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Plasminogen Activator Inhibitor‐1 in the Pathophysiology of Late Life Depression.

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Title: Plasminogen Activator Inhibitor‐1 in the Pathophysiology of Late Life Depression.
Authors: Métivier, L., Vivien, D., Goy, R., Agin, V., Bui, E., Benbrika, S.
Source: International Journal of Geriatric Psychiatry. Nov2024, Vol. 39 Issue 11, p1-14. 14p.
Subjects: Mental depression risk factors, Adipokines, Health status indicators, Cellular aging, Apoptosis, Sedentary lifestyles, Geriatric psychiatry, Insulin, Tissue plasminogen activator, Blood coagulation factors, Antidepressants, Gene expression, Protease inhibitors, Aging, Fibrinolysis, Psychological stress, Cytokines, Inflammation, Cushing's syndrome, Mental depression, Drug resistance, Biomarkers, Interleukins, Old age
Abstract: Introduction: Late life depression (LLD) is characterized by specific clinical features including a high frequency of vascular form and frequent antidepressant treatment resistance. The expression and functions of the serine protease inhibitor, Plasminogen Activator Inhibitor‐1 (PAI‐1) is known to be altered by aging, vascular damage, insulin levels associated with a sedentary lifestyle, chronic stress leading to hypercortisolemia, and inflammatory changes linked to stress responses. These phenomena would be implicated in LLD like vascular depression. This article thus aims to review the existing literature regarding the association between LLD and plasmatic levels of PAI‐1, a marker of hypofibrinolysis. We hypothesize that increased age would be associated with changes in PAI‐1 plasma level and function which influence LLD pathogenesis and its treatment. Results: Although a large number of studies on PAI‐1 changes in the elderly exist, studies about its implications in LLD are sparse. Despite heterogeneous findings regarding the direction of variation in plasmatic PAI‐1 levels among elderly participants with LLD, all studies demonstrated an association between PAI‐1 levels and current or remitted depressive symptoms. Moreover, disruptions in the concentrations of other biological markers influencing PAI‐1 expression, such as cytokines or adipokines, were also observed, notably an increase in the levels of interleukins 6 and 8. Discussion: LLD genesis appears to be influenced by PAI‐1 regulatory loops which are implicated in senescence or cell death. The resistance to antidepressant treatment appears to be linked to distinct biological profiles involving inflammatory and fibrinolytic factors. Taken together these data suggest that PAI‐1 pathway may be a promising target of treatment development efforts for LLD, and depression in general. [ABSTRACT FROM AUTHOR]
Copyright of International Journal of Geriatric Psychiatry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Plasminogen Activator Inhibitor‐1 in the Pathophysiology of Late Life Depression.
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  Data: <searchLink fieldCode="AR" term="%22Métivier%2C+L%2E%22">Métivier, L.</searchLink><br /><searchLink fieldCode="AR" term="%22Vivien%2C+D%2E%22">Vivien, D.</searchLink><br /><searchLink fieldCode="AR" term="%22Goy%2C+R%2E%22">Goy, R.</searchLink><br /><searchLink fieldCode="AR" term="%22Agin%2C+V%2E%22">Agin, V.</searchLink><br /><searchLink fieldCode="AR" term="%22Bui%2C+E%2E%22">Bui, E.</searchLink><br /><searchLink fieldCode="AR" term="%22Benbrika%2C+S%2E%22">Benbrika, S.</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22International+Journal+of+Geriatric+Psychiatry%22">International Journal of Geriatric Psychiatry</searchLink>. Nov2024, Vol. 39 Issue 11, p1-14. 14p.
