View in EDS HTML Full Text PDF Full Text

Titin Antibody Is Linked to Increased Hospitalization Rates in Nonthymoma Myasthenia Gravis in Central China.

Saved in:
Bibliographic Details
Title: Titin Antibody Is Linked to Increased Hospitalization Rates in Nonthymoma Myasthenia Gravis in Central China.
Authors: Zhen, Lulu (AUTHOR), Zhao, Xue (AUTHOR), Wu, Jinru (AUTHOR), Zhang, Yingna (AUTHOR), Shang, Haodong (AUTHOR), Shen, Xinru (AUTHOR), Chen, Shufan (AUTHOR), Zhu, Xiaoyan (AUTHOR), Liu, Hanbin (AUTHOR), Zhang, Jing (AUTHOR), Yang, Junhong (AUTHOR), Fang, Hua (AUTHOR), Zhang, Yunke (AUTHOR), Zhang, Qingyong (AUTHOR), Cui, Xinzheng (AUTHOR), Lv, Jie (AUTHOR), Gao, Feng (AUTHOR), Colosimo, Carlo (AUTHOR)
Source: Acta Neurologica Scandinavica. 11/19/2024, Vol. 2024, p1-8. 8p.
Subjects: Myasthenia gravis, Logistic regression analysis, Connectin, Hospital admission & discharge, Immunoglobulins
Abstract: Insufficient evidence exists to assess the effect of titin antibodies on nonthymoma myasthenia gravis (MG) treatment and prognosis. We analyzed whether titin antibody‐positive patients with nonthymoma MG (non‐TMG) have a higher frequency of hospitalization than those who are titin antibody‐negative. We retrospectively analyzed patient data from January 2017 to July 2022 obtained from an institutional databank. We compared the clinical characteristics, treatment regimens, and MG‐related annual hospitalization rate between titin antibody‐positive (Titin+ group) and titin antibody‐negative (Titin− group) patients with non‐TMG. Multivariate logistic regression was employed to examine the factors associated with multiple hospital admissions (≥ 2). Finally, 170 patients with non‐TMG were included, of whom 67 (39.4%) were Titin+ and 103 (60.6%) were Titin−. Compared with the Titin− group, the Titin+ group exhibited a notably higher annual hospitalization rate (p = 0.011). Multivariate logistic regression analysis revealed that titin antibody positivity was significantly associated with multiple hospitalizations. The optimal cutoff value for titin antibody levels related to multiple hospitalizations was 3.085. In patients with non‐TMG, titin antibodies were associated with more frequent hospitalizations. For these patients, especially those with titers ≥ 3.085, close monitoring of clinical symptom changes may reduce relapse. [ABSTRACT FROM AUTHOR]
Copyright of Acta Neurologica Scandinavica is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
Full text is not displayed to guests.
FullText Links:
  – Type: pdflink
Text:
  Availability: 1
Header DbId: pbh
DbLabel: Psychology and Behavioral Sciences Collection
An: 181438815
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Titin Antibody Is Linked to Increased Hospitalization Rates in Nonthymoma Myasthenia Gravis in Central China.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Zhen%2C+Lulu%22">Zhen, Lulu</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zhao%2C+Xue%22">Zhao, Xue</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Wu%2C+Jinru%22">Wu, Jinru</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zhang%2C+Yingna%22">Zhang, Yingna</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Shang%2C+Haodong%22">Shang, Haodong</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Shen%2C+Xinru%22">Shen, Xinru</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Chen%2C+Shufan%22">Chen, Shufan</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zhu%2C+Xiaoyan%22">Zhu, Xiaoyan</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Liu%2C+Hanbin%22">Liu, Hanbin</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zhang%2C+Jing%22">Zhang, Jing</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Yang%2C+Junhong%22">Yang, Junhong</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Fang%2C+Hua%22">Fang, Hua</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zhang%2C+Yunke%22">Zhang, Yunke</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zhang%2C+Qingyong%22">Zhang, Qingyong</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Cui%2C+Xinzheng%22">Cui, Xinzheng</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lv%2C+Jie%22">Lv, Jie</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Gao%2C+Feng%22">Gao, Feng</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Colosimo%2C+Carlo%22">Colosimo, Carlo</searchLink> (AUTHOR)
