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Differential temporal decline of cerebral oxytocin and μ‐opioid receptor density during the aging process in mice.

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Title: Differential temporal decline of cerebral oxytocin and μ‐opioid receptor density during the aging process in mice.
Authors: Effah, Felix (AUTHOR), Nidadavolu, Prakash (AUTHOR), de Gusmão Taveiros Silva, Nívea Karla (AUTHOR), Wojtowicz, Milosz (AUTHOR), Camarini, Rosana (AUTHOR), Zimmer, Andreas (AUTHOR), Bailey, Alexis (AUTHOR)
Source: European Journal of Neuroscience. Dec2024, Vol. 60 Issue 11, p6686-6703. 18p.
Subjects: Olfactory cortex, Oxytocin receptors, Middle age, Nucleus accumbens, Old age, Opioid receptors
Abstract: Aging is often associated with changes in social, sexual, emotional and pain functioning, as well as with the increased prevalence of certain psychopathologies. However, the neurodevelopmental basis underpinning these age‐related changes remains to be determined. Considering the key roles of oxytocin (OTR) and μ‐opioid (MOPr) receptor systems in regulating social, sexual, pain, reward and emotional processing, it seems plausible that they are also implicated in age‐related behavioural alterations. Although the ontogeny of both receptors has been well characterized in rodent brains from early development till adulthood, little is known concerning the neuroadaptations occurring from middle age to old age. Therefore, we mapped the neuroadaptations in OTR and MOPr in the brains of mice at those developmental endpoints. Quantitative OTR and MOPr autoradiographic binding was carried out in the brains of male mice at 2, 6, 9, 12 and 18 months of age. A significant whole brain decline in OTR density was detected between 2 and 6 months of age, with no additional decline thereafter. Interestingly, for MOPrs, the decline in density was not detected until 9 months of age. Region‐specific age‐related decline in OTR density was concentrated in the lateral anterior olfactory nuclei (AOL) and, for MOPr, in the AOL and the nucleus accumbens. Identifying the tipping point of these age‐related variations in both receptors may assist with our understanding of the neurobiology underlining age‐related changes in social, pain and emotional functioning/processing. It may also help us target interventions to specific developmental windows to abrogate certain age‐related psychopathologies. [ABSTRACT FROM AUTHOR]
Copyright of European Journal of Neuroscience is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Differential temporal decline of cerebral oxytocin and μ‐opioid receptor density during the aging process in mice.
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  Data: <searchLink fieldCode="AR" term="%22Effah%2C+Felix%22">Effah, Felix</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Nidadavolu%2C+Prakash%22">Nidadavolu, Prakash</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22de+Gusmão+Taveiros+Silva%2C+Nívea+Karla%22">de Gusmão Taveiros Silva, Nívea Karla</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Wojtowicz%2C+Milosz%22">Wojtowicz, Milosz</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Camarini%2C+Rosana%22">Camarini, Rosana</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zimmer%2C+Andreas%22">Zimmer, Andreas</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Bailey%2C+Alexis%22">Bailey, Alexis</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22European+Journal+of+Neuroscience%22">European Journal of Neuroscience</searchLink>. Dec2024, Vol. 60 Issue 11, p6686-6703. 18p.
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  Data: <searchLink fieldCode="DE" term="%22Olfactory+cortex%22">Olfactory cortex</searchLink><br /><searchLink fieldCode="DE" term="%22Oxytocin+receptors%22">Oxytocin receptors</searchLink><br /><searchLink fieldCode="DE" term="%22Middle+age%22">Middle age</searchLink><br /><searchLink fieldCode="DE" term="%22Nucleus+accumbens%22">Nucleus accumbens</searchLink><br /><searchLink fieldCode="DE" term="%22Old+age%22">Old age</searchLink><br /><searchLink fieldCode="DE" term="%22Opioid+receptors%22">Opioid receptors</searchLink>
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  Data: Aging is often associated with changes in social, sexual, emotional and pain functioning, as well as with the increased prevalence of certain psychopathologies. However, the neurodevelopmental basis underpinning these age‐related changes remains to be determined. Considering the key roles of oxytocin (OTR) and μ‐opioid (MOPr) receptor systems in regulating social, sexual, pain, reward and emotional processing, it seems plausible that they are also implicated in age‐related behavioural alterations. Although the ontogeny of both receptors has been well characterized in rodent brains from early development till adulthood, little is known concerning the neuroadaptations occurring from middle age to old age. Therefore, we mapped the neuroadaptations in OTR and MOPr in the brains of mice at those developmental endpoints. Quantitative OTR and MOPr autoradiographic binding was carried out in the brains of male mice at 2, 6, 9, 12 and 18 months of age. A significant whole brain decline in OTR density was detected between 2 and 6 months of age, with no additional decline thereafter. Interestingly, for MOPrs, the decline in density was not detected until 9 months of age. Region‐specific age‐related decline in OTR density was concentrated in the lateral anterior olfactory nuclei (AOL) and, for MOPr, in the AOL and the nucleus accumbens. Identifying the tipping point of these age‐related variations in both receptors may assist with our understanding of the neurobiology underlining age‐related changes in social, pain and emotional functioning/processing. It may also help us target interventions to specific developmental windows to abrogate certain age‐related psychopathologies. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of European Journal of Neuroscience is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1111/ejn.16578
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        Text: English
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        Type: general
      – SubjectFull: Oxytocin receptors
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      – SubjectFull: Middle age
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      – SubjectFull: Nucleus accumbens
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      – SubjectFull: Old age
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      – SubjectFull: Opioid receptors
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      – TitleFull: Differential temporal decline of cerebral oxytocin and μ‐opioid receptor density during the aging process in mice.
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            NameFull: de Gusmão Taveiros Silva, Nívea Karla
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              M: 12
              Text: Dec2024
              Type: published
              Y: 2024
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