Programming tissue-sensing T cells that deliver therapies to the brain.

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Bibliographic Details
Title:	Programming tissue-sensing T cells that deliver therapies to the brain.
Authors:	Simic, Milos S., Watchmaker, Payal B., Gupta, Sasha, Yuan Wang, Sagan, Sharon A., Duecker, Jason, Shepherd, Chanelle, Diebold, David, Pineo-Cavanaugh, Psalm, Haegelin, Jeffrey, Zhu, Robert, Ben Ng, Wei Yu, Tonai, Yurie, Cardarelli, Lia, Reddy, Nishith R., Sidhu, Sachdev S., Troyanskaya, Olga, Hauser, Stephen L., Wilson, Michael R.
Source:	Science (pre-March 2025). 12/6/2024, Vol. 386 Issue 6726, p1109-1109. 1p. 1 Diagram.
Abstract:	The article discusses research which describes the programming of immune, tissue-sensing T cells that deliver therapies to the brain. The study demonstrated the therapeutic potential of a cell-based CNS-specific delivery system customized to cancer or neuroinflammation by first identifying a set of CNS-specific extracellular ligands and brevican proteins and screening for antibodies against CNS-specific antigens, which were used to build CNS-activated synthetic Notch receptors.
Database:	Psychology and Behavioral Sciences Collection

Description
Abstract:	The article discusses research which describes the programming of immune, tissue-sensing T cells that deliver therapies to the brain. The study demonstrated the therapeutic potential of a cell-based CNS-specific delivery system customized to cancer or neuroinflammation by first identifying a set of CNS-specific extracellular ligands and brevican proteins and screening for antibodies against CNS-specific antigens, which were used to build CNS-activated synthetic Notch receptors.
ISSN:	00368075
DOI:	10.1126/science.adl4237