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The correlation between the severity of paroxysmal sympathetic hyperactivity and plasma catecholamine levels in patients with severe traumatic brain injury.

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Title: The correlation between the severity of paroxysmal sympathetic hyperactivity and plasma catecholamine levels in patients with severe traumatic brain injury.
Authors: Bansal, Sonia, Chakrabarti, Dhritiman, Krishnakumar, Mathangi, P, Sundaravadivel, Shukla, Dhaval, Padmasri, Gorantla, Christopher, Rita, Sathyaprabha, T N
Source: Brain Injury. 2024, Vol. 38 Issue 14, p1212-1219. 8p.
Subjects: Statistical correlation, Research funding, Sex distribution, Sympathetic nervous system, Severity of illness index, Adrenaline, Age distribution, Glasgow Coma Scale, Descriptive statistics, Longitudinal method, Research, Case-control method, Noradrenaline, Brain injuries, Catecholamines, Length of stay in hospitals, Evaluation, Disease complications
Abstract: Background: There is limited literature investigating the catecholamine levels in patients with paroxysmal sympathetic hyperactivity (PSH) after traumatic brain injury (TBI). The primary objective of this study was to correlate the severity of PSH (assessed using the PSH-Assessment measure [AM]) with plasma catecholamine levels at a resting state. Methods: In this prospective case−control study, blood samples for epinephrine and norepinephrine estimation were obtained at rest on three consecutive days, only for 'cases' of PSH after severe TBI (s-TBI) and for control patients (matched for age, gender, and Glasgow coma scale [GCS]. Results: Twenty-seven patients with PSH and 16 controls were recruited. The median PSH-AM score was 20 and 9 in cases and controls, respectively. The epinephrine and norepinephrine levels at rest did not correlate with the severity of PSH assessed during PSH paroxysms (p = 0.949 and 0.975). Norepinephrine levels increased in PSH patients over the 3 consecutive days, once PSH was diagnosed (p = 0.022). The length of hospital stay was longer and the motor-GCS score was lower in PSH patients, with no differences in other outcomes between the groups. Conclusion: Catecholamine levels in the inter-paroxysmal interval cannot be correlated with PSH severity assessed during the paroxysms. However, the results of the study need to be confirmed by a larger sample size as the study is underpowered. [ABSTRACT FROM AUTHOR]
Copyright of Brain Injury is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: The correlation between the severity of paroxysmal sympathetic hyperactivity and plasma catecholamine levels in patients with severe traumatic brain injury.
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  Data: <searchLink fieldCode="JN" term="%22Brain+Injury%22">Brain Injury</searchLink>. 2024, Vol. 38 Issue 14, p1212-1219. 8p.
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  Data: Background: There is limited literature investigating the catecholamine levels in patients with paroxysmal sympathetic hyperactivity (PSH) after traumatic brain injury (TBI). The primary objective of this study was to correlate the severity of PSH (assessed using the PSH-Assessment measure [AM]) with plasma catecholamine levels at a resting state. Methods: In this prospective case−control study, blood samples for epinephrine and norepinephrine estimation were obtained at rest on three consecutive days, only for 'cases' of PSH after severe TBI (s-TBI) and for control patients (matched for age, gender, and Glasgow coma scale [GCS]. Results: Twenty-seven patients with PSH and 16 controls were recruited. The median PSH-AM score was 20 and 9 in cases and controls, respectively. The epinephrine and norepinephrine levels at rest did not correlate with the severity of PSH assessed during PSH paroxysms (p = 0.949 and 0.975). Norepinephrine levels increased in PSH patients over the 3 consecutive days, once PSH was diagnosed (p = 0.022). The length of hospital stay was longer and the motor-GCS score was lower in PSH patients, with no differences in other outcomes between the groups. Conclusion: Catecholamine levels in the inter-paroxysmal interval cannot be correlated with PSH severity assessed during the paroxysms. However, the results of the study need to be confirmed by a larger sample size as the study is underpowered. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Brain Injury is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
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      – Type: doi
        Value: 10.1080/02699052.2024.2380460
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      – Code: eng
        Text: English
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      Pagination:
        PageCount: 8
        StartPage: 1212
    Subjects:
      – SubjectFull: Statistical correlation
        Type: general
      – SubjectFull: Research funding
        Type: general
      – SubjectFull: Sex distribution
        Type: general
      – SubjectFull: Sympathetic nervous system
        Type: general
      – SubjectFull: Severity of illness index
        Type: general
      – SubjectFull: Adrenaline
        Type: general
      – SubjectFull: Age distribution
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      – SubjectFull: Glasgow Coma Scale
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      – SubjectFull: Descriptive statistics
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      – SubjectFull: Longitudinal method
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      – SubjectFull: Case-control method
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      – SubjectFull: Noradrenaline
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      – SubjectFull: Brain injuries
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      – SubjectFull: Catecholamines
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      – SubjectFull: Length of stay in hospitals
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              Text: 2024
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