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  Data: <searchLink fieldCode="DE" term="%22Mental+depression+risk+factors%22">Mental depression risk factors</searchLink><br /><searchLink fieldCode="DE" term="%22Adipokines%22">Adipokines</searchLink><br /><searchLink fieldCode="DE" term="%22Health+status+indicators%22">Health status indicators</searchLink><br /><searchLink fieldCode="DE" term="%22Cellular+aging%22">Cellular aging</searchLink><br /><searchLink fieldCode="DE" term="%22Apoptosis%22">Apoptosis</searchLink><br /><searchLink fieldCode="DE" term="%22Sedentary+lifestyles%22">Sedentary lifestyles</searchLink><br /><searchLink fieldCode="DE" term="%22Geriatric+psychiatry%22">Geriatric psychiatry</searchLink><br /><searchLink fieldCode="DE" term="%22Insulin%22">Insulin</searchLink><br /><searchLink fieldCode="DE" term="%22Tissue+plasminogen+activator%22">Tissue plasminogen activator</searchLink><br /><searchLink fieldCode="DE" term="%22Blood+coagulation+factors%22">Blood coagulation factors</searchLink><br /><searchLink fieldCode="DE" term="%22Antidepressants%22">Antidepressants</searchLink><br /><searchLink fieldCode="DE" term="%22Gene+expression%22">Gene expression</searchLink><br /><searchLink fieldCode="DE" term="%22Protease+inhibitors%22">Protease inhibitors</searchLink><br /><searchLink fieldCode="DE" term="%22Aging%22">Aging</searchLink><br /><searchLink fieldCode="DE" term="%22Fibrinolysis%22">Fibrinolysis</searchLink><br /><searchLink fieldCode="DE" term="%22Psychological+stress%22">Psychological stress</searchLink><br /><searchLink fieldCode="DE" term="%22Cytokines%22">Cytokines</searchLink><br /><searchLink fieldCode="DE" term="%22Inflammation%22">Inflammation</searchLink><br /><searchLink fieldCode="DE" term="%22Cushing's+syndrome%22">Cushing's syndrome</searchLink><br /><searchLink fieldCode="DE" term="%22Mental+depression%22">Mental depression</searchLink><br /><searchLink fieldCode="DE" term="%22Drug+resistance%22">Drug resistance</searchLink><br /><searchLink fieldCode="DE" term="%22Biomarkers%22">Biomarkers</searchLink><br /><searchLink fieldCode="DE" term="%22Interleukins%22">Interleukins</searchLink><br /><searchLink fieldCode="DE" term="%22Old+age%22">Old age</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Introduction: Late life depression (LLD) is characterized by specific clinical features including a high frequency of vascular form and frequent antidepressant treatment resistance. The expression and functions of the serine protease inhibitor, Plasminogen Activator Inhibitor‐1 (PAI‐1) is known to be altered by aging, vascular damage, insulin levels associated with a sedentary lifestyle, chronic stress leading to hypercortisolemia, and inflammatory changes linked to stress responses. These phenomena would be implicated in LLD like vascular depression. This article thus aims to review the existing literature regarding the association between LLD and plasmatic levels of PAI‐1, a marker of hypofibrinolysis. We hypothesize that increased age would be associated with changes in PAI‐1 plasma level and function which influence LLD pathogenesis and its treatment. Results: Although a large number of studies on PAI‐1 changes in the elderly exist, studies about its implications in LLD are sparse. Despite heterogeneous findings regarding the direction of variation in plasmatic PAI‐1 levels among elderly participants with LLD, all studies demonstrated an association between PAI‐1 levels and current or remitted depressive symptoms. Moreover, disruptions in the concentrations of other biological markers influencing PAI‐1 expression, such as cytokines or adipokines, were also observed, notably an increase in the levels of interleukins 6 and 8. Discussion: LLD genesis appears to be influenced by PAI‐1 regulatory loops which are implicated in senescence or cell death. The resistance to antidepressant treatment appears to be linked to distinct biological profiles involving inflammatory and fibrinolytic factors. Taken together these data suggest that PAI‐1 pathway may be a promising target of treatment development efforts for LLD, and depression in general. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of International Journal of Geriatric Psychiatry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=181108156
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      – Type: doi
        Value: 10.1002/gps.70015
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      – Code: eng
        Text: English
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      Pagination:
        PageCount: 14
        StartPage: 1
    Subjects:
      – SubjectFull: Mental depression risk factors
        Type: general
      – SubjectFull: Adipokines
        Type: general
      – SubjectFull: Health status indicators
        Type: general
      – SubjectFull: Cellular aging
        Type: general
      – SubjectFull: Apoptosis
        Type: general
      – SubjectFull: Sedentary lifestyles
        Type: general
      – SubjectFull: Geriatric psychiatry
        Type: general
      – SubjectFull: Insulin
        Type: general
      – SubjectFull: Tissue plasminogen activator
        Type: general
      – SubjectFull: Blood coagulation factors
        Type: general
      – SubjectFull: Antidepressants
        Type: general
      – SubjectFull: Gene expression
        Type: general
      – SubjectFull: Protease inhibitors
        Type: general
      – SubjectFull: Aging
        Type: general
      – SubjectFull: Fibrinolysis
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      – SubjectFull: Psychological stress
        Type: general
      – SubjectFull: Cytokines
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      – SubjectFull: Inflammation
        Type: general
      – SubjectFull: Cushing's syndrome
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      – SubjectFull: Mental depression
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      – SubjectFull: Drug resistance
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      – SubjectFull: Interleukins
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      – SubjectFull: Old age
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      – TitleFull: Plasminogen Activator Inhibitor‐1 in the Pathophysiology of Late Life Depression.
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              M: 11
              Text: Nov2024
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              Y: 2024
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