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Pharmacological targeting of dopamine D1 or D2 receptors evokes a rapid‐onset parkinsonian motor phenotype in mice.

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Title: Pharmacological targeting of dopamine D1 or D2 receptors evokes a rapid‐onset parkinsonian motor phenotype in mice.
Authors: del Agua Villa, Christian (AUTHOR), Atudorei, Mihai (AUTHOR), Siebner, Hartwig Roman (AUTHOR), Rickhag, Mattias (AUTHOR)
Source: European Journal of Neuroscience. Dec2024, Vol. 60 Issue 12, p7006-7024. 19p.
Subjects: Dopamine receptors, Parkinson's disease, Parallel electric circuits, Dopamine antagonists, Induction motors
Abstract: Dopaminergic nigrostriatal denervation in Parkinson's disease (PD) disrupts the functional balance between striatal projecting neurons, leading to aberrant activity in the cortico‐basal ganglia circuit and characteristic motor symptoms. While genetic and toxin‐based animal models are commonly used to mimic PD pathology and behaviour, they have limitations when combined with circuit manipulation tools. This highlights the need for complementary approaches, particularly when combined with viral‐based circuit targeting of specific neuronal subpopulations involved in PD circuit dysfunction. Here, we pursue a pharmacological approach targeting dopamine D1 or D2 receptors to induce dopamine deprivation and to replicate key motor symptoms in PD. We demonstrate a clear dose‐dependent induction of parkinsonian motor behaviour by both a dopamine D1 receptor antagonist (SCH23390) and a D2 receptor antagonist (haloperidol). The motor phenotype is evaluated by considering relevant motor metrics in an open‐field maze platform. The proposed parkinsonian pharmacological model constitutes an acute, flexible approach, which allows parallel brain circuit manipulations. [ABSTRACT FROM AUTHOR]
Copyright of European Journal of Neuroscience is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Label: Title
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  Data: Pharmacological targeting of dopamine D1 or D2 receptors evokes a rapid‐onset parkinsonian motor phenotype in mice.
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  Data: <searchLink fieldCode="AR" term="%22del+Agua+Villa%2C+Christian%22">del Agua Villa, Christian</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Atudorei%2C+Mihai%22">Atudorei, Mihai</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Siebner%2C+Hartwig+Roman%22">Siebner, Hartwig Roman</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Rickhag%2C+Mattias%22">Rickhag, Mattias</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22European+Journal+of+Neuroscience%22">European Journal of Neuroscience</searchLink>. Dec2024, Vol. 60 Issue 12, p7006-7024. 19p.
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  Data: <searchLink fieldCode="DE" term="%22Dopamine+receptors%22">Dopamine receptors</searchLink><br /><searchLink fieldCode="DE" term="%22Parkinson's+disease%22">Parkinson's disease</searchLink><br /><searchLink fieldCode="DE" term="%22Parallel+electric+circuits%22">Parallel electric circuits</searchLink><br /><searchLink fieldCode="DE" term="%22Dopamine+antagonists%22">Dopamine antagonists</searchLink><br /><searchLink fieldCode="DE" term="%22Induction+motors%22">Induction motors</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Dopaminergic nigrostriatal denervation in Parkinson's disease (PD) disrupts the functional balance between striatal projecting neurons, leading to aberrant activity in the cortico‐basal ganglia circuit and characteristic motor symptoms. While genetic and toxin‐based animal models are commonly used to mimic PD pathology and behaviour, they have limitations when combined with circuit manipulation tools. This highlights the need for complementary approaches, particularly when combined with viral‐based circuit targeting of specific neuronal subpopulations involved in PD circuit dysfunction. Here, we pursue a pharmacological approach targeting dopamine D1 or D2 receptors to induce dopamine deprivation and to replicate key motor symptoms in PD. We demonstrate a clear dose‐dependent induction of parkinsonian motor behaviour by both a dopamine D1 receptor antagonist (SCH23390) and a D2 receptor antagonist (haloperidol). The motor phenotype is evaluated by considering relevant motor metrics in an open‐field maze platform. The proposed parkinsonian pharmacological model constitutes an acute, flexible approach, which allows parallel brain circuit manipulations. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of European Journal of Neuroscience is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=181679133
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        Value: 10.1111/ejn.16622
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      – Code: eng
        Text: English
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        Type: general
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      – SubjectFull: Parallel electric circuits
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      – TitleFull: Pharmacological targeting of dopamine D1 or D2 receptors evokes a rapid‐onset parkinsonian motor phenotype in mice.
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              M: 12
              Text: Dec2024
              Type: published
              Y: 2024
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