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Lack of association between TRPV1 gene polymorphisms and risk of migraine chronification: a case-control study and meta-analysis.

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Title: Lack of association between TRPV1 gene polymorphisms and risk of migraine chronification: a case-control study and meta-analysis.
Authors: Giacon, Martina (AUTHOR), Cargnin, Sarah (AUTHOR), Allena, Marta (AUTHOR), Greco, Rosaria (AUTHOR), Zanaboni, Anna Maria (AUTHOR), Facchetti, Sara (AUTHOR), De Icco, Roberto (AUTHOR), Sances, Grazia (AUTHOR), Ghiotto, Natascia (AUTHOR), Guaschino, Elena (AUTHOR), Martinelli, Daniele (AUTHOR), Tassorelli, Cristina (AUTHOR), Terrazzino, Salvatore (AUTHOR)
Source: Neurological Sciences. Jan2025, Vol. 46 Issue 1, p303-312. 10p.
Subjects: Single nucleotide polymorphisms, Genotype-environment interaction, Genetic models, TRPV cation channels, Genetic polymorphisms
Abstract: Objective: To confirm a previously reported association of TRPV1 rs8065080 with the risk of transformation from episodic (EM) to chronic migraine (CM) and to extend knowledge about the role of other TRPV1 single nucleotide polymorphisms (SNPs), we first investigated the impact of three TRPV1 SNPs (rs8065080, rs222747 and rs222749) on the risk of migraine chronification in a case-control study. A systematic review and meta-analysis were then conducted to summarize the accumulated findings. Methods: Genotyping of the selected TRPV1 SNPs was performed using TaqMan real-time PCR in 167 EM and 182 CM participants. Crude and adjusted odds ratios with associated 95% confidence intervals were calculated in the log-additive, dominant, and recessive genetic models. A comprehensive literature search was performed in PubMed, Web of Knowledge, Cochrane Library, and OpenGrey until February 2024. Results: In our case-control study, no association was found between TRPV1 SNPs and the risk of migraine chronification, both in the unadjusted logistic regression models and after adjustment for confounding clinical variables. The results of the meta-analysis with a total of 241 participants with EM and 223 with CM confirmed no association between TRPV1 SNPs and the risk of migraine chronification in any of the genetic models tested. Conclusion: The results of the present case-control study and meta-analysis exclude a major role of TRPV1 rs8065080, rs222747, and rs222749 as risk factors for migraine chronification. However, further research is needed to investigate the gene-gene and gene-environment interactions of TRPV1 SNPs on the risk of transformation from episodic to chronic migraine. [ABSTRACT FROM AUTHOR]
Copyright of Neurological Sciences is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Lack of association between TRPV1 gene polymorphisms and risk of migraine chronification: a case-control study and meta-analysis.
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  Data: <searchLink fieldCode="AR" term="%22Giacon%2C+Martina%22">Giacon, Martina</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Cargnin%2C+Sarah%22">Cargnin, Sarah</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Allena%2C+Marta%22">Allena, Marta</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Greco%2C+Rosaria%22">Greco, Rosaria</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zanaboni%2C+Anna+Maria%22">Zanaboni, Anna Maria</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Facchetti%2C+Sara%22">Facchetti, Sara</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22De+Icco%2C+Roberto%22">De Icco, Roberto</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Sances%2C+Grazia%22">Sances, Grazia</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ghiotto%2C+Natascia%22">Ghiotto, Natascia</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Guaschino%2C+Elena%22">Guaschino, Elena</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Martinelli%2C+Daniele%22">Martinelli, Daniele</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Tassorelli%2C+Cristina%22">Tassorelli, Cristina</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Terrazzino%2C+Salvatore%22">Terrazzino, Salvatore</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Neurological+Sciences%22">Neurological Sciences</searchLink>. Jan2025, Vol. 46 Issue 1, p303-312. 10p.
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  Data: <searchLink fieldCode="DE" term="%22Single+nucleotide+polymorphisms%22">Single nucleotide polymorphisms</searchLink><br /><searchLink fieldCode="DE" term="%22Genotype-environment+interaction%22">Genotype-environment interaction</searchLink><br /><searchLink fieldCode="DE" term="%22Genetic+models%22">Genetic models</searchLink><br /><searchLink fieldCode="DE" term="%22TRPV+cation+channels%22">TRPV cation channels</searchLink><br /><searchLink fieldCode="DE" term="%22Genetic+polymorphisms%22">Genetic polymorphisms</searchLink>
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  Data: Objective: To confirm a previously reported association of TRPV1 rs8065080 with the risk of transformation from episodic (EM) to chronic migraine (CM) and to extend knowledge about the role of other TRPV1 single nucleotide polymorphisms (SNPs), we first investigated the impact of three TRPV1 SNPs (rs8065080, rs222747 and rs222749) on the risk of migraine chronification in a case-control study. A systematic review and meta-analysis were then conducted to summarize the accumulated findings. Methods: Genotyping of the selected TRPV1 SNPs was performed using TaqMan real-time PCR in 167 EM and 182 CM participants. Crude and adjusted odds ratios with associated 95% confidence intervals were calculated in the log-additive, dominant, and recessive genetic models. A comprehensive literature search was performed in PubMed, Web of Knowledge, Cochrane Library, and OpenGrey until February 2024. Results: In our case-control study, no association was found between TRPV1 SNPs and the risk of migraine chronification, both in the unadjusted logistic regression models and after adjustment for confounding clinical variables. The results of the meta-analysis with a total of 241 participants with EM and 223 with CM confirmed no association between TRPV1 SNPs and the risk of migraine chronification in any of the genetic models tested. Conclusion: The results of the present case-control study and meta-analysis exclude a major role of TRPV1 rs8065080, rs222747, and rs222749 as risk factors for migraine chronification. However, further research is needed to investigate the gene-gene and gene-environment interactions of TRPV1 SNPs on the risk of transformation from episodic to chronic migraine. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Neurological Sciences is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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