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Muscle-derived myostatin is a major endocrine driver of follicle-stimulating hormone synthesis.

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Title: Muscle-derived myostatin is a major endocrine driver of follicle-stimulating hormone synthesis.
Authors: Ongaro, Luisina, Xiang Zhou, Ying Wang, Schultz, Hailey, Ziyue Zhou, Buddle, Evan R. S., Brûlé, Emilie, Yeu-Farn Lin, Schang, Gauthier, Hagg, Adam, Castonguay, Roselyne, Yewei Liu, Su, Gloria H., Seidah, Nabil G., Ray, Kevin C., Karp, Seth J., Boehm, Ulrich, Ruf-Zamojski, Frederique, Sealfon, Stuart C., Walton, Kelly L.
Source: Science (pre-March 2025). 1/17/2025, Vol. 387 Issue 6731, p329-336. 8p. 5 Color Photographs.
Subjects: Hormone synthesis, Myostatin, Muscle mass, Follicle-stimulating hormone, Skeletal muscle, Pituitary gland
Abstract: Myostatin is a paracrine myokine that regulates muscle mass in a variety of species, including humans. In this work, we report a functional role for myostatin as an endocrine hormone that directly promotes pituitary follicle-stimulating hormone (FSH) synthesis and thereby ovarian function in mice. Previously, this FSH-stimulating role was attributed to other members of the transforming growth factor–β family, the activins. Our results both challenge activin’s eponymous role in FSH synthesis and establish an unexpected endocrine axis between skeletal muscle and the pituitary gland. Our data also suggest that efforts to antagonize myostatin to increase muscle mass may have unintended consequences on fertility. [ABSTRACT FROM AUTHOR]
Copyright of Science (pre-March 2025) is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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DbLabel: Psychology and Behavioral Sciences Collection
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PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
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  Data: Muscle-derived myostatin is a major endocrine driver of follicle-stimulating hormone synthesis.
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  Data: <searchLink fieldCode="AR" term="%22Ongaro%2C+Luisina%22">Ongaro, Luisina</searchLink><br /><searchLink fieldCode="AR" term="%22Xiang+Zhou%22">Xiang Zhou</searchLink><br /><searchLink fieldCode="AR" term="%22Ying+Wang%22">Ying Wang</searchLink><br /><searchLink fieldCode="AR" term="%22Schultz%2C+Hailey%22">Schultz, Hailey</searchLink><br /><searchLink fieldCode="AR" term="%22Ziyue+Zhou%22">Ziyue Zhou</searchLink><br /><searchLink fieldCode="AR" term="%22Buddle%2C+Evan+R%2E+S%2E%22">Buddle, Evan R. S.</searchLink><br /><searchLink fieldCode="AR" term="%22Brûlé%2C+Emilie%22">Brûlé, Emilie</searchLink><br /><searchLink fieldCode="AR" term="%22Yeu-Farn+Lin%22">Yeu-Farn Lin</searchLink><br /><searchLink fieldCode="AR" term="%22Schang%2C+Gauthier%22">Schang, Gauthier</searchLink><br /><searchLink fieldCode="AR" term="%22Hagg%2C+Adam%22">Hagg, Adam</searchLink><br /><searchLink fieldCode="AR" term="%22Castonguay%2C+Roselyne%22">Castonguay, Roselyne</searchLink><br /><searchLink fieldCode="AR" term="%22Yewei+Liu%22">Yewei Liu</searchLink><br /><searchLink fieldCode="AR" term="%22Su%2C+Gloria+H%2E%22">Su, Gloria H.</searchLink><br /><searchLink fieldCode="AR" term="%22Seidah%2C+Nabil+G%2E%22">Seidah, Nabil G.</searchLink><br /><searchLink fieldCode="AR" term="%22Ray%2C+Kevin+C%2E%22">Ray, Kevin C.</searchLink><br /><searchLink fieldCode="AR" term="%22Karp%2C+Seth+J%2E%22">Karp, Seth J.</searchLink><br /><searchLink fieldCode="AR" term="%22Boehm%2C+Ulrich%22">Boehm, Ulrich</searchLink><br /><searchLink fieldCode="AR" term="%22Ruf-Zamojski%2C+Frederique%22">Ruf-Zamojski, Frederique</searchLink><br /><searchLink fieldCode="AR" term="%22Sealfon%2C+Stuart+C%2E%22">Sealfon, Stuart C.</searchLink><br /><searchLink fieldCode="AR" term="%22Walton%2C+Kelly+L%2E%22">Walton, Kelly L.</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22Science+%28pre-March+2025%29%22">Science (pre-March 2025)</searchLink>. 1/17/2025, Vol. 387 Issue 6731, p329-336. 8p. 5 Color Photographs.
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  Data: <searchLink fieldCode="DE" term="%22Hormone+synthesis%22">Hormone synthesis</searchLink><br /><searchLink fieldCode="DE" term="%22Myostatin%22">Myostatin</searchLink><br /><searchLink fieldCode="DE" term="%22Muscle+mass%22">Muscle mass</searchLink><br /><searchLink fieldCode="DE" term="%22Follicle-stimulating+hormone%22">Follicle-stimulating hormone</searchLink><br /><searchLink fieldCode="DE" term="%22Skeletal+muscle%22">Skeletal muscle</searchLink><br /><searchLink fieldCode="DE" term="%22Pituitary+gland%22">Pituitary gland</searchLink>
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  Label: Abstract
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  Data: Myostatin is a paracrine myokine that regulates muscle mass in a variety of species, including humans. In this work, we report a functional role for myostatin as an endocrine hormone that directly promotes pituitary follicle-stimulating hormone (FSH) synthesis and thereby ovarian function in mice. Previously, this FSH-stimulating role was attributed to other members of the transforming growth factor–β family, the activins. Our results both challenge activin’s eponymous role in FSH synthesis and establish an unexpected endocrine axis between skeletal muscle and the pituitary gland. Our data also suggest that efforts to antagonize myostatin to increase muscle mass may have unintended consequences on fertility. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Science (pre-March 2025) is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=182261634
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        Value: 10.1126/science.adi4736
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      – Code: eng
        Text: English
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        PageCount: 8
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        Type: general
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      – SubjectFull: Muscle mass
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