tDCS does not add effect to foot drop stimulator and gait training in improving clinical parameters and neuroplasticity biomarkers in chronic post-stroke: randomized controlled trial.
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| Title: | tDCS does not add effect to foot drop stimulator and gait training in improving clinical parameters and neuroplasticity biomarkers in chronic post-stroke: randomized controlled trial. |
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| Authors: | da Cunha, Maira Jaqueline (AUTHOR), Pires Dorneles, Gilson (AUTHOR), Peres, Alessandra (AUTHOR), Maurer, Simone (AUTHOR), Horn, Keli (AUTHOR), Souza Pagnussat, Aline (AUTHOR) |
| Source: | International Journal of Neuroscience. Dec2024, Vol. 134 Issue 12, p1518-1527. 10p. |
| Subjects: | Transcranial direct current stimulation, Brain-derived neurotrophic factor, Neuroplasticity, Stroke rehabilitation, Body-weight-supported treadmill training, Randomized controlled trials |
| Abstract: | Background: Transcranial direct current stimulation (tDCS) and foot drop stimulators (FDS) are widely used for stroke rehabilitation. However, no study has investigated if tDCS could boost the effects of FDS and gait training in improving clinical parameters and neuroplasticity biomarkers of chronic post-stroke subjects. Objective: To investigate the effects of combining tDCS and FDS on motor impairment, functional mobility, and brain-derived neurotrophic factor (BDNF) serum levels. Also, to evaluate the effects of this protocol on the insulin-like growth factor-1 (IGF-1), insulin growth factor–binding proteins-3 (IGFBP-3), interleukin (IL) 6 and 10, and tumor necrosis factor-α (TNF-α) levels. Methods: Thirty-two chronic post-stroke individuals were randomized to tDCS plus FDS or sham tDCS plus FDS groups. Both groups underwent ten gait training sessions for two weeks using a FDS device and real or sham tDCS. Blood samples and clinical data were acquired before and after the intervention. Motor impairment was assessed by the Fugl-Meyer Assessment and functional mobility using the Timed up and Go test. Results: Both groups improved the motor impairment and functional mobility and increased the BDNF levels. Both groups also increased the IL-10 and decreased the cortisol, IL-6, and TNF-α levels. No difference was observed between groups. Conclusion: tDCS did not add effect to FDS and gait training in improving clinical parameters and neuroplasticity biomarkers in chronic post-stroke individuals. Only FDS and gait training might be enough for people with chronic stroke to modify some clinical parameters and neuroplasticity biomarkers. [ABSTRACT FROM AUTHOR] |
| Copyright of International Journal of Neuroscience is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 181550496 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: tDCS does not add effect to foot drop stimulator and gait training in improving clinical parameters and neuroplasticity biomarkers in chronic post-stroke: randomized controlled trial. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22da+Cunha%2C+Maira+Jaqueline%22">da Cunha, Maira Jaqueline</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Pires+Dorneles%2C+Gilson%22">Pires Dorneles, Gilson</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Peres%2C+Alessandra%22">Peres, Alessandra</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Maurer%2C+Simone%22">Maurer, Simone</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Horn%2C+Keli%22">Horn, Keli</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Souza+Pagnussat%2C+Aline%22">Souza Pagnussat, Aline</searchLink> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22International+Journal+of+Neuroscience%22">International Journal of Neuroscience</searchLink>. Dec2024, Vol. 134 Issue 12, p1518-1527. 10p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Transcranial+direct+current+stimulation%22">Transcranial direct current stimulation</searchLink><br /><searchLink fieldCode="DE" term="%22Brain-derived+neurotrophic+factor%22">Brain-derived neurotrophic factor</searchLink><br /><searchLink fieldCode="DE" term="%22Neuroplasticity%22">Neuroplasticity</searchLink><br /><searchLink fieldCode="DE" term="%22Stroke+rehabilitation%22">Stroke rehabilitation</searchLink><br /><searchLink fieldCode="DE" term="%22Body-weight-supported+treadmill+training%22">Body-weight-supported treadmill training</searchLink><br /><searchLink fieldCode="DE" term="%22Randomized+controlled+trials%22">Randomized controlled trials</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Background: Transcranial direct current stimulation (tDCS) and foot drop stimulators (FDS) are widely used for stroke rehabilitation. However, no study has investigated if tDCS could boost the effects of FDS and gait training in improving clinical parameters and neuroplasticity biomarkers of chronic post-stroke subjects. Objective: To investigate the effects of combining tDCS and FDS on motor impairment, functional mobility, and brain-derived neurotrophic factor (BDNF) serum levels. Also, to evaluate the effects of this protocol on the insulin-like growth factor-1 (IGF-1), insulin growth factor–binding proteins-3 (IGFBP-3), interleukin (IL) 6 and 10, and tumor necrosis factor-α (TNF-α) levels. Methods: Thirty-two chronic post-stroke individuals were randomized to tDCS plus FDS or sham tDCS plus FDS groups. Both groups underwent ten gait training sessions for two weeks using a FDS device and real or sham tDCS. Blood samples and clinical data were acquired before and after the intervention. Motor impairment was assessed by the Fugl-Meyer Assessment and functional mobility using the Timed up and Go test. Results: Both groups improved the motor impairment and functional mobility and increased the BDNF levels. Both groups also increased the IL-10 and decreased the cortisol, IL-6, and TNF-α levels. No difference was observed between groups. Conclusion: tDCS did not add effect to FDS and gait training in improving clinical parameters and neuroplasticity biomarkers in chronic post-stroke individuals. Only FDS and gait training might be enough for people with chronic stroke to modify some clinical parameters and neuroplasticity biomarkers. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of International Journal of Neuroscience is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1080/00207454.2023.2272041 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 10 StartPage: 1518 Subjects: – SubjectFull: Transcranial direct current stimulation Type: general – SubjectFull: Brain-derived neurotrophic factor Type: general – SubjectFull: Neuroplasticity Type: general – SubjectFull: Stroke rehabilitation Type: general – SubjectFull: Body-weight-supported treadmill training Type: general – SubjectFull: Randomized controlled trials Type: general Titles: – TitleFull: tDCS does not add effect to foot drop stimulator and gait training in improving clinical parameters and neuroplasticity biomarkers in chronic post-stroke: randomized controlled trial. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: da Cunha, Maira Jaqueline – PersonEntity: Name: NameFull: Pires Dorneles, Gilson – PersonEntity: Name: NameFull: Peres, Alessandra – PersonEntity: Name: NameFull: Maurer, Simone – PersonEntity: Name: NameFull: Horn, Keli – PersonEntity: Name: NameFull: Souza Pagnussat, Aline IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 12 Text: Dec2024 Type: published Y: 2024 Identifiers: – Type: issn-print Value: 00207454 Numbering: – Type: volume Value: 134 – Type: issue Value: 12 Titles: – TitleFull: International Journal of Neuroscience Type: main |
| ResultId | 1 |
