View in EDS HTML Full Text PDF Full Text

Mirtazapine in pregnancy and lactation: A systematic review of adverse outcomes.

Saved in:
Bibliographic Details
Title: Mirtazapine in pregnancy and lactation: A systematic review of adverse outcomes.
Authors: Ostenfeld, Anne (AUTHOR), Lyngholm, Sofie (AUTHOR), Christensen, Sarah Emilie (AUTHOR), Petersen, Tonny Studsgaard (AUTHOR), Andersen, Jon Trærup (AUTHOR), Westergaard, Hanne Brix (AUTHOR), Pedersen, Lars Henning (AUTHOR), Løkkegaard, Ellen Christine Leth (AUTHOR)
Source: Acta Psychiatrica Scandinavica. Jan2025, Vol. 151 Issue 1, p6-32. 27p.
Subjects: Miscarriage, Pregnancy outcomes, Mirtazapine, Human abnormalities, Lactation
Abstract: Introduction: Peripartum depression is common and treatment with mirtazapine may be indicated. However, evidence on its safety in pregnancy and lactation is fragmented. The objective of this systematic review was to evaluate the literature on the safety of mirtazapine in pregnancy and lactation. Methods: PubMed, Embase, Medline, PsycInfo, and clinicaltrials.gov were searched for 'antidepressants' or 'mirtazapine' in combination with 'pregnancy', 'lactation' or 'offspring'. No restrictions on type of study were applied and selection was performed by two independent reviewers using Covidence. Two reviewers extracted data and performed risk of bias assessment and evidence synthesis was performed for each outcome individually. The protocol was registered at PROSPERO (registration number CRD42021275127). Results: The initial search yielded 15,380 articles after removal of duplicates. After screening based on title and abstract, 431 articles remained for full text review. Of these, 41 studies were included (15 cohort studies, one case–control study, 11 case series, and 14 case reports). In most studies, the outcomes in mirtazapine‐exposed pregnancies were comparable to controls. However, results on congenital malformations and spontaneous abortion were conflicting. Neonatal adaptation syndrome was reported after mirtazapine exposure in late pregnancy. Data on mirtazapine exposure during lactation were scarce. Conclusions: We identified no substantial evidence indicating that mirtazapine exposure is associated with adverse outcomes in pregnancy or in offspring, other than neonatal adaptation syndrome. However, overall quality of evidence was low, and results on congenital malformations and spontaneous abortions were conflicting. Data on mirtazapine exposure through breastfeeding were limited and did not allow for conclusions. [ABSTRACT FROM AUTHOR]
Copyright of Acta Psychiatrica Scandinavica is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
Full text is not displayed to guests.
FullText Links:
  – Type: pdflink
Text:
  Availability: 1
Header DbId: pbh
DbLabel: Psychology and Behavioral Sciences Collection
An: 181226894
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Mirtazapine in pregnancy and lactation: A systematic review of adverse outcomes.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Ostenfeld%2C+Anne%22">Ostenfeld, Anne</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lyngholm%2C+Sofie%22">Lyngholm, Sofie</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Christensen%2C+Sarah+Emilie%22">Christensen, Sarah Emilie</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Petersen%2C+Tonny+Studsgaard%22">Petersen, Tonny Studsgaard</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Andersen%2C+Jon+Trærup%22">Andersen, Jon Trærup</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Westergaard%2C+Hanne+Brix%22">Westergaard, Hanne Brix</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Pedersen%2C+Lars+Henning%22">Pedersen, Lars Henning</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Løkkegaard%2C+Ellen+Christine+Leth%22">Løkkegaard, Ellen Christine Leth</searchLink> (AUTHOR)
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22Acta+Psychiatrica+Scandinavica%22">Acta Psychiatrica Scandinavica</searchLink>. Jan2025, Vol. 151 Issue 1, p6-32. 27p.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Miscarriage%22">Miscarriage</searchLink><br /><searchLink fieldCode="DE" term="%22Pregnancy+outcomes%22">Pregnancy outcomes</searchLink><br /><searchLink fieldCode="DE" term="%22Mirtazapine%22">Mirtazapine</searchLink><br /><searchLink fieldCode="DE" term="%22Human+abnormalities%22">Human abnormalities</searchLink><br /><searchLink fieldCode="DE" term="%22Lactation%22">Lactation</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Introduction: Peripartum depression is common and treatment with mirtazapine may be indicated. However, evidence on its safety in pregnancy and lactation is fragmented. The objective of this systematic review was to evaluate the literature on the safety of mirtazapine in pregnancy and lactation. Methods: PubMed, Embase, Medline, PsycInfo, and clinicaltrials.gov were searched for 'antidepressants' or 'mirtazapine' in combination with 'pregnancy', 'lactation' or 'offspring'. No restrictions on type of study were applied and selection was performed by two independent reviewers using Covidence. Two reviewers extracted data and performed risk of bias assessment and evidence synthesis was performed for each outcome individually. The protocol was registered at PROSPERO (registration number CRD42021275127). Results: The initial search yielded 15,380 articles after removal of duplicates. After screening based on title and abstract, 431 articles remained for full text review. Of these, 41 studies were included (15 cohort studies, one case–control study, 11 case series, and 14 case reports). In most studies, the outcomes in mirtazapine‐exposed pregnancies were comparable to controls. However, results on congenital malformations and spontaneous abortion were conflicting. Neonatal adaptation syndrome was reported after mirtazapine exposure in late pregnancy. Data on mirtazapine exposure during lactation were scarce. Conclusions: We identified no substantial evidence indicating that mirtazapine exposure is associated with adverse outcomes in pregnancy or in offspring, other than neonatal adaptation syndrome. However, overall quality of evidence was low, and results on congenital malformations and spontaneous abortions were conflicting. Data on mirtazapine exposure through breastfeeding were limited and did not allow for conclusions. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Acta Psychiatrica Scandinavica is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=181226894
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1111/acps.13749
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 27
        StartPage: 6
    Subjects:
      – SubjectFull: Miscarriage
        Type: general
      – SubjectFull: Pregnancy outcomes
        Type: general
      – SubjectFull: Mirtazapine
        Type: general
      – SubjectFull: Human abnormalities
        Type: general
      – SubjectFull: Lactation
        Type: general
    Titles:
      – TitleFull: Mirtazapine in pregnancy and lactation: A systematic review of adverse outcomes.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Ostenfeld, Anne
      – PersonEntity:
          Name:
            NameFull: Lyngholm, Sofie
      – PersonEntity:
          Name:
            NameFull: Christensen, Sarah Emilie
      – PersonEntity:
          Name:
            NameFull: Petersen, Tonny Studsgaard
      – PersonEntity:
          Name:
            NameFull: Andersen, Jon Trærup
      – PersonEntity:
          Name:
            NameFull: Westergaard, Hanne Brix
      – PersonEntity:
          Name:
            NameFull: Pedersen, Lars Henning
      – PersonEntity:
          Name:
            NameFull: Løkkegaard, Ellen Christine Leth
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 01
              Text: Jan2025
              Type: published
              Y: 2025
          Identifiers:
            – Type: issn-print
              Value: 0001690X
          Numbering:
            – Type: volume
              Value: 151
            – Type: issue
              Value: 1
          Titles:
            – TitleFull: Acta Psychiatrica Scandinavica
              Type: main
ResultId 1