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Changes in choroidal thickness and blood flow in response to form deprivation‐induced myopia and repeated low‐level red‐light therapy in Guinea pigs.

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Title: Changes in choroidal thickness and blood flow in response to form deprivation‐induced myopia and repeated low‐level red‐light therapy in Guinea pigs.
Authors: Xiang, Aiqun (AUTHOR), He, Hong (AUTHOR), Li, Anzhen (AUTHOR), Meng, Xuyun (AUTHOR), Luo, Yanting (AUTHOR), Luo, Yuhan (AUTHOR), Wang, Xingxing (AUTHOR), Yang, Junming (AUTHOR), Chen, Xiaolian (AUTHOR), Zhong, Xingwu (AUTHOR)
Source: Ophthalmic & Physiological Optics. Jan2025, Vol. 45 Issue 1, p111-119. 9p.
Subjects: Choroid, Optical coherence tomography, Guinea pigs, Blood flow, Actinic flux
Abstract: Purpose: To evaluate ocular refractive development, choroidal thickness (ChT) and changes in choroidal blood flow in form‐deprived myopia (FDM) Guinea pigs treated with repeated low‐level red‐light (RLRL) therapy. Methods: Twenty‐eight 3‐week‐old male tricolour Guinea pigs were randomised into three groups: normal controls (NC, n = 10), form‐deprived (FD, n = 10) and red light treated with form‐deprivation (RLFD, n = 8). Interocular refraction and axial length (AL) changes were monitored. Optical coherence tomography angiography (OCTA) measured choroidal thickness, vessel area density, vessel skeleton density and blood flow signal intensity (flux) in the choriocapillaris and medium–large vessel layers. The experimental intervention lasted 3 weeks. Results: At week 3, the FD group had higher myopia and longer axial length than the NC group (all p < 0.001). The RLFD group had higher hyperopia and shorter axial length than the FD group (all p < 0.001). At week 1, the NC group had a thicker choroidal thickness than the FD group (p < 0.05). At weeks 2 and 3, the RLFD group had a thicker choroidal thickness than the FD group (p = 0.002, p < 0.001, respectively). Additionally, the NC group had higher vessel area density, vessel skeleton density and flux in the choriocapillaris layer than the FD group at the three follow‐up time points (all p < 0.05). At week 3, the vessel skeleton density and flux were higher in the RLFD group than in the FD group (all p < 0.05). Correlation analysis results showed that weekly changes in refraction and choroidal thickness were negatively correlated with changes in axial length (all p < 0.05). Choroidal thickness changes were positively correlated with alterations in the vessel area density, vessel skeleton density and flux in the choriocapillaris layer, as well as vessel skeleton density and flux changes in the medium–large vessel layers (all p < 0.05). Conclusions: Repeated low‐level red‐light (RLRL) therapy retards FDM progression in Guinea pigs, potentially through increased choroidal blood flow in the choriocapillaris layer. [ABSTRACT FROM AUTHOR]
Copyright of Ophthalmic & Physiological Optics is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Group: Ti
  Data: Changes in choroidal thickness and blood flow in response to form deprivation‐induced myopia and repeated low‐level red‐light therapy in Guinea pigs.
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  Data: &lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Xiang%2C+Aiqun%22&quot;&gt;Xiang, Aiqun&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22He%2C+Hong%22&quot;&gt;He, Hong&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Li%2C+Anzhen%22&quot;&gt;Li, Anzhen&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Meng%2C+Xuyun%22&quot;&gt;Meng, Xuyun&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Luo%2C+Yanting%22&quot;&gt;Luo, Yanting&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Luo%2C+Yuhan%22&quot;&gt;Luo, Yuhan&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Wang%2C+Xingxing%22&quot;&gt;Wang, Xingxing&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Yang%2C+Junming%22&quot;&gt;Yang, Junming&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Chen%2C+Xiaolian%22&quot;&gt;Chen, Xiaolian&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Zhong%2C+Xingwu%22&quot;&gt;Zhong, Xingwu&lt;/searchLink&gt; (AUTHOR)
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  Data: &lt;searchLink fieldCode=&quot;JN&quot; term=&quot;%22Ophthalmic+%26+Physiological+Optics%22&quot;&gt;Ophthalmic &amp; Physiological Optics&lt;/searchLink&gt;. Jan2025, Vol. 45 Issue 1, p111-119. 9p.
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  Data: &lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Choroid%22&quot;&gt;Choroid&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Optical+coherence+tomography%22&quot;&gt;Optical coherence tomography&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Guinea+pigs%22&quot;&gt;Guinea pigs&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Blood+flow%22&quot;&gt;Blood flow&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Actinic+flux%22&quot;&gt;Actinic flux&lt;/searchLink&gt;
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Purpose: To evaluate ocular refractive development, choroidal thickness (ChT) and changes in choroidal blood flow in form‐deprived myopia (FDM) Guinea pigs treated with repeated low‐level red‐light (RLRL) therapy. Methods: Twenty‐eight 3‐week‐old male tricolour Guinea pigs were randomised into three groups: normal controls (NC, n = 10), form‐deprived (FD, n = 10) and red light treated with form‐deprivation (RLFD, n = 8). Interocular refraction and axial length (AL) changes were monitored. Optical coherence tomography angiography (OCTA) measured choroidal thickness, vessel area density, vessel skeleton density and blood flow signal intensity (flux) in the choriocapillaris and medium–large vessel layers. The experimental intervention lasted 3 weeks. Results: At week 3, the FD group had higher myopia and longer axial length than the NC group (all p &lt; 0.001). The RLFD group had higher hyperopia and shorter axial length than the FD group (all p &lt; 0.001). At week 1, the NC group had a thicker choroidal thickness than the FD group (p &lt; 0.05). At weeks 2 and 3, the RLFD group had a thicker choroidal thickness than the FD group (p = 0.002, p &lt; 0.001, respectively). Additionally, the NC group had higher vessel area density, vessel skeleton density and flux in the choriocapillaris layer than the FD group at the three follow‐up time points (all p &lt; 0.05). At week 3, the vessel skeleton density and flux were higher in the RLFD group than in the FD group (all p &lt; 0.05). Correlation analysis results showed that weekly changes in refraction and choroidal thickness were negatively correlated with changes in axial length (all p &lt; 0.05). Choroidal thickness changes were positively correlated with alterations in the vessel area density, vessel skeleton density and flux in the choriocapillaris layer, as well as vessel skeleton density and flux changes in the medium–large vessel layers (all p &lt; 0.05). Conclusions: Repeated low‐level red‐light (RLRL) therapy retards FDM progression in Guinea pigs, potentially through increased choroidal blood flow in the choriocapillaris layer. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
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  Data: &lt;i&gt;Copyright of Ophthalmic &amp; Physiological Optics is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder&#39;s express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.&lt;/i&gt; (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
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    Identifiers:
      – Type: doi
        Value: 10.1111/opo.13404
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      – Code: eng
        Text: English
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    Subjects:
      – SubjectFull: Choroid
        Type: general
      – SubjectFull: Optical coherence tomography
        Type: general
      – SubjectFull: Guinea pigs
        Type: general
      – SubjectFull: Blood flow
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      – SubjectFull: Actinic flux
        Type: general
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      – TitleFull: Changes in choroidal thickness and blood flow in response to form deprivation‐induced myopia and repeated low‐level red‐light therapy in Guinea pigs.
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              Text: Jan2025
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              Y: 2025
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