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Practical considerations in the establishment of psychedelic research programs.

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Title: Practical considerations in the establishment of psychedelic research programs.
Authors: Barnett, Brian S. (AUTHOR), Vest, M. Frances (AUTHOR), Delatte, Marcus S. (AUTHOR), King IV, Franklin (AUTHOR), Mauney, Erin E. (AUTHOR), Coulson, Anthony J. (AUTHOR), Nayak, Sandeep M. (AUTHOR), Hendricks, Peter S. (AUTHOR), Greer, George R. (AUTHOR), Murnane, Kevin S. (AUTHOR)
Source: Psychopharmacology. Jan2025, Vol. 242 Issue 1, p27-43. 17p.
Subjects: Investigational drugs, Drug approval, Academic medical centers, Drug storage, Drug registration
Abstract: Rationale: There is increasing interest in establishing psychedelic research programs at academic medical centers. However, psychedelics are intensely psychoactive, carry considerable sociopolitical baggage, and most are Schedule I drugs, creating significant potential impediments to implementation. There is little formal guidance for investigators on navigating the complex on-the-ground obstacles associated with establishing psychedelic research programs. Objectives: This article provides recommendations that may be helpful to investigators seeking to work with psychedelics, with a focus on academic medical centers in the United States. Methods: The academic literature on relevant matters is reviewed, and the authors provide observations from their experiences either working for relevant regulatory agencies or conducting basic science studies, investigator-initiated trials, or industry sponsored trials with psychedelics. Results: Investigators planning to conduct psychedelic research should cultivate broad institutional support early. Challenges related to securing funding, obtaining approval for an Investigational New Drug application from the Food and Drug Administration, clinical grade drug sourcing, obtaining a Schedule I researcher registration from the Drug Enforcement Administration and an equivalent state license (if required), preparing spaces for treatment and study drug storage, managing controlled substance inventory, engaging the local community, and other issues should be anticipated. Conclusions: Investigators should anticipate several implementation challenges when planning to work with psychedelics. However, these are likely surmountable with planning, persistence, and assistance from colleagues and other experts. [ABSTRACT FROM AUTHOR]
Copyright of Psychopharmacology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: <searchLink fieldCode="AR" term="%22Barnett%2C+Brian+S%2E%22">Barnett, Brian S.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Vest%2C+M%2E+Frances%22">Vest, M. Frances</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Delatte%2C+Marcus+S%2E%22">Delatte, Marcus S.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22King IV%2C+Franklin%22">King IV, Franklin</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Mauney%2C+Erin+E%2E%22">Mauney, Erin E.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Coulson%2C+Anthony+J%2E%22">Coulson, Anthony J.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Nayak%2C+Sandeep+M%2E%22">Nayak, Sandeep M.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Hendricks%2C+Peter+S%2E%22">Hendricks, Peter S.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Greer%2C+George+R%2E%22">Greer, George R.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Murnane%2C+Kevin+S%2E%22">Murnane, Kevin S.</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Psychopharmacology%22">Psychopharmacology</searchLink>. Jan2025, Vol. 242 Issue 1, p27-43. 17p.
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  Data: Rationale: There is increasing interest in establishing psychedelic research programs at academic medical centers. However, psychedelics are intensely psychoactive, carry considerable sociopolitical baggage, and most are Schedule I drugs, creating significant potential impediments to implementation. There is little formal guidance for investigators on navigating the complex on-the-ground obstacles associated with establishing psychedelic research programs. Objectives: This article provides recommendations that may be helpful to investigators seeking to work with psychedelics, with a focus on academic medical centers in the United States. Methods: The academic literature on relevant matters is reviewed, and the authors provide observations from their experiences either working for relevant regulatory agencies or conducting basic science studies, investigator-initiated trials, or industry sponsored trials with psychedelics. Results: Investigators planning to conduct psychedelic research should cultivate broad institutional support early. Challenges related to securing funding, obtaining approval for an Investigational New Drug application from the Food and Drug Administration, clinical grade drug sourcing, obtaining a Schedule I researcher registration from the Drug Enforcement Administration and an equivalent state license (if required), preparing spaces for treatment and study drug storage, managing controlled substance inventory, engaging the local community, and other issues should be anticipated. Conclusions: Investigators should anticipate several implementation challenges when planning to work with psychedelics. However, these are likely surmountable with planning, persistence, and assistance from colleagues and other experts. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Psychopharmacology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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