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The influence of stereotaxic lesions of claustrum on motor movements and behaviour in rats.

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Title: The influence of stereotaxic lesions of claustrum on motor movements and behaviour in rats.
Authors: Seçen, Ahmet Eren (AUTHOR), Akçalı, Didem Tuba (AUTHOR), Dileköz, Ergin (AUTHOR), Çağıl, Emin (AUTHOR), Divanlıoğlu, Denizhan (AUTHOR), Öcal, Özgür (AUTHOR), Bolay Belen, Hayrunnisa (AUTHOR)
Source: Somatosensory & Motor Research. Dec2024, Vol. 41 Issue 4, p264-271. 8p.
Subjects: Constant current sources, Maze tests, Sound recordings, Rats, Control groups
Abstract: Background: This study aimed to expand our existing information on changes in the regulation of motor movement and behaviour by investigating the effects of unilateral and bilateral lesions on the claustrum (CL). Material and Methods: 36 Wistar Albino adult male rats were randomly divided into six groups. An electrical lesion was created with a constant current source in the unilateral and bilateral anterior clastrum using a stereotaxic frame in rats. The lesioned groups and the control group underwent an automatic behaviour recording device such as mobilisation, freezing, eating, drinking behaviour, grooming, turning, etc. behaviour was recorded and analysed. Simultaneously, ultrasonic sounds in rats were examined with ultrasonic sound recording program. Anxiety was then reassessed with the elevated plus maze test. Data were compared with the control group. Rats were eventually sacrificed and the brain tissue was post-fixed. Histochemical examination was done and lesions' existence was confirmed. Results: In this study, lesions of ventral of CL can cause increase in spontaneous behaviours such as freezing and rearing. And, it has been shown to cause a statistically significant change. In addition to the behavioural changes, right CL lesions have caused a significant increase in drinking behaviour associated with increased anxiety. All operated groups showed a significant decrease in clockwise and counterclockwise rotation movements. Conclusion: Experimental results show that CL lesions influence spontaneous behaviour which indicate the need for new studies to understand the role of CL in anxiety-depression. [ABSTRACT FROM AUTHOR]
Copyright of Somatosensory & Motor Research is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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Items – Name: Title
  Label: Title
  Group: Ti
  Data: The influence of stereotaxic lesions of claustrum on motor movements and behaviour in rats.
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  Data: <searchLink fieldCode="AR" term="%22Seçen%2C+Ahmet+Eren%22">Seçen, Ahmet Eren</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Akçalı%2C+Didem+Tuba%22">Akçalı, Didem Tuba</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Dileköz%2C+Ergin%22">Dileköz, Ergin</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Çağıl%2C+Emin%22">Çağıl, Emin</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Divanlıoğlu%2C+Denizhan%22">Divanlıoğlu, Denizhan</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Öcal%2C+Özgür%22">Öcal, Özgür</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Bolay+Belen%2C+Hayrunnisa%22">Bolay Belen, Hayrunnisa</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Somatosensory+%26+Motor+Research%22">Somatosensory & Motor Research</searchLink>. Dec2024, Vol. 41 Issue 4, p264-271. 8p.
– Name: Subject
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  Data: <searchLink fieldCode="DE" term="%22Constant+current+sources%22">Constant current sources</searchLink><br /><searchLink fieldCode="DE" term="%22Maze+tests%22">Maze tests</searchLink><br /><searchLink fieldCode="DE" term="%22Sound+recordings%22">Sound recordings</searchLink><br /><searchLink fieldCode="DE" term="%22Rats%22">Rats</searchLink><br /><searchLink fieldCode="DE" term="%22Control+groups%22">Control groups</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Background: This study aimed to expand our existing information on changes in the regulation of motor movement and behaviour by investigating the effects of unilateral and bilateral lesions on the claustrum (CL). Material and Methods: 36 Wistar Albino adult male rats were randomly divided into six groups. An electrical lesion was created with a constant current source in the unilateral and bilateral anterior clastrum using a stereotaxic frame in rats. The lesioned groups and the control group underwent an automatic behaviour recording device such as mobilisation, freezing, eating, drinking behaviour, grooming, turning, etc. behaviour was recorded and analysed. Simultaneously, ultrasonic sounds in rats were examined with ultrasonic sound recording program. Anxiety was then reassessed with the elevated plus maze test. Data were compared with the control group. Rats were eventually sacrificed and the brain tissue was post-fixed. Histochemical examination was done and lesions' existence was confirmed. Results: In this study, lesions of ventral of CL can cause increase in spontaneous behaviours such as freezing and rearing. And, it has been shown to cause a statistically significant change. In addition to the behavioural changes, right CL lesions have caused a significant increase in drinking behaviour associated with increased anxiety. All operated groups showed a significant decrease in clockwise and counterclockwise rotation movements. Conclusion: Experimental results show that CL lesions influence spontaneous behaviour which indicate the need for new studies to understand the role of CL in anxiety-depression. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Somatosensory & Motor Research is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1080/08990220.2023.2280563
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        Text: English
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      – SubjectFull: Maze tests
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      – SubjectFull: Sound recordings
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            NameFull: Seçen, Ahmet Eren
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              M: 12
              Text: Dec2024
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              Y: 2024
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