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Impact of psilocybin on cognitive function: A systematic review.

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Title: Impact of psilocybin on cognitive function: A systematic review.
Authors: Meshkat, Shakila (AUTHOR), Tello‐Gerez, Triana Juliana (AUTHOR), Gholaminezhad, Fatemeh (AUTHOR), Dunkley, Benjamin T. (AUTHOR), Reichelt, Amy C. (AUTHOR), Erritzoe, David (AUTHOR), Vermetten, Eric (AUTHOR), Zhang, Yanbo (AUTHOR), Greenshaw, Andrew (AUTHOR), Burback, Lisa (AUTHOR), Winkler, Olga (AUTHOR), Jetly, Rakesh (AUTHOR), Mayo, Leah M. (AUTHOR), Bhat, Venkat (AUTHOR)
Source: Psychiatry & Clinical Neurosciences. Dec2024, Vol. 78 Issue 12, p744-764. 21p.
Subjects: Cognitive processing speed, Cognitive flexibility, Nootropic agents, Cognition, Cognitive ability
Abstract: Psilocybin is a classic psychedelic with demonstrated preliminary clinical efficacy in a range of psychiatric disorders. Evaluating the impact of psilocybin on cognitive function is essential to unravel its potential benefits and risks. In this systematic review, we assessed psilocybin's effect on cognitive function through a comprehensive search of electronic databases from inception to January 2024, identifying 20 articles involving 2,959 participants. While 85% of studies were conducted in healthy volunteers, most of these studies (85%) used macrodoses, ranging from 45 μg/kg to 30 mg/70 kg. Various cognitive aspects were evaluated and yielded mixed results. Global cognitive function, and processing speed remained mostly unchanged in healthy individuals; However, a limited number of studies reported improvements in certain areas such as sustained attention, working memory, and executive function especially in patients with treatment‐resistant depression (TRD). Emotional processing was positively modified, particularly in TRD patients. Psilocybin was observed to enhance emotional empathy without significantly altering cognitive empathy and social cognition. Cognitive flexibility and creative cognition were noted to initially decline but could potentially improve over time. Additionally, with respect to learning and memory skills, psilocybin showed promise in improving specific memory types such as semantic associations and associative learning, while its effects on episodic and verbal memory have been less pronounced compared to other cognitive enhancers. The observed mixed findings underscore the complexity of psilocybin's cognitive influence. Further research is essential to provide a clearer understanding of psilocybin's impact on cognitive domains and to guide the development of safe and effective interventions. [ABSTRACT FROM AUTHOR]
Copyright of Psychiatry & Clinical Neurosciences is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Impact of psilocybin on cognitive function: A systematic review.
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  Data: <searchLink fieldCode="AR" term="%22Meshkat%2C+Shakila%22">Meshkat, Shakila</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Tello‐Gerez%2C+Triana+Juliana%22">Tello‐Gerez, Triana Juliana</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Gholaminezhad%2C+Fatemeh%22">Gholaminezhad, Fatemeh</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Dunkley%2C+Benjamin+T%2E%22">Dunkley, Benjamin T.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Reichelt%2C+Amy+C%2E%22">Reichelt, Amy C.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Erritzoe%2C+David%22">Erritzoe, David</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Vermetten%2C+Eric%22">Vermetten, Eric</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zhang%2C+Yanbo%22">Zhang, Yanbo</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Greenshaw%2C+Andrew%22">Greenshaw, Andrew</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Burback%2C+Lisa%22">Burback, Lisa</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Winkler%2C+Olga%22">Winkler, Olga</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Jetly%2C+Rakesh%22">Jetly, Rakesh</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Mayo%2C+Leah+M%2E%22">Mayo, Leah M.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Bhat%2C+Venkat%22">Bhat, Venkat</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Psychiatry+%26+Clinical+Neurosciences%22">Psychiatry & Clinical Neurosciences</searchLink>. Dec2024, Vol. 78 Issue 12, p744-764. 21p.
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  Data: <searchLink fieldCode="DE" term="%22Cognitive+processing+speed%22">Cognitive processing speed</searchLink><br /><searchLink fieldCode="DE" term="%22Cognitive+flexibility%22">Cognitive flexibility</searchLink><br /><searchLink fieldCode="DE" term="%22Nootropic+agents%22">Nootropic agents</searchLink><br /><searchLink fieldCode="DE" term="%22Cognition%22">Cognition</searchLink><br /><searchLink fieldCode="DE" term="%22Cognitive+ability%22">Cognitive ability</searchLink>
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  Data: Psilocybin is a classic psychedelic with demonstrated preliminary clinical efficacy in a range of psychiatric disorders. Evaluating the impact of psilocybin on cognitive function is essential to unravel its potential benefits and risks. In this systematic review, we assessed psilocybin's effect on cognitive function through a comprehensive search of electronic databases from inception to January 2024, identifying 20 articles involving 2,959 participants. While 85% of studies were conducted in healthy volunteers, most of these studies (85%) used macrodoses, ranging from 45 μg/kg to 30 mg/70 kg. Various cognitive aspects were evaluated and yielded mixed results. Global cognitive function, and processing speed remained mostly unchanged in healthy individuals; However, a limited number of studies reported improvements in certain areas such as sustained attention, working memory, and executive function especially in patients with treatment‐resistant depression (TRD). Emotional processing was positively modified, particularly in TRD patients. Psilocybin was observed to enhance emotional empathy without significantly altering cognitive empathy and social cognition. Cognitive flexibility and creative cognition were noted to initially decline but could potentially improve over time. Additionally, with respect to learning and memory skills, psilocybin showed promise in improving specific memory types such as semantic associations and associative learning, while its effects on episodic and verbal memory have been less pronounced compared to other cognitive enhancers. The observed mixed findings underscore the complexity of psilocybin's cognitive influence. Further research is essential to provide a clearer understanding of psilocybin's impact on cognitive domains and to guide the development of safe and effective interventions. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Psychiatry & Clinical Neurosciences is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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