Programming tissue-sensing T cells that deliver therapies to the brain.
Saved in:
| Title: | Programming tissue-sensing T cells that deliver therapies to the brain. |
|---|---|
| Authors: | Simic, Milos S., Watchmaker, Payal B., Gupta, Sasha, Yuan Wang, Sagan, Sharon A., Duecker, Jason, Shepherd, Chanelle, Diebold, David, Pineo-Cavanaugh, Psalm, Haegelin, Jeffrey, Zhu, Robert, Ben Ng, Wei Yu, Tonai, Yurie, Cardarelli, Lia, Reddy, Nishith R., Sidhu, Sachdev S., Troyanskaya, Olga, Hauser, Stephen L., Wilson, Michael R. |
| Source: | Science (pre-March 2025). 12/6/2024, Vol. 386 Issue 6726, p1109-1109. 1p. 1 Diagram. |
| Abstract: | The article discusses research which describes the programming of immune, tissue-sensing T cells that deliver therapies to the brain. The study demonstrated the therapeutic potential of a cell-based CNS-specific delivery system customized to cancer or neuroinflammation by first identifying a set of CNS-specific extracellular ligands and brevican proteins and screening for antibodies against CNS-specific antigens, which were used to build CNS-activated synthetic Notch receptors. |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
|---|---|
| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 181477509 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
| IllustrationInfo | |
| Items | – Name: Title Label: Title Group: Ti Data: Programming tissue-sensing T cells that deliver therapies to the brain. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Simic%2C+Milos+S%2E%22">Simic, Milos S.</searchLink><br /><searchLink fieldCode="AR" term="%22Watchmaker%2C+Payal+B%2E%22">Watchmaker, Payal B.</searchLink><br /><searchLink fieldCode="AR" term="%22Gupta%2C+Sasha%22">Gupta, Sasha</searchLink><br /><searchLink fieldCode="AR" term="%22Yuan+Wang%22">Yuan Wang</searchLink><br /><searchLink fieldCode="AR" term="%22Sagan%2C+Sharon+A%2E%22">Sagan, Sharon A.</searchLink><br /><searchLink fieldCode="AR" term="%22Duecker%2C+Jason%22">Duecker, Jason</searchLink><br /><searchLink fieldCode="AR" term="%22Shepherd%2C+Chanelle%22">Shepherd, Chanelle</searchLink><br /><searchLink fieldCode="AR" term="%22Diebold%2C+David%22">Diebold, David</searchLink><br /><searchLink fieldCode="AR" term="%22Pineo-Cavanaugh%2C+Psalm%22">Pineo-Cavanaugh, Psalm</searchLink><br /><searchLink fieldCode="AR" term="%22Haegelin%2C+Jeffrey%22">Haegelin, Jeffrey</searchLink><br /><searchLink fieldCode="AR" term="%22Zhu%2C+Robert%22">Zhu, Robert</searchLink><br /><searchLink fieldCode="AR" term="%22Ben+Ng%22">Ben Ng</searchLink><br /><searchLink fieldCode="AR" term="%22Wei+Yu%22">Wei Yu</searchLink><br /><searchLink fieldCode="AR" term="%22Tonai%2C+Yurie%22">Tonai, Yurie</searchLink><br /><searchLink fieldCode="AR" term="%22Cardarelli%2C+Lia%22">Cardarelli, Lia</searchLink><br /><searchLink fieldCode="AR" term="%22Reddy%2C+Nishith+R%2E%22">Reddy, Nishith R.</searchLink><br /><searchLink fieldCode="AR" term="%22Sidhu%2C+Sachdev+S%2E%22">Sidhu, Sachdev S.</searchLink><br /><searchLink fieldCode="AR" term="%22Troyanskaya%2C+Olga%22">Troyanskaya, Olga</searchLink><br /><searchLink fieldCode="AR" term="%22Hauser%2C+Stephen+L%2E%22">Hauser, Stephen L.</searchLink><br /><searchLink fieldCode="AR" term="%22Wilson%2C+Michael+R%2E%22">Wilson, Michael R.</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Science+%28pre-March+2025%29%22">Science (pre-March 2025)</searchLink>. 12/6/2024, Vol. 386 Issue 6726, p1109-1109. 1p. 1 Diagram. – Name: Abstract Label: Abstract Group: Ab Data: The article discusses research which describes the programming of immune, tissue-sensing T cells that deliver therapies to the brain. The study demonstrated the therapeutic potential of a cell-based CNS-specific delivery system customized to cancer or neuroinflammation by first identifying a set of CNS-specific extracellular ligands and brevican proteins and screening for antibodies against CNS-specific antigens, which were used to build CNS-activated synthetic Notch receptors. |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=181477509 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1126/science.adl4237 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 1 StartPage: 1109 Titles: – TitleFull: Programming tissue-sensing T cells that deliver therapies to the brain. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Simic, Milos S. – PersonEntity: Name: NameFull: Watchmaker, Payal B. – PersonEntity: Name: NameFull: Gupta, Sasha – PersonEntity: Name: NameFull: Yuan Wang – PersonEntity: Name: NameFull: Sagan, Sharon A. – PersonEntity: Name: NameFull: Duecker, Jason – PersonEntity: Name: NameFull: Shepherd, Chanelle – PersonEntity: Name: NameFull: Diebold, David – PersonEntity: Name: NameFull: Pineo-Cavanaugh, Psalm – PersonEntity: Name: NameFull: Haegelin, Jeffrey – PersonEntity: Name: NameFull: Zhu, Robert – PersonEntity: Name: NameFull: Ben Ng – PersonEntity: Name: NameFull: Wei Yu – PersonEntity: Name: NameFull: Tonai, Yurie – PersonEntity: Name: NameFull: Cardarelli, Lia – PersonEntity: Name: NameFull: Reddy, Nishith R. – PersonEntity: Name: NameFull: Sidhu, Sachdev S. – PersonEntity: Name: NameFull: Troyanskaya, Olga – PersonEntity: Name: NameFull: Hauser, Stephen L. – PersonEntity: Name: NameFull: Wilson, Michael R. IsPartOfRelationships: – BibEntity: Dates: – D: 06 M: 12 Text: 12/6/2024 Type: published Y: 2024 Identifiers: – Type: issn-print Value: 00368075 Numbering: – Type: volume Value: 386 – Type: issue Value: 6726 Titles: – TitleFull: Science (pre-March 2025) Type: main |
| ResultId | 1 |
