). ARFID, compared with HC, had a four to five times higher frequency of elevated triglycerides (28% vs. 12%; OR = 4.0; 95% CI = 1.7–10.5) and hs‐CRP (17% vs. 4%; OR = 5.0; 95% CI = 1.4–27.0) levels. Discussion: Self‐reported gastrointestinal and certain immune comorbidities were common in ARFID, suggestive of possible bidirectional risk/maintenance factors. Elevated cardiovascular risk markers in ARFID may be a consequence of limited dietary variety marked by high carbohydrate and sugar intake. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of International Journal of Eating Disorders is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
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    Identifiers:
      – Type: doi
        Value: 10.1002/eat.24243
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      – Code: eng
        Text: English
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      – SubjectFull: Analysis of triglycerides
        Type: general
      – SubjectFull: Risk assessment
        Type: general
      – SubjectFull: Research funding
        Type: general
      – SubjectFull: T-test (Statistics)
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      – SubjectFull: Interviewing
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      – SubjectFull: Kruskal-Wallis Test
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      – SubjectFull: Fisher exact test
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      – SubjectFull: Cardiovascular diseases risk factors
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      – SubjectFull: Descriptive statistics
        Type: general
      – SubjectFull: Chi-squared test
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      – SubjectFull: Eating disorders
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      – SubjectFull: Odds ratio
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      – SubjectFull: Confidence intervals
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      – SubjectFull: Data analysis software
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      – SubjectFull: Biomarkers
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      – SubjectFull: Adolescence
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      – TitleFull: Medical Comorbidities, Nutritional Markers, and Cardiovascular Risk Markers in Youth With ARFID.
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