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Risk of subsequent Parkinson's disease among patients with bipolar disorder or major depression: A nationwide longitudinal study in Taiwan.

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Title: Risk of subsequent Parkinson's disease among patients with bipolar disorder or major depression: A nationwide longitudinal study in Taiwan.
Authors: Huang, Mao‐Hsuan (AUTHOR), Cheng, Chih‐Ming (AUTHOR), Hsu, Ju‐Wei (AUTHOR), Bai, Ya‐Mei (AUTHOR), Su, Tung‐Ping (AUTHOR), Li, Cheng‐Ta (AUTHOR), Tsai, Shih‐Jen (AUTHOR), Chan, Yee‐Lam E (AUTHOR), Chen, Mu‐Hong (AUTHOR)
Source: Psychiatry & Clinical Neurosciences. Jan2025, Vol. 79 Issue 1, p29-36. 8p.
Subjects: Parkinson's disease, Mental depression, Bipolar disorder, Mood stabilizers, Psychiatric drugs
Abstract: Aim: Bipolar disorder (BD) and major depression have been associated with an increased risk of developing Parkinson's disease (PD); however, few studies have directly compared the risk of PD development between patients with BD and major depression while considering relevant risk factors and psychotropic medications. Methods: Using the Taiwan National Health Insurance Research Database, 21,186 patients with BD, 21,188 patients with major depression, and 42,374 controls were enrolled between 2001 and 2009, and followed until the end of 2011. Individuals who developed PD during the follow‐up period were identified. Cox regression models were used to analyze the hazard ratio (HR) of developing PD, adjusting for demographic factors, comorbidities, and psychotropic medication usage. Results: Both patients with BD [HR 8.63, 95% confidence interval (CI) 6.35–11.72] and those with major depression (HR 5.68, 95% CI 4.15–7.78) had an elevated risk of subsequent PD compared to the controls. Patients with BD were associated with a 51% increased risk of subsequent PD compared with patients with major depression. Long‐term treatment with antiepileptic mood stabilizers was associated with increased PD risk among patients with late‐onset BD and high Charlson comorbidity index scores. Lithium was not associated with an increased PD risk. Conclusions: The study highlights an elevated PD risk in patients with BD and major depression compared to the controls, with BD patients at highest risk. Further research is needed to elucidate the complex interplay between psychotropic medications and neurodegenerative processes in BD, aiming to optimize therapeutic strategies and improve patient outcomes. [ABSTRACT FROM AUTHOR]
Copyright of Psychiatry & Clinical Neurosciences is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Risk of subsequent Parkinson's disease among patients with bipolar disorder or major depression: A nationwide longitudinal study in Taiwan.
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  Data: <searchLink fieldCode="AR" term="%22Huang%2C+Mao‐Hsuan%22">Huang, Mao‐Hsuan</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Cheng%2C+Chih‐Ming%22">Cheng, Chih‐Ming</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Hsu%2C+Ju‐Wei%22">Hsu, Ju‐Wei</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Bai%2C+Ya‐Mei%22">Bai, Ya‐Mei</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Su%2C+Tung‐Ping%22">Su, Tung‐Ping</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Li%2C+Cheng‐Ta%22">Li, Cheng‐Ta</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Tsai%2C+Shih‐Jen%22">Tsai, Shih‐Jen</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Chan%2C+Yee‐Lam+E%22">Chan, Yee‐Lam E</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Chen%2C+Mu‐Hong%22">Chen, Mu‐Hong</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Psychiatry+%26+Clinical+Neurosciences%22">Psychiatry & Clinical Neurosciences</searchLink>. Jan2025, Vol. 79 Issue 1, p29-36. 8p.
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  Label: Subjects
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  Data: <searchLink fieldCode="DE" term="%22Parkinson's+disease%22">Parkinson's disease</searchLink><br /><searchLink fieldCode="DE" term="%22Mental+depression%22">Mental depression</searchLink><br /><searchLink fieldCode="DE" term="%22Bipolar+disorder%22">Bipolar disorder</searchLink><br /><searchLink fieldCode="DE" term="%22Mood+stabilizers%22">Mood stabilizers</searchLink><br /><searchLink fieldCode="DE" term="%22Psychiatric+drugs%22">Psychiatric drugs</searchLink>
– Name: Abstract
  Label: Abstract
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  Data: Aim: Bipolar disorder (BD) and major depression have been associated with an increased risk of developing Parkinson's disease (PD); however, few studies have directly compared the risk of PD development between patients with BD and major depression while considering relevant risk factors and psychotropic medications. Methods: Using the Taiwan National Health Insurance Research Database, 21,186 patients with BD, 21,188 patients with major depression, and 42,374 controls were enrolled between 2001 and 2009, and followed until the end of 2011. Individuals who developed PD during the follow‐up period were identified. Cox regression models were used to analyze the hazard ratio (HR) of developing PD, adjusting for demographic factors, comorbidities, and psychotropic medication usage. Results: Both patients with BD [HR 8.63, 95% confidence interval (CI) 6.35–11.72] and those with major depression (HR 5.68, 95% CI 4.15–7.78) had an elevated risk of subsequent PD compared to the controls. Patients with BD were associated with a 51% increased risk of subsequent PD compared with patients with major depression. Long‐term treatment with antiepileptic mood stabilizers was associated with increased PD risk among patients with late‐onset BD and high Charlson comorbidity index scores. Lithium was not associated with an increased PD risk. Conclusions: The study highlights an elevated PD risk in patients with BD and major depression compared to the controls, with BD patients at highest risk. Further research is needed to elucidate the complex interplay between psychotropic medications and neurodegenerative processes in BD, aiming to optimize therapeutic strategies and improve patient outcomes. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
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  Data: <i>Copyright of Psychiatry & Clinical Neurosciences is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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      – SubjectFull: Mental depression
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      – SubjectFull: Bipolar disorder
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      – SubjectFull: Mood stabilizers
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              Text: Jan2025
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