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22Acta+Neurologica+Scandinavica%22">Acta Neurologica Scandinavica</searchLink>. 11/19/2024, Vol. 2024, p1-8. 8p.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Myasthenia+gravis%22">Myasthenia gravis</searchLink><br /><searchLink fieldCode="DE" term="%22Logistic+regression+analysis%22">Logistic regression analysis</searchLink><br /><searchLink fieldCode="DE" term="%22Connectin%22">Connectin</searchLink><br /><searchLink fieldCode="DE" term="%22Hospital+admission+%26+discharge%22">Hospital admission & discharge</searchLink><br /><searchLink fieldCode="DE" term="%22Immunoglobulins%22">Immunoglobulins</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Insufficient evidence exists to assess the effect of titin antibodies on nonthymoma myasthenia gravis (MG) treatment and prognosis. We analyzed whether titin antibody‐positive patients with nonthymoma MG (non‐TMG) have a higher frequency of hospitalization than those who are titin antibody‐negative. We retrospectively analyzed patient data from January 2017 to July 2022 obtained from an institutional databank. We compared the clinical characteristics, treatment regimens, and MG‐related annual hospitalization rate between titin antibody‐positive (Titin+ group) and titin antibody‐negative (Titin− group) patients with non‐TMG. Multivariate logistic regression was employed to examine the factors associated with multiple hospital admissions (≥ 2). Finally, 170 patients with non‐TMG were included, of whom 67 (39.4%) were Titin+ and 103 (60.6%) were Titin−. Compared with the Titin− group, the Titin+ group exhibited a notably higher annual hospitalization rate (p = 0.011). Multivariate logistic regression analysis revealed that titin antibody positivity was significantly associated with multiple hospitalizations. The optimal cutoff value for titin antibody levels related to multiple hospitalizations was 3.085. In patients with non‐TMG, titin antibodies were associated with more frequent hospitalizations. For these patients, especially those with titers ≥ 3.085, close monitoring of clinical symptom changes may reduce relapse. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Acta Neurologica Scandinavica is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=181438815
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1155/ane/6343332
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 8
        StartPage: 1
    Subjects:
      – SubjectFull: Myasthenia gravis
        Type: general
      – SubjectFull: Logistic regression analysis
        Type: general
      – SubjectFull: Connectin
        Type: general
      – SubjectFull: Hospital admission & discharge
        Type: general
      – SubjectFull: Immunoglobulins
        Type: general
    Titles:
      – TitleFull: Titin Antibody Is Linked to Increased Hospitalization Rates in Nonthymoma Myasthenia Gravis in Central China.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Zhen, Lulu
      – PersonEntity:
          Name:
            NameFull: Zhao, Xue
      – PersonEntity:
          Name:
            NameFull: Wu, Jinru
      – PersonEntity:
          Name:
            NameFull: Zhang, Yingna
      – PersonEntity:
          Name:
            NameFull: Shang, Haodong
      – PersonEntity:
          Name:
            NameFull: Shen, Xinru
      – PersonEntity:
          Name:
            NameFull: Chen, Shufan
      – PersonEntity:
          Name:
            NameFull: Zhu, Xiaoyan
      – PersonEntity:
          Name:
            NameFull: Liu, Hanbin
      – PersonEntity:
          Name:
            NameFull: Zhang, Jing
      – PersonEntity:
          Name:
            NameFull: Yang, Junhong
      – PersonEntity:
          Name:
            NameFull: Fang, Hua
      – PersonEntity:
          Name:
            NameFull: Zhang, Yunke
      – PersonEntity:
          Name:
            NameFull: Zhang, Qingyong
      – PersonEntity:
          Name:
            NameFull: Cui, Xinzheng
      – PersonEntity:
          Name:
            NameFull: Lv, Jie
      – PersonEntity:
          Name:
            NameFull: Gao, Feng
      – PersonEntity:
          Name:
            NameFull: Colosimo, Carlo
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 19
              M: 11
              Text: 11/19/2024
              Type: published
              Y: 2024
          Identifiers:
            – Type: issn-print
              Value: 00016314
          Numbering:
            – Type: volume
              Value: 2024
          Titles:
            – TitleFull: Acta Neurologica Scandinavica
              Type: main
ResultId 1