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The impact of voluntary wheel-running exercise on hippocampal neurogenesis and behaviours in response to nicotine cessation in rats.

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Title: The impact of voluntary wheel-running exercise on hippocampal neurogenesis and behaviours in response to nicotine cessation in rats.
Authors: Zaniewska, Magdalena (AUTHOR), Brygider, Sabina (AUTHOR), Majcher-Maślanka, Iwona (AUTHOR), Gawliński, Dawid (AUTHOR), Głowacka, Urszula (AUTHOR), Glińska, Sława (AUTHOR), Balcerzak, Łucja (AUTHOR)
Source: Psychopharmacology. Dec2024, Vol. 241 Issue 12, p2585-2607. 23p.
Subjects: Dentate gyrus, Drug-seeking behavior, Nicotine, Rats, Hippocampus (Brain), Developmental neurobiology
Abstract: Rationale: The literature indicates that nicotine exposure or its discontinuation impair adult hippocampal neurogenesis in rats, though the impact of exercise on this process remains unclear. We have previously shown that disturbances in the number of doublecortin (DCX, a marker of immature neurons)-positive (DCX+) cells in the dentate gyrus (DG) of the hippocampus during nicotine deprivation may contribute to a depression-like state in rats. Objectives: This study aimed to investigate the effect of running on hippocampal neurogenesis, depression-like symptoms, and drug-seeking behaviour during nicotine deprivation. Methods: The rats were subjected to nicotine (0.03 mg/kg/inf) self-administration via an increasing schedule of reinforcement. After 21 sessions, the animals entered a 14-day abstinence phase during which they were housed in either standard home cages without wheels, cages equipped with running wheels, or cages with locked wheels. Results: Wheel running increased the number of Ki-67+ and DCX+ cells in the DG of both nicotine-deprived and nicotine-naive rats. Wheel-running exercise evoked an antidepressant effect on abstinence Day 14 but had no effect on nicotine-seeking behaviour on abstinence Day 15 compared to rats with locked-wheel access. Conclusions: In summary, long-term wheel running positively affected the number of immature neurons in the hippocampus, which corresponded with an antidepressant response in nicotine-weaned rats. One possible mechanism underlying the positive effect of running on the affective state during nicotine cessation may be the reduction in deficits in DCX+ cells in the hippocampus. [ABSTRACT FROM AUTHOR]
Copyright of Psychopharmacology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: The impact of voluntary wheel-running exercise on hippocampal neurogenesis and behaviours in response to nicotine cessation in rats.
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  Data: <searchLink fieldCode="AR" term="%22Zaniewska%2C+Magdalena%22">Zaniewska, Magdalena</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Brygider%2C+Sabina%22">Brygider, Sabina</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Majcher-Maślanka%2C+Iwona%22">Majcher-Maślanka, Iwona</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Gawliński%2C+Dawid%22">Gawliński, Dawid</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Głowacka%2C+Urszula%22">Głowacka, Urszula</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Glińska%2C+Sława%22">Glińska, Sława</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Balcerzak%2C+Łucja%22">Balcerzak, Łucja</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Psychopharmacology%22">Psychopharmacology</searchLink>. Dec2024, Vol. 241 Issue 12, p2585-2607. 23p.
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  Data: <searchLink fieldCode="DE" term="%22Dentate+gyrus%22">Dentate gyrus</searchLink><br /><searchLink fieldCode="DE" term="%22Drug-seeking+behavior%22">Drug-seeking behavior</searchLink><br /><searchLink fieldCode="DE" term="%22Nicotine%22">Nicotine</searchLink><br /><searchLink fieldCode="DE" term="%22Rats%22">Rats</searchLink><br /><searchLink fieldCode="DE" term="%22Hippocampus+%28Brain%29%22">Hippocampus (Brain)</searchLink><br /><searchLink fieldCode="DE" term="%22Developmental+neurobiology%22">Developmental neurobiology</searchLink>
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  Data: Rationale: The literature indicates that nicotine exposure or its discontinuation impair adult hippocampal neurogenesis in rats, though the impact of exercise on this process remains unclear. We have previously shown that disturbances in the number of doublecortin (DCX, a marker of immature neurons)-positive (DCX+) cells in the dentate gyrus (DG) of the hippocampus during nicotine deprivation may contribute to a depression-like state in rats. Objectives: This study aimed to investigate the effect of running on hippocampal neurogenesis, depression-like symptoms, and drug-seeking behaviour during nicotine deprivation. Methods: The rats were subjected to nicotine (0.03 mg/kg/inf) self-administration via an increasing schedule of reinforcement. After 21 sessions, the animals entered a 14-day abstinence phase during which they were housed in either standard home cages without wheels, cages equipped with running wheels, or cages with locked wheels. Results: Wheel running increased the number of Ki-67+ and DCX+ cells in the DG of both nicotine-deprived and nicotine-naive rats. Wheel-running exercise evoked an antidepressant effect on abstinence Day 14 but had no effect on nicotine-seeking behaviour on abstinence Day 15 compared to rats with locked-wheel access. Conclusions: In summary, long-term wheel running positively affected the number of immature neurons in the hippocampus, which corresponded with an antidepressant response in nicotine-weaned rats. One possible mechanism underlying the positive effect of running on the affective state during nicotine cessation may be the reduction in deficits in DCX+ cells in the hippocampus. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Psychopharmacology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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              Text: Dec2024
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