Endoplasmic reticulum's role in multiple sclerosis, exploring potential biomarkers, and pioneering therapeutic strategies: a comprehensive review of literature.
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| Title: | Endoplasmic reticulum's role in multiple sclerosis, exploring potential biomarkers, and pioneering therapeutic strategies: a comprehensive review of literature. |
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| Authors: | Noori, Hamid (AUTHOR), Alazzeh, Zainab Jamal (AUTHOR), Rehman, Obaid Ur (AUTHOR), Idrees, Muhammad (AUTHOR), Marsool, Mohammad Dheyaa Marsool (AUTHOR), Abdul Rehman, Khawaja (AUTHOR), Gohil, Krutika Mahendra (AUTHOR), Ahmad, Sundus Shafat (AUTHOR), Subash, Tushar (AUTHOR), Dixon, Kayla (AUTHOR) |
| Source: | Neurological Sciences. Jan2025, Vol. 46 Issue 1, p113-123. 11p. |
| Subjects: | Unfolded protein response, Medical sciences, Endoplasmic reticulum, Central nervous system, Multiple sclerosis |
| Abstract: | Background: Multiple Sclerosis (MS) is a complex and chronic autoimmune disease that affects the central nervous system. Inflammation and demyelination characterize it, which results in a range of neurological impairments. The increasing worldwide occurrence of MS, affecting an estimated 2.8 million individuals in 2020, highlights the urgent requirement for further research to tackle the significant impact it has on individuals and healthcare systems globally. Objective: In this study, we wanted to explore the complex function of the endoplasmic reticulum (ER) in the origin, development, and resolution of MS, emphasizing its importance in neuroinflammatory illnesses. The ER has become a central focus in comprehending the pathogenesis of MS. Upon reviewing the literature, we observed a lack of thorough analysis that explores the involvement of endoplasmic reticulum stress in multiple sclerosis. Thus, we aimed through this research to examine the correlations between ER stress and its influence on immunological dysregulation, demyelination, and neurodegeneration in MS. Findings: Based on the latest clinical trials, we suggested theories that explore possible biomarkers linked to ER stress and the unfolded protein response. Identifying molecules that are suggestive of early stages of illness and can serve as prognostic tools for improving our understanding of the heterogeneity of MS and offering novel approaches for managing the disease. Finally, through our comprehensive search, we wanted to offer a plan for future research, suggesting new and creative methods for managing MS and encouraging the creation of specific treatments that aim to reduce the impact of MS on individuals worldwide. [ABSTRACT FROM AUTHOR] |
| Copyright of Neurological Sciences is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 182076715 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1007/s10072-024-07766-4 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 11 StartPage: 113 Subjects: – SubjectFull: Unfolded protein response Type: general – SubjectFull: Medical sciences Type: general – SubjectFull: Endoplasmic reticulum Type: general – SubjectFull: Central nervous system Type: general – SubjectFull: Multiple sclerosis Type: general Titles: – TitleFull: Endoplasmic reticulum's role in multiple sclerosis, exploring potential biomarkers, and pioneering therapeutic strategies: a comprehensive review of literature. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Noori, Hamid – PersonEntity: Name: NameFull: Alazzeh, Zainab Jamal – PersonEntity: Name: NameFull: Rehman, Obaid Ur – PersonEntity: Name: NameFull: Idrees, Muhammad – PersonEntity: Name: NameFull: Marsool, Mohammad Dheyaa Marsool – PersonEntity: Name: NameFull: Abdul Rehman, Khawaja – PersonEntity: Name: NameFull: Gohil, Krutika Mahendra – PersonEntity: Name: NameFull: Ahmad, Sundus Shafat – PersonEntity: Name: NameFull: Subash, Tushar – PersonEntity: Name: NameFull: Dixon, Kayla IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 01 Text: Jan2025 Type: published Y: 2025 Identifiers: – Type: issn-print Value: 15901874 Numbering: – Type: volume Value: 46 – Type: issue Value: 1 Titles: – TitleFull: Neurological Sciences Type: main |
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